<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08507

Description Uncharacterized protein
SequenceMHDISKCSDNLNFLDLLATVRADQIHSGSNNTRTGPYLIRYSTFLNHLQRIAIHCGLQLSSGPCSGGGTSAGALVWRLTSECFAVVVAATNNSITTSDSTYNNSPELTDLISIAAVYFEFNHDKAVPCPELATDLSMGKYSSLLQHVDNLLTIYAVPGDKIDRARTYLCLQALEKDLSMLTQAMRTDLENNIDAISTFRRAPNQKHDVFSMRDLVNRSLVGHFVGRTGGRLARLTYLVTSAQAMISNATRVIKNNLQMNSKSTYSSSIGCGSRDGLIGGYMARIGLCPRLSYVEDTSAVAQSTVQRLPFMPLVTLQKDAYGISVPHFAQPDEIKCISIEAEFVLHLDPPLPISTDAIQQLERTTGLSNTEIIDQKEEDIVLLILRKYKQEHLYGINTHLQNPNITQHSYQIKSDVKAYLVSSVPFTCSDQIGEIISILRKQASALAFYETFIVHPDKPVEKDDALTFSFNIKIMGGQMISLEFDDPNRLGAKIHASLHVRPFDVQCLELNYFSNTHDRLNSNCPSNDKEVDVMQLNKLDIESGGNLKANFSKILTKTHTLPIGFVWLLTQLQCPVHKQLVSLKLPVTNSYNSTENKESYSSVSQNQLTSLRTMLNRVKSSIIIRGANGTGGVLCGGDRKVSLDFESSSSFAAAQVFALNTPNYLNNAKKIPPLPPGVMATPPPAFTHLDTSSSDLGIISSLRPVNSQGKLRDMHPNSSLPAVSTNPSRGLRLDDLLVDSTFQTQQQLQQRNPPPISFSHSLPSYVSPIPGTHTTSLADVKEAYSDMINPNISTSNYLSLPTIHSSHKYGSSVLSGSNSIPSNLYNIPSMSVSASNSEATSSSAVVKSKSFTASPVSDNSRAPSASGSMLVNLLNEDSLSTSIPLVSPSSMTDRHHYNPSHSLTNLQNSPLTSAASSINVSNSRLPGMMLSNNSQLPSSDAQLPQGCGKPLSSSAPNLTPNXXXXXXXXXXXXXXXXXXXXXXXXQYPSVRNSSLITPNTGRTKHTSLKNSQASLTVNPTSNPKKPRKRRRGTVEGSFRCISSQKGNTPVPGVYSNYPTTKHQRVDTVLPTTSISLSGTYQRPTFNQTNSNFSSCSLPYVQQSTVASTVQSINMQIPNPSKSVYDFDDNPSSMFDVPVGNISSSNSLSFSSGSSLTSPKSGVSVNPLQSGSLAVSNANPISNFPVTTMMSSNSNLERTIERKTSLKMTIKTIPSQPITSTPKARVNFSQNEVDKYNKLQSVQSNSTPINTSDSGGTVHPAQPLPSVKKRKKRSVEGKPSAYMLQMLQLANCSISGSDASVTTTSVTTAASGVPSQSAITPLVLNNSGLKQIKSTNKLVGHGSVLVKKERKRRLGHGFTEKTHFSFIPNSNTHNQAQETADNANIPKLIKINRVSRPATSDVPKDNQTGSGTTPNLYSNCISMSPNSSSKKKVSALNSTPLGTGAGTSSGSDDMMVVKRLFSSSASPLVSGDKRKRNPETSKQSNNSQSAHPNSGTSSDSACISSPLLPSTSSDPPTNSNTSRKTPRPSLHTAPNLPRVPHTPTSKSQPVQQSSTLNYLSSSSVCTANPASVSVVGSSSGLIKGYKIPKKKSTTTGCLPSVPLSDASGDKSIGMLSTTLQQIQESVSSYRDTPDSQSPEKSDESSLTIVENMYPSSNDPNLEGVDPINAVVYNANINDAANNTDDNSSIPSDSVSGFTAPNTESCSQSILHPISLQSNSSVSGQCSQSSQQQFPRKSSVKSISDIVDKLRAKSTTSITSSTSTIISDSSNVGSSDTTAITSYEVKDSTINSMLSDNPSCVRSITKKNDEFQDQWRDNIFEKFCPSGTPTPHQTENGPNNICRSDSEVDLSTSIEHSEESVWTSGNKEPVYDKDERNISSSNLNAPMIHSNTQSISDSEGKQGKQQFEVCCLVLQ
Length1912
PositionMiddle
OrganismSchistosoma mattheei
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Trematoda> Digenea> Strigeidida> Schistosomatoidea> Schistosomatidae> Schistosoma.
Aromaticity0.05
Grand average of hydropathy-0.443
Instability index48.37
Isoelectric point8.79
Molecular weight203388.92
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08507
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|    1213.05|     190|     190|    1447|    1636|       1
---------------------------------------------------------------------------
  692-  859 (173.26/57.24)	..SSDLGI..I.....SSLRPVNS...qG..............KLR.DMHPNSSLP.........A...VSTN..PSRG....LRLDDLLVDS.T..F.........QT.QQQLQ.....QRN.PPPiSFsHSLPSyV.............................S.....PIPGTH..TTSLADVKEAysdminpniSTSNYLSLPTIH.SSHKYGSSVLSGS.NSIPSNlYN.IP...SMSVSASNS..EATSSSAVVKSK.....................SFTASPV.S..DNS
