<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08556
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MSTGVSTKERLLSHYETIDGILKDILDRVTRKAKFDEYEHLVRLLLEKDSEIKRTLKDAEEQLTIQKKIDKLRADCINSDAQIEACQKELKKSEFTALYYCRQKLDCMVNSIKNPIDLDELVQFSHWISFNYGVMAPDNWVQGDPRRPYPNKKEIRRGYLGHLDDSGNFRPSVNEEFAQAFPSTTNTPASSHPTPGCPGTNTTQSGATPAGHPIHAITNQSGFQTSTTQGPNVEQPGTI |
Length | 239 |
Position | Middle |
Organism | Schistocephalus solidus (Tapeworm) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Cestoda>
Eucestoda> Diphyllobothriidea> Diphyllobothriidae> Schistocephalus.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.722 |
Instability index | 38.27 |
Isoelectric point | 6.18 |
Molecular weight | 26882.84 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP08556
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 169.02| 36| 36| 165| 200| 1
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129- 161 (47.12/26.66) .SFNYGVMAPDNWVQGDPRRP.YPNKKEIRRGYLG.
165- 200 (64.46/38.88) DSGNFRPSVNEEFAQAFPSTTNTPASSHPTPGCPGT
204- 238 (57.44/33.93) QSGA.TPAGHPIHAITNQSGFQTSTTQGPNVEQPGT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 86.68| 27| 31| 11| 41| 2
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11- 37 (44.42/37.15) LLSHYETIDGILKDILDRVTRKAKFDE
45- 71 (42.26/23.97) LLEKDSEIKRTLKDAEEQLTIQKKIDK
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