<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08557

Description Uncharacterized protein
SequenceMSKFPSLENRPLKKKGSWLPDVYTQQTGQPEDELSDDLVKDGFKYSKPVSFEYESAKNLFTAADMDSVWNLYYSVLVRKTHTASIFDSKRRNYTNFKDTVVPAIERNRSQVSDWFIELSGSGSLVNLSKHVPYYHKGKEEILQELLNNRVSVSRALWFINMSVIQSSALAENVKKKSRTTDPTSEWTSTLLKILDHVPLLEAALWKKLEFESACQKWDYLFRLLIAMYDNNLAEHCEVLKWFVTKIDAFYSVCLQSDLKDELPFCSPGEAKVWPSENDRLAVFKFLLPYVLRLGSRFTESELLTRRLLHWSCSAFSKFSFDCLQRLSPTTSLGRPEEYLELISCPHHRSILMSLSSLIASLTLSCPSAAVWNRISSKSVYPFLHGSPLDLLPCSLAFLPLPPGPEASKIRQCLMETEMALSERGKLAEAGWCLFPSSESPRGDECNESNAIYCLLEIGALARVLDILDRQDFSIAKEFCPLESLFKELFLVYKPDDPRCVYSLVTFLCQWVVSPTRTGLHRAVVVACLLEHFKSTYQTATQFFFQECLVNFLDQHAPSPAAGINTAYESSCFRSLVCLFGELIDRGIFDHDAFVRTFIARGIFDNNVHPYAQESFGCNPLSSSGQVGSLGNYNLPGNSTSRVSTMGCSILPATNLSGNFSIQSEVSEDNDRNSVENPDSVRSDFGALSSAPMSTRHNLSNLTSEHTNLNHHFQFLIHFPIPQDPSYAHEHNQRAQLLYGSMRARCRARDRIRKLVRDLTKVFTKNTYRLDVVHGEMGKRKKNKDRDKDSVLSSGANPTHFQGTTSQRTSKDTRPLEEIHDELLQRYRCLSYYDMECVISQTTPIFLQSLSGISGSGASVSGDTGDVYGIPDQHTLSLPLTSSPLQMAQNSGLGSLSLPTTSSHEPVYLPVPHTIFLFFDMIEASLNLTCLLDTVVQTLERLQAASPRSQFMSSYMSIVCLRIIGILRTHQPVLMTMSDLQLRVFSCLMYQVRQGKEKAHCKRCIVAYLNDLLKASCIVARENTRYPDPYSRNNVFLRPSEHFESVFVVSRNYIEELLTNTGDSRAAFRACIEDVRTNPQARVNFVYKALAAVSDSRTYEHLNYLFDLFAELMAQCIDFQTTWLEALSTIVAPRAYTDPSITTPDMPVWLENSNIWDNLASLIGTLLAKQCLPTSDFFVQFICQALAQGLDQGSAPVDSQHEPTVRFACHLLHRLFAAELCSTVHLATSAQPANADTEQTPSIPSYPPFRVSEPLLLTGALQKVTNVIFVDTLKMLMVHSDKGVPDADESETDKRLDDEGDGKTGSVRLSDQEDNSSDNDTRGDSASDDNADYGNSSVDTLEDLDTVDGPTKNRRKRRRVHLASKNKKRRGRGARKNAPSTHTANRRVLPNRIHPVTCNYLTTGTPPTDAEIKSLRLRDFAYLVLREVCVTPWVRETWYRISSLLLQEKVLIDKDFSRSQARHLLHILYQPHDVKWVDTALKNNSLADAMMVLLTNLSIWTLHSTWMEFELLYKQVCSTQEADPLPYVAQSIVENFNEQALEYLKGGSSDAASSGELPDGLPDIEVPKSDNIWLLLSLVAKLPTQLKVSIVKTTWDVSFRIFIIYLQNFLLPTQRLDFKLSILFILRVHCKILRSIKQFLRHKNDEDKERVVLRHSVILAHPAFSALLQVCMQETDSIDYLYEQVDFFLANAKETRDRMPENLRTRHVLQECLSLRLALVGRRLCTEMDAERISRWAVLLAQLIGFGVTEPHSNQTLFFTCLDMLHTLVHNLVAMNGAESKVCVNLNRRIRKELADRHFTAGIEYIKPLLFIGRSGYSFIVVNPLGGGPGGAGPGAGNRGEGGSGTGKLGGSLKSSNLKMGNKSSSAASSSSFSSSGCGGGRGLGSYGLTTGAGLKSFSRKRGYVFSGRERLAPWDVYDPNRRLQLLSTCGAVPTEASLTRVEEQANLLVSHEHPIRMRRSPEFYFHSIFPEPEHEDSVTAATTIASPENKNFLVLGSPSKRPPQQQRSSPEGGVQFNANPSVLAPNRPSAQLPPSSGLLTKTVNRSDMGRVFSNGGNQQQLPPQQPSVQLSASMSTPFVSHSGLMHSWDKVPGIRGTQNVVGLQNAQVPTGHPQQQQSPANGSVTRRKRSRTQLTAAATTANGQSNVALISRGGPLDFKPALSAEIGPSVAAGLTQQRSQSGEYSLSMAQPLNAKLTGRPSPPPDAMVFEEPRLPPSSMATFRSLQPPHTAVSMPPPTCTDSGNMMMMMDHFRGNVKLADAYVGMCGGVGNQQVNNFASSASNTATAAMASQQSSSGVKRKRSSVRRSSNSQQQKSSTPPVGSLYAAPDNGLGNLRAGVKSKQQQSLGGNSAYPSKPSMTATTDLYAFDAGGGSVVNTPRPGIWQHSQPPSSIMSQRGTPATVASTLPSVAGVGRGPPSQRPPPQVVGMYGGKQQHKPVDVGGIAMTPQKLMNQQQRPLHYYPVLVEDESPNFQQQQQQQQMMSQDPTGFVSNSQAIPGDYNSFPGVDNASASQDQMSGYISVTVSSTGDDPSGVGCGLPDSMSQQXQQPIRRGPLQQQPPNCPLMGMGQNAQHSVRYQQHQQSDQVLYGINSQQLQQQVPDPPPYPTSGRLQEQRQAKICMSQNVPLQTPDGIPPPGMQQQQPHLMHPPNSGVSWNSGYVFQPQRQNMPSVTFPKQHQVQQSLTVSPQQPPPSNLAPQHAQDQIPPSACHTVQYLHYEGYR
Length2722
PositionKinase
OrganismSchistocephalus solidus (Tapeworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Cestoda> Eucestoda> Diphyllobothriidea> Diphyllobothriidae> Schistocephalus.
Aromaticity0.08
Grand average of hydropathy-0.373
Instability index54.28
Isoelectric point8.17
Molecular weight301647.16
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08557
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     361.01|      43|      43|    2557|    2599|       1
---------------------------------------------------------------------------
 1995- 2053 (29.93/ 9.15)	..LGSP.............SKR...............PP......qqqrS..SP.................................EGGV.QFNANPSV.LapnrpsAQLPPSSGLlTKTVNrsdmgrvfS.
 2054- 2118 (25.18/ 6.41)	N.GGNQ..............QQ..............lPP..........Q..QPsvqlsasmstpfvshsglmhswdkvpgirgtqnVVGL..QNAQVPTGH......PQQQQS...................
 2377- 2396 (28.85/ 8.53)	.................................................N..TP.................................RPGI.WQHSQ..............PPSS......IM........SQ
 2414- 2449 (46.74/18.86)	G.RGPP.............SQR...............PP..............P................................qVVGMyGGKQQH.............KPVDVG.GIAMT........PQ
 2450- 2495 (46.37/18.65)	K.LMNQ..............QQ...............RPlhyypvlvedE..SP.................................NFQQ.QQQQQQ..........MMSQDPTG...FVSN........SQ
 2496- 2527 (31.22/ 9.90)	A.I...................................P..........GdyNS.................................FPGV..DNASAS..........QDQMSGYI.SVTVS........S.