  863- 1088 (186.69/62.31)	SASGSMLVnlLNEDSLSTSIPLVSpssmT..............DRH.HYNP..SHS.........LTNLQNSP..LTSA....ASSINVSNSRlPgmM.LSNNSQLPSS.DAQLP.....QGC.GKP.LS.SSAPN.LtpnxxxxxxxxxxxxxxxxxxxxxxxxqyP.....SVRNSSliTPNTGRTKHT.........SLKNSQASLTVNpTSNPKKPR..KRR.RGTVEGsFRcISSQKGNTP..VPG..V.YSNYPTTKH.QRVDTVLP.TTSISL.....SGTYQRPTfN..QTN
 1090- 1255 (181.47/60.34)	.............NFSSCSLPYV......................Q.QSTVASTVQ.........SINMQIPN..PSKSvydfDDNPSSMFDV.P..V.GNISSSNSLSfSSGSS.....LTS.PKS.GV.SVNP..L...................................QSGSLA..VSNANPISNF.........PVTTMMSSNS....NLERTIERKTSL.KMTIK...T.IPSQPITST...PKarVNFSQNEVDK.....YNKLQ.SVQ.SN.....STPINTSD.S..GGT
 1257- 1428 (170.62/56.24)	HP................AQPLPS....V..............KKRkKRSVEGKPSaymlqmlqlANCSISGS..DASV....TTT.SVTTAA.S..G.VPSQSAITPL.VLNNSglkqiKST.NKL.VG.HGSVL.V.............................KkerkrRLGHGF..TEKTH................FSFIPNSN...THNQA.........QETADN.AN.IPKLIKINRVSRPA..T..SDVPKDNQTG..SGTTP.NLYSNC.....ISM..SPN.S..SSK
 1447- 1636 (309.96/108.85)	SGSDDMMV..VKRLFSSSASPLVS....G..............DKR.KRNPETSKQ.........SNNSQSAH..PNSG....TSSDSACISS.P..L.LPSTSSDPPT.NSNTS.....RKT.PRP.SL.HTAPN.L.............................P.....RVPHTP..TSKSQPVQQS.........STLNYLSSSSVC.TANPASVSVVGSS.SGLIKG.YK.IPKKKSTTTGCLPS..VPLSDASGDKSIGMLSTTLQ.QIQESV.....SSYRDTPD.S..QSP
 1639- 1835 (191.05/63.96)	SDESSLTI..VENMYPSSNDPNLE....GvdpinavvynaninDAA.NNTDDNSSI.........PSDSVSGFtaPN......TESCSQSILH.P..IsLQSNSSVSGQ.CSQSS.....QQQfPRK.S...SVKS.I.............................S.....DIVDKL..RAKSTTSITS.........STSTIISDSS.....N......VGSSdTTAITS.YE.V..KDSTINSMLSD..NP....SCVRSITKKNDEFQdQWRDNIfekfcPSGTPTPH.QteNGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.45|      13|     392|     117|     129|       2
---------------------------------------------------------------------------
  117-  129 (28.05/17.16)	YFEFNHDK.AVPCP
  511-  524 (23.40/12.96)	YFSNTHDRlNSNCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.13|      22|     401|     210|     231|       4
---------------------------------------------------------------------------
  210-  231 (39.91/30.73)	SMRDLVNR...SLVGHFVGRTGGRL
  609-  633 (33.22/24.12)	SLRTMLNRvksSIIIRGANGTGGVL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08507 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GFTEKTHFSFIPNSNTHNQAQETADNANIPKLIKINRVSRPATSDVPKDNQTGSGTTPNLYSNCISMSPNSSSKKKVSALNSTPLGTGAGTSSGSDDMMVVKRLFSSSASPLVSGDKRKRNPETSKQSNNSQSAHPNSGTSSDSACISSPLLPSTSSDPPTNSNTSRKTPRPSLHTAPNLPRVPHTPTSKSQPVQQSSTLNYLSSS
2) NPISNFPVTTMMSSNSNLERTIERKTSLKMTIKTIPSQPITSTPKARVNFSQNEVDKYNKLQSVQSNSTPINTSDSGGTVHPAQPLPSVKKRKKRSVEGKPS
3) SIEHSEESVWTSGNKEPVYDKDERNISSSNLNAPMIHSNTQSISDSEG
4) SIPLVSPSSMTDRHHYNPSHSLTNLQNSPLTSAASSINVSNSRLPGMMLSNNSQLPSSDAQLPQGCGKPLSSSAPNLTPNXXXXXXXXXXXXXXXXXXXXXXXXQYPSVRNSSLITPNTGRTKHTSLKNSQASLTVNPTSNPKKPRKRRRGTVEGSFRCIS
5) TTTGCLPSVPLSDASGDKSIGMLSTTLQQIQESVSSYRDTPDSQSPEKSDESSLTIVENMYPSSNDPNLEGVDPIN
1355
1177
1850
881
1591
1560
1278
1897
1041
1666










Molecular Recognition Features






MoRF SequenceStartStop




1) YFKEGEK
336
342