<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08631

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDNLKQFNTMGSEDNWRTSNFRQNVVSKIEDVIQRSGMQVARNSSEMENHVYMKAKTREEYMNMVAKLILHVREMSQPKQNQAGGAMQGSNQNQPGPNPQVQSQQGQAPQGPNSQPGLAPDPINALQNLASQGTRNQMMNMGQGQMQQQGVMGPNPGMAGLQAQIGQQGPIVSQGGPQSQAATNLLQTLTQRPQLNMQQMQNKLNMGMVPNQNQMGNNMVSMGGMGNPMGSQLQNQLAGPGMQGQMMPNMSMSNNMQVPMSGASTMVGQMQCNQVVGGMGGQMAPNAMQGQMSRQMVGGMTNNQMVNVNMLHMQGRVGAKGEVVGGMMGAAYAPANAPPHNQFLRQSPSPSASSPNMGGPSPVPMGTSVLGGALASPMSSLGAMGACNGVGSPSPSAPAHLPHHPTQQQRGVGVGVGMGMAASPSPSSSLNTPAGVGGGGVASPGGEEAVYREKVRQLSKYIEPLRRMVQRMVNEGENVEKLTKMKNLLDILSNPNKRMPLETLIKCEVVLEKLDFKRSETVCVILPPAGTGKHEQIFNPLLEVINNCLLSPVSNHTLKRTFGHTLDALNGPEIKNLPPPHKMPKVEEPTMEIPDVLQGEIARLDSRFKVSLETMQLSGGSGAIALVAQLDDVRLPCVPAVHVAVPRDYPAHAPSRLRPRAPRPDAHRAFLAQVDRNMDARCARLPKSCSVGQLLDAWEMSVRQACAPSPVAYTPVPALGL
Length721
PositionTail
OrganismPapilio xuthus (Asian swallowtail butterfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Papilionidae> Papilioninae> Papilio.
Aromaticity0.02
Grand average of hydropathy-0.430
Instability index56.53
Isoelectric point9.35
Molecular weight76926.63
Publications
PubMed=26354079

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP08631
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.09|      21|      21|      78|      98|       1
---------------------------------------------------------------------------
   78-   96 (32.47/ 9.11)	..PK.QNQAGGAMQGSNQNQPG
   97-  117 (34.16/10.04)	PNPQvQSQQGQAPQGPN.SQPG
  208-  226 (29.46/ 7.46)	MVPN.QNQMGNNM..VSMGGMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     248.31|      44|      45|     236|     279|       2
---------------------------------------------------------------------------
  133-  165 (33.29/ 8.69)	GTRNQMM.NM..GQG.............................QMQQQGV.MGpnpGM........................aglqaQI...
  166-  240 (32.81/ 8.44)	GQQG...PIV..SQGG......PQSQAATNLlqtltqrpqlnmQQMQ.NKL......NMgmvpnqnqmgnnmvsmggmgnpmgsqlqnQLAGP
  241-  286 (89.19/36.40)	GMQGQMMPNM..SMSNN..MQVPMSGASTMV............GQMQCNQV.VG...GM...........................ggQMAPN
  287-  339 (54.07/18.98)	AMQGQMSRQMvgGMTNNqmVNVNMLHMQGRV............GAK..GEV.VG...GM......................mgaayapANAPP
  393-  423 (38.95/11.49)	.......PSP..SA......PAHLPHHPT...............Q.QQRGVgVG..vGM.............................GMAAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.66|      23|      24|     582|     605|       3
---------------------------------------------------------------------------
  582-  605 (36.99/24.17)	KMPKVEEPTMEIPDVlQGEIA...RLD
  606-  631 (33.67/17.50)	SRFKVSLETMQLSGG.SGAIAlvaQLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.02|      20|      24|     520|     543|       4
---------------------------------------------------------------------------
  523-  543 (32.37/26.87)	CvILPPAGTGKHEQIFNPLLE
  548-  567 (35.65/16.92)	C.LLSPVSNHTLKRTFGHTLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.30|      18|      75|     348|     366|       5
---------------------------------------------------------------------------
  348-  366 (34.70/14.84)	PSPSaSSPN.....MGGPSPVPMG
  424-  446 (28.60/ 8.55)	PSPS.SSLNtpagvGGGGVASPGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.02|      30|      30|     453|     482|       6
---------------------------------------------------------------------------
  453-  482 (49.29/36.51)	EKVRQLSKYI.EPLRRM.VQRMVNEGENVEKL
  483-  514 (39.73/27.89)	TKMKNLLDILsNPNKRMpLETLIKCEVVLEKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.15|      18|      23|     642|     663|       7
---------------------------------------------------------------------------
  642-  663 (28.85/26.02)	HvavpRDYPAHAPSRLR...PRAPR
  667-  687 (26.30/13.81)	H....RAFLAQVDRNMDarcARLPK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08631 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAMGACNGVGSPSPSAPAHLPHHPTQQQRGVGVGVGMGMAASPSPSSSLNTPAGVGGGGVASPGGEEA
2) MDNLKQFNTMGSEDNWRTSNFRQNVVSKIEDVIQRSGMQVARNSSEMENHVYMKAKT
3) PANAPPHNQFLRQSPSPSASSPNMGGPSPVPMGTSVLGG
4) VAKLILHVREMSQPKQNQAGGAMQGSNQNQPGPNPQVQSQQGQAPQGPNSQPGLAPDPINALQNLASQGTRNQMMNMGQGQMQQQGVMGPNPGMAGLQAQIGQQGPIVSQGGPQSQAATNLLQTLTQRPQLNMQQMQNKLNMGMVPNQNQMGNNMVSMGGMGNPMGSQLQNQLAGPGMQGQMMPNMSMSNNMQVPMSGAS
382
1
334
65
449
57
372
264










Molecular Recognition Features






MoRF SequenceStartStop




NANANA