<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08623

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMGIMYEKRPLKRPRLGPPDVYPQEPRQKEDELTSTNVKHGFSTTPQSSDEFGTARNFNYSASKIGQFFSSIISKKEELNTLPDCGRKRQQVNPKDNFWPATARTKPQIEAWFKDLAGSKPLSILAKKAPNFNKKEEIFMTLTEYQVAMPRAAWFIKLSSAYTVAVSEAKIKKRQLPDPTTDQIPKLAEHYQSAVPTNPLEKTPPSQSGQGTPSHNSSGNQPGGTTPNSTVPNSMHSPGNSSSMAESTDWRQALKLWNYCCRLARYMLDEGLLDRHDFLTWIIELLDKRGPEDGLLRLFLPLALQHMSEFVCCEGLSRRLATTCAKKAAAICSVLSDTTLRALNQPAVFTKTADGSDKVNGVPMSPAPENTNADVKPNVNQLKRSATPAESQGTPNPNHSIGTPNPNHSIGTPIPMGTPNPSQPMDVQVKEERGSPPRDVKTTLNTVITAALNPVQMGFSEILNCAYHRDIIIQLATVLQIICIECPTAMVWSGCGSSMQGSPLDLLPLPPSALPMPHMDSDVTEHHRKLVYEAEQEIAARSKKAESKWCTDKWQTSSQARVLAVLEALDRHCFDRVDPNNNLDTLYKEVFANCTPPSSKDSSTDTKDPEWACSYAVVRVLCEWAVCGARWGEHRAMAAAALLDRRQQLLHLHHDHHATGSDDKESISSGTGLYNGPPIFQNLLLRFLDNDAPVLDESPNAPPGNRQQFANLVHLFGELIRRDVFSHDAYMCTLISRGDLISPTEPTSSGGTSGHTVAPPVNSTGTNHNMDDDIFASIDLKPKMEENVRMEDDSKIDDDLDKLLQHIKEDQQNSMDAPDSPKDPGEPVHSLNSPMMGPSGMSIANMQSIGMGPMSVPGIRSSSACGGVGGVGGVGAGGASSAPVSRHYHYTMHFPLPPAEPEHTPHDANQRHILLYGVGRQRDDAKHAVKKMTKEICKLFSKKFSIDVAEGGKIKKHSRSEFNFEAVTQKFQAMSMYEQGAVSWAVGGAVCEALAAYAAGATTYLPQPEHVAFALDLMEIALNVHGLIETCIQVLKELSEVEGALITRGAPSSGLAAPRAYTSALALCTVGALRRYHSCLLLCVEQTSAVFEQLCRLVKCVVNPGDCGSAERCVLAQLHDLYKAAAHLCHAPYADTFANAYPKIKQALYSPVQPIPAKYKYDPEFLSEFFMNPRKGKIEIAWARQVAESPANRYNFVCSAMLAVCREVDNDRVNELGVVCAEMTAWCSALAPEWLGALVALCGAQHYPAPKPQVPQCASPQPNRPCSPPPPPPLYPDLLCHRDLHDAAAHDALAVFTCILVARHCFSLEDFVRHAALPSLVKACGGGGANNPPNAPSPETSARLTCHLLLRLFKTVDTPQPGLYSVSTSPGPGGGAAGVRLSCDRHLLAAAHKNIGVGPVLATLKAILMVSDLSARDGGKPSGKKSSELSHILGTSDTVPTDAQLDLMSGSGGVGSTLLDSSQSLSSLARRMLTEICCEEWVLQKCLQNPDELYLPDMLLDSMLTPRQAQRLLHMICYPDTASHTHPDLDQKTMITRLLENLEQWSLRMSWLDLQLMFNQFPPNSPELSAWLDTVARAVINVFQQPAPPPPDKDRTGTDRGVVSTSKWSESVWLVAPLVAKLPAAVQGRVLKQAGQILESGWGAGCSGGCAGGGGSGSHRDCKSHQSPSYKGSAGGGGGGKRGVSGMSGSGCACGGAAAVRLANEPLLSLVLTCLRNQDDQKESLLSSIHAQLAHYLGRAREQERAACGDAHDEVPADALLLRFSLAGGMFDAIRRSYQLTSDWAVLLTQLLAHQVLDAYNNTLCRSNLFTTLIDMLATLIHSTLAEGGDDNNRKHYQNLMKKLKKEIGDRHGPSVQSVRQLLPLSKNTIIEVIACEPLGCLVDQKGNKISGFDSDKKQGLRLTDKQRVSSWELVEGGRNPAPLSWAWFAATKIERKPLTYENAHRLLKYHTHSLVQPQSYYLESIPLPPEDLETNDNKQDNGSLDSSPTGAGKGRKMPCKNNKAKKPKVATPTNVGGGVGVGGGVGLAAPAQQPQFIQSQQQWFPPPGATYYNPPAAGVSPRSVTQASTTQCKQALSNMLRQRVPFNQMTQMQQNTGYPGAPHPRAPFPRQGMRQMQPNQMSQMQPNQMNPMSAMGNMGPMGQIGGVQMGPGQMGAGQMGSGQMGQSQMGGGQMGSGQMPGMGGQMFGGQYGGMQQGYGGYGQQMMQGSQQQMMNQGMGQSVNQMSQQVNQMGQSVNSIGQNVGQMSQGVGQGGQMPQGMGQMGQSMGQMGQAISQMGQMGQGGGMGQMNSQGSSMGPQGGNAMGGFLGQQSFQHQQNMMSGRASQEAFLAQQRQNARPQYMQAPNVTMGGMSGPAPPYPRNMQPQQSAQYGQQLTPQLRMRQQVLAMQQQQGPLVQHLQRQQYQPPY
Length2408
PositionKinase
OrganismPapilio xuthus (Asian swallowtail butterfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Papilionidae> Papilioninae> Papilio.
