<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08572

Description Mediator of RNA polymerase II transcription subunit 19
SequenceLSMAFPPNSPNNLQLPLKTSAATSWINKLKIVGSGQNWAVAPPFYLMSAEPPAPDATLTGAKNLIEHYGLESAYKKFCERKLRDELSAFLPHLSGNVNMPASEDGSGLLGLVERPPITGKELMPFAPSQLDHGFRLHPGPLPQEYMTLFMAPPANLNAGTAPGDNSVPTGGNATFPMKPNPGGSVSSQPLQAPASRGSSTPGGNMRKRRREIHRGGAPIPQSGGTPASFGGGSQQSSSAAGAVVAAHPHWGAVAPPRSLGAAVSLGGVGAAAPHSGPPPSMLLRGSEPMPSLQPSSCLPPPPPPPLLTSVQHLGASKPTSSSSLSSGGQVPHPPPVFSAHHHHNPATPASASLGPPSLKKVLRPDEQLMATGGGGSGSFFDSGRLSTPSSSGGGDYTGGGLDLEEERRRKKRKEKRYKKERE
Length422
PositionHead
OrganismSchistocephalus solidus (Tapeworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Cestoda> Eucestoda> Diphyllobothriidea> Diphyllobothriidae> Schistocephalus.
Aromaticity0.05
Grand average of hydropathy-0.490
Instability index70.74
Isoelectric point9.76
Molecular weight43608.74
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08572
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.38|      16|      23|     241|     259|       1
---------------------------------------------------------------------------
  241-  259 (27.63/11.51)	GAVVAAHPHWGavaPPRSL
  266-  281 (32.75/ 9.87)	GGVGAAAPHSG...PPPSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.04|      25|      27|     286|     312|       2
---------------------------------------------------------------------------
  286-  312 (44.97/16.09)	SEPMPSLQPSSCLPPPPPPPLLTSvqH
  316-  340 (33.07/ 7.35)	SKPTSSSSLSSGGQVPHPPPVFSA..H
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.09|      19|      23|     120|     142|       3
---------------------------------------------------------------------------
  120-  141 (30.97/16.62)	KELMPFAPsqlDHGFRLHPGPL
  172-  190 (31.13/ 7.45)	NATFPMKP...NPGGSVSSQPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.90|      43|     200|     150|     211|       4
---------------------------------------------------------------------------
  150-  211 (68.89/27.48)	MAPPANLNAGTAPGDNSVPTGGnatfpmkpnpggsvssqplQAPASRGSS..TPGG.NM.....RKRRRE
  362-  414 (58.01/21.85)	LRPDEQLMATGGGGSGSFFDSG.................rlSTPSSSGGGdyTGGGlDLeeerrRKKRKE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08572 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LPQEYMTLFMAPPANLNAGTAPGDNSVPTGGNATFPMKPNPGGSVSSQPLQAPASRGSSTPGGNMRKRRREIHRGGAPIPQSGGTPASFGGGSQQSSSAAGAVVAAHPHWGAVAPPRSLGAAVSLGGVGAAAPHSGPPPSMLLRGSEPMPSLQPSSCLPPPPPPPLLTSVQHLGASKPTSSSSLSSGGQVPHPPPVFSAHHHHNPATPASASLGPPSLKKVLRPDEQLMATGGGGSGSFFDSGRLSTPSSSGGGDYTGGGLDLEEERRRKKRKEKRYKKERE
141
422










Molecular Recognition Features






MoRF SequenceStartStop




1) FFDSGRLSTP
2) GDYTGGGLDLEEERRRKKRKEKRYKKERE
3) SLKKVLRP
379
394
357
388
422
364