<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08559

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMCASNQYSGMDGRSLENSYTNIFALTDLSGIQYRKYVLKEEKMYGVYEDPILASYSNCLKQNLMCAWVRTKKEKSEPQKPYLFSNFTRELWVFWYGSGDTVSWESCISPDLEKVSDGNWKKGLSYETRCIFFKALHNVLERKTCLVYSFAYENLFLVILSPYGISARLVVPSIGAKEPSNSQLDNWMRFYPIRSDGCDFNPLNFYLGPTGGNDFLTPTKSSPQQSTKNESGTKKSPNPSGSGEKLPKFVDVLLGGYRMRYPACFVLISEEVLESLLSDSGSRTSLASHASDSVPATSEHVSHPACQSLEPDVLGRFSNLSNVGKMSSHPRLPLTKLPSARRRRHLADRALRRALRSELSFLHSNSQSDRLENYLSYSHLPGLRLPSSSVPTFLPLHRRAFNVSHATHSFLDELDSYCDKTRSPPLTNTDPMMPTLSPQQPAPGHQTGHNSMQSATVTTTATSNVLSDSSVFTPPTCYVSQPPINRGSSVPTNLPPCLLNPATPYVRGSPTLKPDEVERGSMGKPPPCLAKVSPPRSVPPLPSVPGTASVDDGAAFPSPRPLYNSWLVEQAVRAIQRGSCVTHKQPLISLSRVDKMNILDSSLSAPSDPLIPGLVKPPNDGVIRLLKPGLHDQATDAYTFKSEDSDTPGHCYPYASNPSSVLSAYGKDPDSGSIDGFPSSEEHLRELDEDYLKPETASQILMRTRARRLPPGRSLFSSSGSGHLDPSELALMFPTPPSHDTHQPSPTDISMLVAAASTTLSLPGMTNSNPCTPTASAAAASSQATDLNRTALTSPCNPTSTVNMETVGHVFPHLTKFLFDQSGLDGASAQDWAFLRPTAPHFHIPSMYKLSMEEFLIYRESLPHSQPTYDHRSLSSDQLNTFNLTPQSTTSVPSATTLSQTVASSPAKSHGSRIAACEPLDPLKPVGSALKSQLTYALEVSETREADPLKLVLILSDSLLSLFRDHNFDSCNICECTSSVFGSEMEIYLPNPRLPQPVPPESAVSLRTPLSAAPCSAFSLEDQLNPTFSVSRSCTCGFSAFVNRRYATSGNLFYEDQLEVSALSIARFFLADRVQITDPPCPRLPPPPPLAQPSAYSRNDGWWAGRTCPNATHMALLHRWTCGSLEEFGVRLLVDWLNHDDLTATSTSKENLFDYTDACALTASAIEQSVLDPHSLDSSMEVDRMSSEDLPLDEATREEGIAFHPAFFHRASAEIPANKNDQIRLLESVRPWLQEAISSTRLLESNYKVDGPLTWKAFHQLAGRGANESCKPQPIPPFLVGGPDKDSLLISPFGVRDWDCLALAPLSRPKRVAFAVVLPAILAGPFGNASSGGGGGATSTSESPVNAYTSPRPSPLPTTAPMSALANFFRELSYAYENCRLGQHYPYFNPVAGSPETSFIPVCSPQDETDPDIATVSSLAPMSADLRRRLLRRLQTHTPSPEHFLQHLQFYVATAIHTTVKLLAERGVALPDGRRSSLVFPAFSSSASFAAAAAAAPAEGPQQSRLRSTVAAAAVSAAPRSPMPIASKTSPASGEGPLTTAYEGPPVDSDINTSLLIYLVNPFTQFADMDEEFQRLTTQALVGAGTRILSLLPDSWRQRVSFQLLPMEHTTSDYLPRLKSMALSVYSFIDRFIEPSLINANRTLTGMGPAAEKEFISATGEHLHARRVYSPAYTLAQRPDLWGQWCLHPSEPLENSSVLFVSYCLSEDQQWLLAACTDEQGSMLEHTFINIKMPEFMRCAVPPPPTPATPAAPEAASSTHLSSRRLGLACLWDFIISILATTSNPWRLVIGRLGRLGHGELKGWSGLLSSKNLQDVNQSLRANCALCATATSVSTTSARHMYNGKTTTTISLVAGGGVNSCVHEIPSVLSACLVSIEPQSTFRLFPFSDLHMGESWLSSGGVGGASGFGAPGGSSSGAGGGGVGGGGGGNAGAAYGAVGMCPFNSGFVSASGYAPSTTHILVFPTSPSARAQSEHDVFSRLTDLNLTDELLDYSNGIYPGLDDQAMNQSILDFPDPGERNSSVVQLRADSATIAEPDITGLSYDAACRVLAKHYLSHALLPFGVPDPQSQEDRSWKRAQVAGAAGAAPGWTTTPGSDPTEWECHKGDIKRSHCSLTLSPPVNHYTHWADHVV
Length2131
PositionMiddle
OrganismSchistocephalus solidus (Tapeworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Cestoda> Eucestoda> Diphyllobothriidea> Diphyllobothriidae> Schistocephalus.