Aromaticity0.06
Grand average of hydropathy-0.426
Instability index51.64
Isoelectric point7.85
Molecular weight260714.48
Publications
PubMed=26354079

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08623
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     168.57|      18|      18|    2142|    2159|       1
---------------------------------------------------------------------------
 2130- 2149 (28.09/ 8.79)	NPmsamGNMGP..M..GQIGGVQM
 2150- 2169 (35.70/13.33)	GP....GQMGAGQMgsGQMGQSQM
 2170- 2184 (24.64/ 6.74)	GG....GQMGSGQM..PGMGG...
 2197- 2213 (28.20/ 8.85)	GY....GGYGQQMM...QGSQQQM
 2217- 2232 (26.80/ 8.02)	GM....GQ.SVNQM..SQQVN.QM
 2359- 2375 (25.14/ 7.03)	YP....RNMQPQQS..AQYGQ.QL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     130.76|      19|      19|    2268|    2286|       2
---------------------------------------------------------------------------
 2087- 2101 (22.29/ 6.59)	..NQMTQMQQNT..GYP.GA
 2102- 2117 (26.45/ 9.43)	PHPRAPFPRQG..MRQM..Q
 2260- 2272 (24.43/ 8.05)	....MGQMGQS..MGQM.GQ
 2273- 2290 (31.88/13.12)	AISQMGQMGQGGGMGQM.N.
 2337- 2355 (25.71/ 8.92)	ARPQYMQ.APNVTMGGMsGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.90|      10|      17|     387|     396|       3
---------------------------------------------------------------------------
  387-  396 (21.48/10.76)	PAESQGTPNP
  405-  414 (21.42/10.71)	PNHSIGTPIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.99|      15|      17|    2302|    2318|       4
---------------------------------------------------------------------------
 2304- 2318 (29.98/18.47)	MGGFLGQQSF..QHQQN
 2320- 2336 (23.01/ 6.57)	MSGRASQEAFlaQQRQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      87.40|      11|      17|    1671|    1681|       5
---------------------------------------------------------------------------
 1369- 1379 (20.23/ 6.55)	PGPGGGA.AGVR
 1648- 1659 (20.76/ 6.94)	GCAGGGGsGSHR
 1671- 1681 (23.11/ 8.63)	GSAGGGG.GGKR
 1690- 1700 (23.30/ 8.77)	GCACGGA.AAVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.74|      13|      16|     848|     861|      10
---------------------------------------------------------------------------
  848-  861 (21.07/16.78)	IGmGPMSVP.GIRSS
  867-  880 (19.66/ 9.02)	VG.GVGGVGaGGASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.74|      58|     166|    1010|    1072|      12
---------------------------------------------------------------------------
 1010- 1072 (84.60/63.79)	VAFALDLMEIALNVHGLIetCIQVLKELSEVEGALITR.GAPSSGLAaprAYTSALALCTVGAL
 1179- 1237 (101.14/61.86)	IAWARQVAESPANRYNFV..CSAMLAVCREVDNDRVNElGVVCAEMT...AWCSALAPEWLGAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.46|      22|      23|    1972|    1994|      13
---------------------------------------------------------------------------
 1972- 1994 (33.29/23.21)	LETNDNKQDNGSLdSSPTGAGKG
 1997- 2018 (40.17/23.59)	MPCKNNKAKKPKV.ATPTNVGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.44|      26|     503|    1288|    1330|      15
---------------------------------------------------------------------------
  562-  587 (47.50/19.77)	LAVLEAL..DRHCFDRVD..PNNNLDTLYK
 1292- 1321 (37.94/41.07)	LAVFTCIlvARHCFSLEDfvRHAALPSLVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      65.10|      15|      23|    1758|    1772|      16
---------------------------------------------------------------------------
 1758- 1772 (24.83/13.98)	ALLLRFSLAGGMFDA
 1784- 1798 (22.51/11.96)	AVLLTQLLAHQVLDA
 1801- 1814 (17.76/ 7.83)	NTLCRSNLFTTLID.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.38|      16|     166|    1711|    1727|      18
---------------------------------------------------------------------------
 1485- 1502 (26.17/10.82)	CLQNPDElyLPDMLLDSM
 1713- 1728 (28.21/12.61)	CLRNQDD..QKESLLSSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.83|      21|     357|    2027|    2047|      20
---------------------------------------------------------------------------
 2027- 2047 (42.83/23.81)	LAAPAQQPQFIQS.QQQWFPPP
 2386- 2407 (36.00/18.63)	LAMQQQQGPLVQHlQRQQYQPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08623 with Med12 domain of Kingdom Metazoa
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