<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08626

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMTETKPLAMATTNGLMDKSKELQKEILMEKLRSKTSQYKNLNETSKAVRMALLDKRWAVDSADRQILQKCLDSLQHCIKVGSLQSLIERLECLSRQLGLKFVVGTSGVNLFISSDMFYLEILVESLGSVKDVKIHHEGKIEQQSCEEMVASITRGDFADFTAQLEGLIAVYQLNAEKKVKCKAFSALQSLEEDLCTLRQVQSFIKDPWAQVHKSPIGFLQKRRGGHAMRLTYFVSPYELLDKEKGLQPLTTELLTLGKPAASSGLASLVAPSHTPVGYSATILLEGSTANKLQLCPIISSGQRSGKGNGPVYAPLVPQNSAMLPACFTLRLSQPMPLCTGLAKLIHATTEVEVSGDWGNAKPMLGLVAQQAYNKLAPGKIVELNLSKGLFVHLPEQTQCYFICESRGLEGCVVRSVPFTHPSHVPPLLACLRQQALFNTLIASCVRLQNKQVVEMEGVVILEVSAVSWQHISVSLEHPADESVATLELSLSEPAAPRAAVCTLHAPPSEHVDEYVTRVLQKSHSIPVTLRSLVKIWKMEAKQMNGNYSALDSNFSCDLGGLDPGGELRHEPAGLHGRALYPNNLNTHQGGAYLSEQQHHLSMICQDPNSSESKPQTDERKSKKRKSDNDLWSSSQKKGKQGITEAADSESDSDNSYVNEDDNTMNSNSTNEEGPESSVSQNEFASDLELSGMDPADALTVHDNRSSDMDNSNDGEPEEMIRNSFHKSEHKRQKLKNKESESRSSRSSASLLLDLTDGKSYMPSSVSITPIGSSSSSAANAASGTNLSSMLCLDRRPGIEIIPISSATPATLPSSITITPITSSQLKSLDSRSDKKSSKSSEERSKEKKKKRRRDDSMGPPEKVPPKQDPLTKPVSVSIKPTDGSPMRPSSPNSILRKFSPSPTHGRSVSITKSPSPSSVKSLGKPTGTSSHHSSPRHSPVQNSPKHLTGYSSPKNHSISSPKHSSSGSGKPSMSTLKSATTGSPSGKSGTTGYDLSKKISKDSYGSSSMTSRDKEKKHSGLSFSTSDRSSPKLKNQIKLKQLEITPVSCDSPVAEPLISPPNIEVNKSNTPSSQARNRKGSLSAVIDKLKSAHHSADTDIGSGKSGSSSSANKFSDPKTSAAGSSMKISESKNQEYMVKPSSDGMKITINKTRSKESSSSKLNYSSNKQSSPQLTPPSQGSPKTHTGLKPGVISGPASKKTQAMQSSKSGLSTSSTPPKNNTSPSESSSSSSVPKVPYSKSSSGGSTGINLSKSASKTSSGSPKNSNSDLSKIIRDREREKVRTKLMSNSEKSIFSSKSERHSSPSSSRDDVDGERFKASKEANFLVEGLIKPLDTSKFQIPKLKNQNTPDKNSPVSQYDSRSLVNDFARTLDQNKFPFSHFDNSNTRNAETLQKSSYTLNVPKPLLNMGAMSPKTVSSSKLDQADRADFSKNLEGLGKGESPQRSKDDSKEGFPGAFPMMPLDFKTDMAKGFPAPKGSSEDRKGADSCMKPPASGSVARSGATTPQEAAEMLLDFSSSSGSKVSGMVAVRPVYPASPALALQLAKSPAPSPLVAPSPHSNSPCITDDELMDEALVGPGK
Length1580
PositionMiddle
OrganismPapilio xuthus (Asian swallowtail butterfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Papilionidae> Papilioninae> Papilio.
