<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08589
Description |
Mediator of RNA polymerase II transcription subunit 13 |
Sequence | LDLSTEPLDRSSVLFVAYCLSQDQQWLLATFTDEQGGLLDHTLINIRVPAKYFSESENQRLQLTGSEKCMLSPRRIGLARLWDYIINLVGQTANPWRLVVGRIGRLGHGELKGWNGLLGRKSLQDVNKFFRDRCSACSISSSIPSHSTNNSSMINSTKPMLNLINSHSGANSCTHELPSLISACLVSVEPQSTFRVYPGFGLCSDEPWAYGGGGGGGGAGGMGSGSTGISGGSGGLNNGGNNASYGGSASSLNARMMSMLDTPTSSIDNPSATHILVFPTSTSASGVSEHEPSGLAEVIYGMGSDDMGVFDWLLPHDSGLDDLVPPNGSTAEMLADFGNPSELNFGLPDLGPPVCMNGVGDGIGKSSNARLGDASDGLHGHNDYVNSLHDGRGHGRMSDIMGLRGFESGLLDMEANQSSGMGGHMDELPFGHAVDPLNTMPFGMHDPTVNVSYYQRFYY |
Length | 459 |
Position | Middle |
Organism | Trichobilharzia regenti (Nasal bird schistosome) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Trematoda>
Digenea> Strigeidida> Schistosomatoidea> Schistosomatidae> Trichobilharzia.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.255 |
Instability index | 46.45 |
Isoelectric point | 5.02 |
Molecular weight | 48623.63 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364134
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GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP08589
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 49.15| 14| 15| 214| 228| 1
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214- 228 (24.57/11.98) GGGGG..AGGmGSGSTG
231- 246 (24.57/ 7.90) GGSGGlnNGG.NNASYG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 93.92| 24| 24| 303| 326| 2
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303- 325 (40.09/17.67) .......GSDDMGVFD..WLLPH..DSGL...DDLVP
326- 352 (32.29/12.94) P.....nGSTAEMLAD..FGNPSelNFGL...PDLGP
353- 386 (21.53/ 6.40) PvcmngvG.DGIGKSSnaRLGDA..SDGLhghNDYVN
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 47.84| 13| 15| 253| 265| 5
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253- 265 (24.07/16.92) NARMMSMLDTPTS
269- 281 (23.77/16.63) NPSATHILVFPTS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 68.99| 19| 290| 107| 125| 6
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107- 125 (36.94/20.57) GHGELKGWNGLLGRKS.LQD
393- 412 (32.05/16.92) GHGRMSDIMGLRGFESgLLD
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