Aromaticity0.08
Grand average of hydropathy-0.271
Instability index58.46
Isoelectric point5.99
Molecular weight230742.08
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08559
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     591.68|      99|     100|     638|     736|       2
---------------------------------------------------------------------------
  315-  418 (111.15/41.10)	R....F.SNLSNVGKM.SSHPRLP.L.TK.LPSARRRRHLADRALrrALRSELSF..LHSNSQSD....RlenylsyshlPGLRL...PSSSVP...TF...LPLHR...RAFNvSHAT..HSF..........LD..ELDSYCD
  419-  521 (94.75/33.90)	KtrspP.LTNTDPMMP.TLSPQQPaP.GH......QTGH.NSMQS..ATVTTTATsnVL....SDssvfT..........PPTCYvsqPPINRG..SSVptnLPPCL...LNPA.TPYV..RGSP....T....LKpdEVERGSM
  523-  603 (78.42/26.73)	K....P.PPC...LAKvSPPRSVP.P....LPSVPGTASVDDGA.....AFPSP......................................RPlyNSW...LVEQA..vRAIQ.RGSCvtHKQPlislSRVDKMN..ILDSSLS
  604-  691 (137.13/52.50)	A....P....SDPLIP.GLVK..P.P.NDGVIR.....LLKPG.L..HDQATDAY..TFKSEDSD....T..........PGHCY...PYASNP..SSV...LSAYG...KDPD.SGSI..DGFP....SSEEHLR..ELDEDYL
  692-  791 (138.72/53.20)	K....P.ETASQILMR.TRARRLP.P.GRSLFSSSGSGHLDPSEL..ALMFPTPP..SHDTHQP.....S..........PTDIS...MLVAAA..STT...LSLPGmtnSNPC.TPTA..SAAA....ASSQ.AT..DLNRTAL
  793-  839 (31.52/ 6.14)	S....PcNPTSTVNME.TVGHVFP.HlTKFLFDQSGLDGASAQDW..AFLRPTAP..........................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.38|      13|      15|    1674|    1686|       3
---------------------------------------------------------------------------
 1674- 1686 (28.14/17.76)	LAQRPDLWGQWCL
 1692- 1704 (21.24/11.39)	LENSSVLFVSYCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.65|      16|      20|    1489|    1504|       5
---------------------------------------------------------------------------
 1489- 1504 (28.35/14.39)	AAAAAAAP.AEGPQQSR
 1511- 1527 (24.31/11.18)	AAAVSAAPrSPMPIASK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.92|      17|      17|    1976|    1992|       6
---------------------------------------------------------------------------
 1976- 1992 (27.69/17.84)	VFSRLTDLNLTDELLDY
 1996- 2012 (30.22/20.23)	IYPGLDDQAMNQSILDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     227.99|      73|     584|    1261|    1355|       7
---------------------------------------------------------------------------
 1261- 1355 (108.03/82.72)	AGRGANeSCkPQPIPPFLvggpdkDSLLISpfgVRDWDCLALAPLSR....pkrvafavvlpAILAGPFGNASSG.GGGG.ATSTSESPVNAYTSPRPSPL
 1853- 1942 (119.96/52.84)	AGGGVN.SC.VHEIPSVL......SACLVS...IEPQSTFRLFPFSDlhmgeswlssggvggASGFGAPGGSSSGaGGGGvGGGGGGNAGAAYGAVGMCPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.71|      12|      20|    1132|    1143|       9
---------------------------------------------------------------------------
 1132- 1143 (22.72/12.27)	LVDWLNHDDLTA
 1151- 1162 (21.99/11.64)	LFDYTDACALTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.85|      44|     595|     261|     304|      10
---------------------------------------------------------------------------
  261-  304 (78.14/46.75)	PACFVLISEEVL...ESL............LSDSGSRTSLASHASDSVP.AT..SEHV.SHPA
  844-  906 (51.72/27.99)	PSMYKLSMEEFLiyrESLphsqptydhrslSSDQLNTFNLTPQSTTSVPsATtlSQTVaSSPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.99|      42|     664|    1073|    1119|      11
---------------------------------------------------------------------------
 1073- 1119 (77.38/56.36)	VQITDPPCPR..LPPPPPLAQPSAYSRndgwwAGRTCPNATHMALLHRW
 1728- 1771 (71.61/39.20)	INIKMPEFMRcaVPPPPTPATPAAPEA.....ASSTHLSSRRLGLACLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.92|      21|      21|    1558|    1578|      12
---------------------------------------------------------------------------
 1558- 1578 (37.40/25.92)	LVNPFTQFADM..DEEFQRLTTQ
 1580- 1602 (31.53/20.52)	LVGAGTRILSLlpDSWRQRVSFQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08559 with Med13 domain of Kingdom Metazoa
Unable to open file!