<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08646

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMVVNAPESPIQAEIIFVIEATSANSAYITELRTNYIVPTLEYIGGNAENRGCITEALSTALSCFDELGRTDLPMHILLLCCSPPYSAYAGGLVPQGAPATIEQAARLISERGAHLSIASAKRLPALLALYEHAGGELHQAQQRNYAKLSSATPSSVFLDCWYRRVSLTTLLLDLLRHSAPATIEQAARLISERGAHLSIASAKRLPALLALYEHAGGELHQAQQRNYAKDPRHLVLMRGYSLKERPPSPAPPPAPDVQPDIYGPARAMGAAPRAPAAGQFQRDIRAPVRPGWMGVHPQRQPIYANNSALLTQLAQPSYPPPPAAHAQGNMQRMPSLLNQGAGPSASGVAPPLKRTYIWSGILEWMEKGKTSGDQQKVTKHLPCQVSANSKDVEPELKVETWPSKLLMQLMPKQVISNIGGQYLRDSKSVLFHLQPNEVVEALTKVMVNGYAGCVHFSPMSSPPQCDIKVLILLYTPDKKAYLGFIPNNQATFVERLRKVGKSLLHTVQFGGMPSSSMGPSNIGAALSNALNSSVGVVGQMAGPTGPGMVQPQMQPHNQQTMMIANNMGGQVGNVPGVGVGGKGPRPVTQLDGLEAARQQNLEKIQHLQQTLEAAHQQEAQFKSQMDIMTHLHAAQQQEQQYKQLEPQYRPAGGAVRPTVQTQQFDDVNNYNDFLQP
Length676
PositionUnknown
OrganismPapilio machaon (Old World swallowtail butterfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Papilionidae> Papilioninae> Papilio.
Aromaticity0.06
Grand average of hydropathy-0.303
Instability index49.67
Isoelectric point8.90
Molecular weight73323.05
Publications
PubMed=26354079

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08646
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     302.49|      63|      80|      92|     158|       1
---------------------------------------------------------------------------
   92-  147 (101.81/48.69)	......................LVPQGAPATIEQAARLISERGAHLSIASAKRLPA.......LLALYEHAGGELHQAQQRNYAK
  152-  229 (109.26/57.34)	TPSSVFLdcwyrrvslttllldLLRHSAPATIEQAARLISERGAHLSIASAKRLPA.......LLALYEHAGGELHQAQQRNYAK
  230-  305 (91.41/40.71)	DPRHLVL.....mrgyslkerpPSPAPPPAPDVQP....DIYGPARAMGAAPRAPAagqfqrdIRAPVRPGWMGVHPQRQPIYAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.80|      14|      17|     611|     626|       2
---------------------------------------------------------------------------
  611-  625 (22.93/12.66)	LEAAHQQEAQFKsQM
  631-  644 (26.87/11.63)	LHAAQQQEQQYK.QL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.62|      14|      26|     309|     322|       3
---------------------------------------------------------------------------
  309-  322 (29.20/15.05)	LLTQLAQPSYP..PPP
  336-  351 (22.42/ 9.68)	LLNQGAGPSASgvAPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.48|      26|      26|     522|     547|       4
---------------------------------------------------------------------------
  522-  547 (43.18/22.91)	IGAALSNALNSSVGVVGQMAGPTG..PG
  549-  576 (44.30/23.69)	VQPQMQPHNQQTMMIANNMGGQVGnvPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.73|      13|      21|     403|     415|       5
---------------------------------------------------------------------------
  403-  415 (23.01/15.17)	SK.LLMQLMPKQVI
  426-  439 (18.72/10.94)	SKsVLFHLQPNEVV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08646 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GNVPGVGVGGKGPRPVTQLDGLEAARQQNLEKIQHLQQTLEAAHQQEAQFKSQMDIMTHLHAAQQQEQQYKQLEPQYRPAGGAVRPTVQTQQFDDVNNYNDFLQP
2) RGYSLKERPPSPAPPPAPDVQPDIYGPARAMGAAPRAPAAGQFQRD
3) YANNSALLTQLAQPSYPPPPAAHAQGNMQRMPSLLNQGAGPSA
572
238
303
676
283
345










Molecular Recognition Features






MoRF SequenceStartStop




NANANA