Aromaticity0.04
Grand average of hydropathy-0.627
Instability index61.64
Isoelectric point9.21
Molecular weight169917.25
Publications
PubMed=26354079

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08626
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     251.18|      39|      39|     866|     904|       2
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  866-  904 (69.01/23.60)	KQDPLTK...PVSV.SI.......................K....PTDGSP....MRPSSP.NSILRKF...SP...SPTH
  906-  946 (33.30/ 7.49)	RSVSITKspsPSSVkSL......................gK....PT.GTS....SHHSSP.....RH....SPvqnSPKH
  950-  988 (44.49/12.53)	YSSPKNH...SISS.PK.......................H....SSSGSG.....KPS...MSTLKSAttgSP...SGKS
 1053- 1094 (34.34/ 7.95)	VAEPLIS...PPNI.EV.......................NksntPSSQAR....NRKGSL.SAVIDKL....K...SAHH
 1114- 1153 (38.34/ 9.76)	FSDPKTS...AAGS.SM.......................K....ISESKNqeymVKPSSD.GM...KI...TI...NKTR
 1221- 1283 (31.71/ 6.77)	NTSPSES...SSSS.SVpkvpysksssggstginlsksasK....TSSGSP....KNSNSDlSKIIRDR...ER...EKVR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.89|      27|      48|     761|     788|       3
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  761-  788 (42.84/29.53)	MPSSVSITPIGSSSSSAANAASGTNlSS
  811-  837 (46.05/27.34)	LPSSITITPITSSQLKSLDSRSDKK.SS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     183.38|      42|      48|    1421|    1465|       4
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 1295- 1339 (24.80/ 8.86)	.........................FSSKSE...RHSSPSSSRDDvD.........GERFKASkeanF...........LVEglikPLDtskF
 1343- 1409 (46.93/25.57)	KLKNQNTPDknspvsqydsrslvndFARTLD...QNKFPFSHFDN.SntrnaetlqKSSYTLN....V...........PKP....LLN...M
 1421- 1465 (71.39/52.84)	KLDQADRAD................FSKNLEglgKGESPQRSKDD.S.........KEGFPGA....F...........PMM....PLD...F
 1471- 1516 (40.26/20.53)	KGFPAP............................KGSSEDRKGAD.S.......cmKPPASGS....VarsgattpqeaAEM....LLD...F
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     220.09|      52|      54|     601|     654|       5
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  595-  648 (83.99/55.13)	EQQHHLSMICQDPNSSESKPQTDERKSKKRKSDNDLWSSSQK.KGKQgiTEAADS
  649-  697 (77.68/44.77)	ESDSDNSYVNEDDNTMNSN.STNEEGPESSVSQNEFASDLEL.SG....MDPADA
  705-  744 (58.41/31.44)	SSDMDN........SNDGEPEEMIRNS.FHKSEH....KRQKlKNKE..SESRSS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.42|      28|      56|     408|     435|       7
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  408-  435 (52.77/34.42)	LEGCVVR....SVPFTHPSH..VPPLLACLRQQA
  461-  494 (34.65/19.75)	LEVSAVSwqhiSVSLEHPADesVATLELSLSEPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     131.55|      24|      39|    1154|    1177|      10
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 1011- 1047 (27.11/ 8.70)	SRDKEKKHSGLsfSTSDRSSPKLknqiklkqleiTPV
 1154- 1177 (38.80/16.05)	SKESSSSKLNY..SSNKQSSPQL...........TPP
 1178- 1200 (35.93/14.25)	SQGSPKTHTGL..KPGVISGPA............SKK
 1201- 1218 (29.72/10.34)	TQAMQSSKSGL..STSS.................TPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.15|      22|    1284|     248|     273|      11
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  248-  273 (35.29/22.48)	PLTTEL.LTLGK.PAASsglaSLVAPS.H
 1535- 1559 (29.85/11.42)	PASPALaLQLAKsPAPS....PLVAPSpH
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08626 with Med1 domain of Kingdom Metazoa
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