<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08615

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMVPVAIEGCTQGAEGGGARGGSISLALLIDFIVQRTYDELTVLAELLPRKTDIERKIEIYKFSARTRQLFVRLLALVKWASSATKVDRSAHIMAFLDKQALLFVETADVLARVARETLVHARLPTFHMAAAVEVLTLGTYSRLPAVIRERLVPPPSLTPAERRTTLRALAHVVRQRLTTASLPTDVRNLKVENGRATFSVGQEFSVSLTVMGDAPNLPWRLLDIAILIQDYETGEGKPLVHTSQLAWLRGVAQARLAAAGLSGALTALRYFCRSLSLELLYTQTLRLCRDRLAKHLQVDKYIPGQKLQVSYWRELGCELGYRVIIGAEGESLCVWHVPALAGGERVAAALTPHAPSMERLLAHTVHVRSRQRLNDLKVLFNDLGVECTVSGWPCVLACSVVWPCLRAEQLLVSVGAHGGRLRARVPAYPATPRMPELAAALAAANLPLVKSLLTQLRFWLVARRCEKTLQHLPASVCEHLPFLHGPDHPLNKLSTDRLYVTLHRHTDYLLIVEMKEVAAGSTATTSNCSNSGSASSVALAFHLAGARRCTPDECEDESGATTSANASPASRAFLKLHSLVELDTFTLTHGPFTPLDTPGMQAGKRKLSAANSRAVRVRQPAYYLPELAHVVAAADERVPFVNLAQELAARGVTHGGVMPEWSGSSLGMRIVALPRPEEASERAAEALRMRLLAATIRLTTKNHARVWTAEIVFHGSPIRTPNPKEQGERRCVYLQYEWGTDAGRTADAFLADWAAIVHLHTLLYDFMLRPAQERETLWHGICIRSYTYRSLVLGFGVAQRATCVLQWAAGADRYTVATPAHQPAANAHHLLHHHLDNYINWHKDLMSFGVVLRETYAPLLALSRLPTLPQLGLHHVRTQMPTPTFTLLAHSWRKIRIIYAGAYSLEVGIRGGNMVTIRDGSYSKFDRATVVDEFAPALGLKTFLSRYVDDNISARLLAEEENPPSPMSPMPPGGLRFPAPLTPPQPHTPHSAPVTPHPASPAQHQMGGGSFNLTSPPGGGTGGSGAGVSASPASPLAPSPLAPAASPHPPPTSPYTPWLGSPSLPRPSPGHHPSPRHHLDHKGPQVSSSTTSGCRVGGMRGGAGGAAAPLTVAKLELLCTPSEPPPGAPPGPPLAPLQRFLACVYLKRTLPRFIQQEEFLTLVCMEATSVTFRCESAGLSARVALHPQHMQSLHLQLSVLPEHKEILSPDDLQVMEKFFETRVAIPPYRSSALHGWARAFGAPPVALPSLAALMRADLSPAALAASTPAPPLWQLQWALRIPPAAPQIVPAGHPAVLNAKNKILFFVSLLKKYKLQMNTSLQLETITSGESLMMYVLQICLTRGDTQLVLPLVYDSQNNSTQLADKRDAQPHLLAVNLHLKRFSEFNQPHSECTLWPAVRDLLTNFTLPQEAPPATAQPPP
Length1421
PositionTail
OrganismPapilio xuthus (Asian swallowtail butterfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Papilionidae> Papilioninae> Papilio.
Aromaticity0.07
Grand average of hydropathy-0.051
Instability index47.51
Isoelectric point9.25
Molecular weight154805.90
Publications
PubMed=26354079

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP08615
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     163.24|      26|      32|     966|     991|       1
---------------------------------------------------------------------------
  966-  984 (34.60/10.90)	.............................................PMSP.MPP..GGLRFPAP..LTPP
  985- 1017 (36.45/11.91)	QPHTPHS................................apvtphPASP.AQHqmGGGSFNL...TSPP
 1018- 1044 (29.04/ 7.84)	GGGTGGS...............................gagvsasPASP.LAP........SP..LAPA
 1046- 1075 (35.58/11.44)	SPHPPPT.....................................sPYTPwLGS..PSLPRPSPghHPSP
 1076- 1137 (27.56/ 7.03)	RHHLDHKgpqvsssttsgcrvggmrggaggaaapltvaklellctPSEP..PP..GAPPGP.P..LAPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     324.80|      78|      78|     278|     355|       2
---------------------------------------------------------------------------
  219-  266 (38.82/14.03)	......................................W...RLLDIAILIQDYETG.EGKPLVhtsqlAW.LRGVAQAR...LAAA.GLSGALT
  278-  355 (139.25/68.58)	ELLYTQTLRL.CRDRLAKHLQVDKYIPGQK...LQVSYW...RELGCELGYRVIIGA.EGESLC.....VWHVPALAGGE...RVAA.ALTPHAP
  358-  435 (105.04/50.00)	ERLLAHTVHVrSRQRL.NDLKVLFNDLGVE...CTVSGW......PCVLACSVVWPClRAEQLL.....V.SVGA.HGGRlraRVPAyPATPRMP
  437-  485 (41.69/15.59)	...............LAAALAAAN.LPLVKsllTQLRFWlvaRR..CEKTLQHL.....PASVC......EHLPFLHG.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     249.44|      58|      69|     731|     791|       3
---------------------------------------------------------------------------
  549-  585 (36.47/13.55)	............CTPDECED.ESGAT..............TSANAS.PAS..RAFLK..LHSLveLDTF..............................
  660-  725 (40.00/16.33)	..................EWsGSSLGmrivalprpeeaseRAAEALrMRLL.AATIR..LTT............KNHARVWtaeivfHGSPIRTPNPKE
  726-  790 (96.00/55.82)	Q.......gerrCVYLQYEW.GTDAG..............RTADAF.LADW.AAIVH..LHTL..LYDFMlrpAQERETLW......HGICIRSYTYRS
  791-  858 (76.97/38.04)	LvlgfgvaqratCV.LQ..W.AAGAD..............RYTVAT.PAHQpAANAHhlLHHH..LDNYI...NWHKDLMS......FGVVLRE.TYAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.43|      27|      27|     124|     150|       5
---------------------------------------------------------------------------
   91-  126 (31.30/13.18)	HIMAFLDkqaLLFVETADVLARVARETlvharlPTF
  127-  155 (41.40/19.63)	HMAAAVE...VLTLGTYSRLPAVIRER....lvPPP
  156-  184 (25.74/ 9.63)	SLTPAER...RTTL...RALAHVVRQRlttaslPT.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08615 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ARLLAEEENPPSPMSPMPPGGLRFPAPLTPPQPHTPHSAPVTPHPASPAQHQMGGGSFNLTSPPGGGTGGSGAGVSASPASPLAPSPLAPAASPHPPPTSPYTPWLGSPSLPRPSPGHHPSPRHHLDHKGPQVSSSTTSGCRVGGMRGGA
954
1103










Molecular Recognition Features






MoRF SequenceStartStop




NANANA