<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08628

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMELIYSMRRKPLKCEPPHYENNADPELVKPICTISTCNIIAFSSLTELSDTDGDTWGGHVYICDLDTPWECHKVASTVHPVSALEWDGEGKQLLIATIVGEVSIYVQKDYLLNEWSCLYSAYFPGENIIKAVFFHNGRKVVAVEKKPDVPISDRIQMLRYVPTLKGFGGVACEGACIITGTGLVDALTPNGDSNRALVASDCLRSPRDHIATASFAHKNGSILIAAAWRGGGKRGVRCAACAVFRPPGSRAAPVQLTLQPLPTVYLLDHEPVSITWCLREDTDSLLIAGSTLTLWKLAERSYPVHKLLSKGPVQGNTTPGGGPKAPTECFNTVVWQQTAVWQVEGGGGGATHVGSVRLPLATPHVCSRAIGSGLAADIGAATPPKKTKYGGLPGAGGRGGGGGGATVSCVEVSQLGAVCVAVDTHSQLHVFKLSQPAPDIPTTLSVQHTTMLLEYAMVSGYDSLDVMMTLKPNIVEAVYERLTESFQRQPQPFQQYYYHNWLKLRIALCSRVAGLTSSAASLCSLQLVLAGWSAAAASLRPDEKTEAALVSFAALSNMPDEHEEKNLLALEAKAESLGEGATSAGSAWGALSAMQPLYRPLQRALDTALTMLAALTAAHNSPATPATHHHAHGYEMWSDAVALNALRRMVVIARACARGGDALSRPLARLAAIVGSAPKPDLLEECASLTVQMPARVWDALPRCNVSAPHGKPWPLHLEYDIEPEALRFVPEPPAHAQCDGTPSLAMDSIRPHLCNVKPGTCISVVDDARHVGDDAGVVGRAPSPPPCPPHCLHGTPSNVPTTEDMLPLAGIPTNSEEIFKESGDFVLESREGKFQHLQKKIVHSNIKMLITFAVMAIQ
Length859
PositionTail
OrganismPapilio xuthus (Asian swallowtail butterfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Papilionidae> Papilioninae> Papilio.
Aromaticity0.06
Grand average of hydropathy-0.037
Instability index42.72
Isoelectric point6.32
Molecular weight91864.26
Publications
PubMed=26354079

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08628
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     212.44|      52|      53|     693|     744|       1
---------------------------------------------------------------------------
  666-  701 (45.77/21.40)	PL.ARLAAIVG.............SA......P.KPDLLEEC......asltvqMPARVWDAL
  702-  750 (86.70/47.58)	PR.CNVSAPHGKPWPLHLEYDIEPEA..LRFVP.EPPAHAQC.DGTPS....laM.....DSI
  752-  807 (79.97/43.27)	PHlCNVK.PGTCISVVDDARHVGDDAgvVGRAPsPPPCPPHClHGTPS......NVPTTEDML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.51|      21|      53|     345|     366|       2
---------------------------------------------------------------------------
  345-  366 (36.42/28.70)	GGGGGATHVGSVRLPlATPHVC
  400-  419 (35.11/22.31)	GGGGGAT.VSCVEVS.QLGAVC
  422-  440 (24.98/13.38)	VDTHSQLHVFKLSQP..APDI.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     437.75|     127|     351|     127|     258|       3
---------------------------------------------------------------------------
   32-   92 (55.04/24.95)	......................................................CTiSTCnIIAF.SSLTELSDTDGDTWGGHVYI.CdLDT.PWECHKVASTV.HP....VSALEWDGEGKQ........................
  127-  258 (203.20/132.40)	NIIKAVFfhnGRKVVAVEKKPDvPISD.........RIQMLRYVPTLKGFGGVACE.GAC.IITG.TGLVDALTPNGDSNRALVASDC.LRS.PRDHIATASFA.HKNGSILIAAAWRGGGKRGVRCAACAVFRPPgSRAAPVQLTL
  473-  611 (179.50/102.75)	NIVEAVY...ERLTESFQRQPQ.PFQQyyyhnwlklRIALCSRVAGLTSSAASLCS.LQL.VLAGwSAAAASLRPDEKTEAALVSFAA.LSNmPDEHEEKNLLAlEAKAESLGEGATSAGSAWGALSAMQPLYRPL.QRALDTALTM
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08628 with Med16 domain of Kingdom Metazoa
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