<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08638

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMVVINAPETPIQAEIIFVIEATSANSAYITELRTNYIVPTLEYFHGGALEEGAGCGSVYGIVAYKAADCHPGLPIATYGPFTCPKSVVETVDKIQYIGGNAENRGCITEAFSTALSCFDELGRTDLPMHILLICCSPPYSAYAGGLVPQGAPATVEQAARLISERGAHLSIASAKRLPALMALYEHAGGELHQAQQRNYAKDPRHLVLTRGYSLKERPPSPAPKPAPDVQPDMYGQARATAAPPRGPAAPQFQRDIRAPVRPGWMGVHPQRQPIYANNSALLTQLAQPSYPPPPPAHAAQGNMQRMPSLLNQGAGPSAPGGPPTLKRTYIWSGILEWMEKGKTSGDQQKVTKHLPCQVSANSKDVEPELKVETWPNKLLMQLMPKQLISNIGGQYLRDSKSVLFHLQPNESVESLTKVMVNGYAGCVHFSPMSSPPQCDIKVLILLYTPDKKAYLGFIPNNQATFVERLRKVIQQQKITQIIKQGPAAAAGALPSATIAGSGGMPSPSMGPSNIGAALSSALNASVGVVGQMSGPTGPGMVQPQMQPHTQQTMMISNNMGGQVGNVPGVGVGGKGPRPVTQLDGLEAARQQNLEKIQHLQQTLEAAHQQEAQFKSQMDIMSHLHAAQQQEQHYKQLEPQYRPAGGAVRPTTQPQQFDEVNNYNDFL
Length666
PositionUnknown
OrganismPapilio xuthus (Asian swallowtail butterfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Papilionidae> Papilioninae> Papilio.
Aromaticity0.06
Grand average of hydropathy-0.333
Instability index48.07
Isoelectric point8.51
Molecular weight71650.02
Publications
PubMed=26354079

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08638
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.34|      22|      22|     212|     233|       1
---------------------------------------------------------------------------
  207-  228 (38.48/14.06)	VLTRGYSLKER...PP.SPAPKPAPD
  229-  251 (27.14/ 7.87)	VQPDMYGQARAtaaPPrGPA...APQ
  286-  302 (30.72/ 9.82)	AQP...SYP.....PP.PPAHAAQGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     126.06|      26|      26|     486|     511|       2
---------------------------------------------------------------------------
  306-  322 (25.99/ 9.40)	.......MPSLLNQGAG.....PSAPGGP
  486-  511 (49.40/24.99)	PAAAAGALPSATIAGSG..G.MPSPSMGP
  515-  538 (21.58/ 6.46)	....GAALSSALNASVGvvGqMSGPT.GP
  559-  578 (29.09/11.46)	MGGQVGNVPGVGVGGKG.....PRP....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.79|      39|      49|     341|     388|       3
---------------------------------------------------------------------------
  323-  362 (66.87/55.07)	PTLKrTYIWSG..ILEWME...KGKTSG....DQQKVTKHLPCQVSANS
  367-  414 (53.92/48.85)	PELK.VETWPNklLMQLMPkqlISNIGGqylrDSKSVLFHLQPNESVES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.21|      14|      17|     603|     618|       4
---------------------------------------------------------------------------
  603-  617 (22.35/12.90)	LEAAHQQEAQFKsQM
  623-  636 (26.85/12.31)	LHAAQQQEQHYK.QL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.29|      16|      50|      38|      55|       5
---------------------------------------------------------------------------
   38-   55 (27.29/21.88)	VPTLEYFHGGAleEGAGC
   91-  106 (31.01/18.43)	VDKIQYIGGNA..ENRGC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08638 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HLVLTRGYSLKERPPSPAPKPAPDVQPDMYGQARATAAPPRGPAAPQFQRDIRAPVRPGWMGVHPQRQP
2) MSGPTGPGMVQPQMQPHTQQTMMISNNMGGQVGNVPGVGVGGKGPRPVTQLDGLEAARQQNLEKIQHLQQTLEAAHQQEAQFKSQMDIMSHLHAAQQQEQHYKQLEPQYRPAGGAVRPTTQPQQFDEVNNYN
3) YANNSALLTQLAQPSYPPPPPAHAAQGNMQRMPSLLNQGAGPSAPGGPP
205
532
275
273
663
323










Molecular Recognition Features






MoRF SequenceStartStop




NANANA