<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08504

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMNPSPAFSAANGTGSNLQAGNTASATWINKLKIVGRGQNWAVAPCEPFYLMGTEPPAPDAALTGAKNLIEHYGLENAYQKFCGKRLREELNAFLPHLSGNIDVPASVDESGLMSLIERPPIRGKELRPFAPSQLDHAFRLHPGPLPQEYASLFAAAPSKHIHRSVQDQQQLLGSNGTGTRVPATAVPGLSSSGSFHRRRRRHEVHRGALASGSDSSSSIGVPGVGGGNVSASPASFFTGPPTAYPQLGTVHTTTSLSSKPMLSQSHTLSSSLSITTSAPSTNVTMPNQSSTASDNNPVTQMVNHSKLVDHPPGLIPVSAPHSHLLGSSIPTSSTSSEPPPPPLLAPIHHHSNQKLPHSIQNTSSTLNPLYNSNTSDASLTPSKSVPPAPPVLHSIHPPNINPINLSVPSQPPSSHQFYHHHHRHQQQQQQLSSHLHHHQHPLSSMHHPHPITSSHSYPSSLSQNSSRSMSPIPMETNSSSPQSPDIYKIRRLDMTDEERRKKKRREKKRRKDKE
Length514
PositionHead
OrganismSchistosoma mattheei
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Trematoda> Digenea> Strigeidida> Schistosomatoidea> Schistosomatidae> Schistosoma.
Aromaticity0.04
Grand average of hydropathy-0.673
Instability index70.63
Isoelectric point9.82
Molecular weight55472.26
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08504
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.25|      14|      16|     275|     289|       1
---------------------------------------------------------------------------
  275-  289 (22.31/11.45)	TTSAPSTNVtMPNQS
  316-  329 (20.94/ 6.64)	PVSAPHSHL.LGSSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     310.80|      70|      70|     349|     418|       2
---------------------------------------------------------------------------
  133-  196 (74.28/19.94)	.....QLDHAFRLHPGPL....PQEYASLFAAAP...SKhihrSVQDQQQLLGSNGTGTRVP.ATAVPglSSSGSFH...
  349-  418 (128.30/39.09)	HHSNQKLPHSIQNTSSTL....NPLYNSNTSDASLTPSK....SVPPAPPVLHSIHPPNINPINLSVP..SQPPSSHQFY
  421-  487 (108.22/31.97)	HHRHQQQQ...QQLSSHLhhhqHPL.SSMHHPHPITSSH....SYPSS...LSQNSSRSMSPIPMETN..SSSPQSPDIY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08504 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NVSASPASFFTGPPTAYPQLGTVHTTTSLSSKPMLSQSHTLSSSLSITTSAPSTNVTMPNQSSTASDNNPVTQMVNHSKLVDHPPGLIPVSAPHSHLLGSSIPTSSTSSEPPPPPLLAPIHHHSNQKLPHSIQNTSSTLNPLYNSNTSDASLTPSKSVPPAPPVLHSIHPPNINPINLSVPSQPPSSHQFYHHHHRHQQQQQQLSSHLHHHQHPLSSMHHPHPITSSHSYPSSLSQNSSRSMSPIPMETNSSSPQSPDIYKIRRLDMTDEERRKKKRREKKRRKDKE
2) RSVQDQQQLLGSNGTGTRVPATAVPGLSSSGSFHRRRRRHEVHRGALASGSDSSSSIGVPGVG
228
163
514
225










Molecular Recognition Features






MoRF SequenceStartStop




1) PQSPDIYKIRRLDMTDEERRKKKRREKKRRK
481
511