 2557- 2594 (66.26/30.13)	...................QQQ...............PP..........N..CP.................................LMGM.GQNAQHSVRY......QQHQQSDQV.LYGIN........SQ
 2595- 2659 (46.10/18.49)	Q.LQQQvpdpppyptsgrlQEQrqakicmsqnvplqtPD..........G..IP.................................PPGM.QQQQPH..........LMHPPNSGV.SW..N........SG
 2660- 2689 (40.35/15.17)	YvFQPQ.............RQN...............MP...........................................................SVTF......PKQHQVQQS.L.TVS........PQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.98|      27|      43|    1830|    1860|       2
---------------------------------------------------------------------------
 1830- 1860 (36.12/31.54)	GAgpGaGNRGEGGSGTgKLGGSLKSSNLKMG
 1876- 1902 (52.86/27.70)	GC..G.GGRGLGSYGL.TTGAGLKSFSRKRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     176.71|      37|      43|    2297|    2333|       3
---------------------------------------------------------------------------
 2127- 2167 (29.71/10.79)	...RKRSRTQltaaaTTANGQSN........VALISRGGPLDFKP...................................alSAEIG
 2173- 2254 (31.69/12.04)	GLTQQRSQSG.....EYSLSMAQplnakltgRPSPPPDAMVFEEPrlppssmatfrslqpphtavsmppptctdsgnmmmmmDHFRG
 2297- 2333 (61.67/31.08)	GVKRKRSSVR.....RSSNSQQQ........KSSTPPVGSLYAAP.....................................DNGLG
 2338- 2373 (53.65/25.98)	GVKSKQQQSL.....GGNSAYPS........KPSMTATTDLYAF......................................DAGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.55|      25|      43|     503|     527|       4
---------------------------------------------------------------------------
  503-  527 (46.56/28.23)	LVTFLCQWVVSPTRTGL..HRAVVVAC
  548-  571 (42.96/25.41)	LVNFLDQHAPSPA.AGI..NTAYESSC
  575-  594 (21.03/ 8.21)	LVCLFGELI...DR.GIfdHDAFV...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     183.46|      54|      68|     201|     255|       5
---------------------------------------------------------------------------
  201-  255 (92.15/78.06)	EAALWKKLEFESACQKW..DYLFRLLIAMYDNNLAEHcEVLKWFVTKIDAFYSVCLQ
  269-  324 (91.31/70.66)	EAKVWPSENDRLAVFKFllPYVLRLGSRFTESELLTR.RLLHWSCSAFSKFSFDCLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.84|      16|      43|     764|     779|       6
---------------------------------------------------------------------------
  764-  779 (29.03/22.15)	KNTYR.LDVVHGEMGKR
  781-  796 (17.70/ 9.81)	KNKDRdKDSVLSS.GAN
  810-  825 (25.11/17.88)	KDTRP.LEEIHDELLQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.09|      28|      43|    1048|    1076|       7
---------------------------------------------------------------------------
 1048- 1076 (44.36/35.16)	VSRNYIEELLTNTGDSRAAFRA.CIeDVRT
 1092- 1120 (46.72/32.02)	VSDSRTYEHLNYLFDLFAELMAqCI.DFQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.80|      36|      67|    1408|    1446|       8
---------------------------------------------------------------------------
 1408- 1446 (53.51/45.94)	DAEIKSLRLRDfAYLV.LREVCVtpW.VRETWYRISSLLLQ
 1477- 1514 (55.28/35.00)	DTALKNNSLAD.AMMVlLTNLSI..WtLHSTWMEFELLYKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     259.70|      83|     534|     333|     437|       9
---------------------------------------------------------------------------
  333-  437 (118.88/129.64)	GRPEEY...LELISCPHHRSILMSLSSLiaSLTLSCPSAAVwnrissksvypFLHgspldlLPCSLaFLpLPPGPEASKIRQCLMETEMALSERGKlAEAGWCLFPSS
  868-  953 (140.82/91.33)	GIPDQHtlsLPLTSSPLQMAQNSGLGSL..SLPTTSSHEPV...........YLP......VPHTI.FL.FFDMIEASLNLTCLLDTVVQTLERLQ.AASPRSQFMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.19|      12|      20|     955|     966|      10
---------------------------------------------------------------------------
  955-  966 (21.28/12.05)	MSIVCLRIIGIL
  976-  987 (21.91/12.63)	MSDLQLRVFSCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.60|      36|     534|     629|     673|      11
---------------------------------------------------------------------------
  636-  673 (54.80/42.80)	GNSTSRVSTMGcsILPATNLSGNFSIQSEVSEDNDRNS
  675-  710 (61.81/28.06)	ENPDSVRSDFG..ALSSAPMSTRHNLSNLTSEHTNLNH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.66|      25|      88|    1697|    1721|      12
---------------------------------------------------------------------------
 1697- 1721 (41.79/25.45)	RMPENLRTRHVLQECLSLRLA.....LVGR
 1722- 1745 (25.34/12.32)	RLCTEMDAERIS......RWAvllaqLIGF
 1748- 1768 (30.53/16.46)	TEPHSNQT..LFFTCLDMLHT.....LV..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.94|      21|     300|     831|     861|      14
---------------------------------------------------------------------------
  839-  861 (28.90/42.67)	SQTTPiFLqSLSGISGSGASVSG
 2073- 2093 (43.05/22.34)	SMSTP.FV.SHSGLMHSWDKVPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.37|      43|      45|    1286|    1330|      15
---------------------------------------------------------------------------
 1288- 1330 (71.77/55.25)	ESETDKRLD.DEGDGKTGSVRLSDQEDNSSDNDTRGDSASDDNA
 1334- 1377 (67.60/44.57)	NSSVDTLEDlDTVDGPTKNRRKRRRVHLASKNKKRRGRGARKNA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08557 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DFKPALSAEIGPSVAAGLTQQRSQSGEYSLSMAQPLNAKLTGRPSPPPDAMVFEEPRLPPSSMATFRSLQPPHTAVSMPPPTCTDSGNMMMMMDH
2) HSDKGVPDADESETDKRLDDEGDGKTGSVRLSDQEDNSSDNDTRGDSASDDNADYGNSSVDTLEDLDTVDGPTKNRRKRRRVHLASKNKKRRGRGARKNAPSTHTANRRVL
3) NKNFLVLGSPSKRPPQQQRSSPEGGVQFNANPSVLAPNRPSAQLPPSSGLLTKTVNRSDMGRVFSNGGNQQQLPPQQPSVQLSASMSTPFVSHSGLMHSWDKVPGIRGTQNVVGLQNAQVPTGHPQQQQSPANGSVTRRKRSRTQLTAAATTANGQSNVALISRGG
4) QQRPLHYYPVLVEDESPNFQQQQQQQQMMSQDPTGFVSNSQAIPGDYNSFPGVDNASASQDQMSGYISVTVSSTGDDPSGVGCGLPDSMSQQXQQPIRRGPLQQQPPNCPLMGMGQNAQHSVRYQQHQQSDQVLYGINSQQLQQQVPDPPPYPTSGRLQEQRQAKICMSQNVPLQTPDGIPPPGMQQQQPHLMHPPNSGVSWNSGYVF
5) QRQNMPSVTFPKQHQVQQSLTVSPQQPPPSNLAPQHAQDQIPPSA
6) QVNNFASSASNTATAAMASQQSSSGVKRKRSSVRRSSNSQQQKSSTPPVGSLYAAPDNGLGNLRAGVKSKQQQSLGGNSAYPSKPSMTATTDLYAFDAGG
7) SVVNTPRPGIWQHSQPPSSIMSQRGTPATVASTLPSVAGVGRGPPSQRPPPQVVGMYGGKQQHKPVDVGGIAMTPQKLMN
8) VHGEMGKRKKNKDRDKDSVLSSGANPTHFQGTTSQRTSKDTRPLE
2157
1278
1989
2455
2665
2273
2374
772
2251
1388
2154
2662
2709
2372
2453
816










Molecular Recognition Features






MoRF SequenceStartStop




1) IRRGYL
155
160