<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08502

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSMSQLTGPNDASLEHCFTNIFALTDFSGIQYRKYILHTPKEYHDPLNDPIIKSYTLCQKYGVLSAWVRSKPESSDLSNPCAFSKFAKELWVFWYGNDDFPNADSCILPELRREDHGNWRQGLSYETRTVLFRALHNVVESVQYSVSFSFFLHGESTVCASLDIRQHAAVQRVGVEHIQSCITSQSTIPVILAPYGISAELTGFGFEKKDRDLMVESEAWSTFYPLRPSHECDPSMSGVTGLPFFAMATPTHQNPRQQNRFSNDKKRTVEEINRRCLDTPPKFVEVIVDGFRMRYPMCFVLITSVNDSPSQPEYNATPCGEAIHLSDVSGHNLSTNVSAPYMSNKCSMYNAHIPNKIKTSRFWRVNKRRKRPSIKMNTPGTSLLKAVIPNSSLQSDFLVDVRHIYLAGRTLQCASQHNRLPSIKPEWQSKRSHPTDKSDMGCSTNGLITSVSPEMCSLYIQDPCTILQCCCNRFSRVRRTSVGGSFHQQDPCIRHSLKSSIHFNVPLCDRPRTPLPMITTNLTATHDPSMPTLSPQQPAPNQNSNLSSNTLNELNNDFVCDQNTSQTTPSSTHLSTAPQPPSLLPKPESNSNLSSIVKIPNGLVTTDSPVSSDHQTQYAKMSARHIPIASVSVMKRNLFNTWLARHAAQELQKEPSSDTKRPSLCLSIPDRIEREQYICPEGIALQSALEQSSPSFPNYSIIDDNTSYKENNVTTDEYSFRNKRPRTAICRTDFNECSLNDGAQGITTDITNVNFTSANPYSPDMKVGVAECNGLIDDQYVNPGALETNTHSGLMHSNGSVMNNSSGTFSRNVGLITHRGVSLASSTGSGPIGPAELALMLPTPPSHDAPQPSPVDGVSVSTNRMNPSTTSVSTPGPGSPSVQTIQDSLSSNVTDTSSHSIPVPFQSANSPPSCQNQGLWHLAKLPCIQNLSSVSMESQEWSFVQPCAAYLGMTSNYQIPHDEISLFAKSLPRLKWSYDHRASNQKSVTSDCLDPHFTPNGLVVNTGNQSVTSKSWLTSPNSFPSTSLHRNVANTDNKPCSPQQLNESGTTYSITGFVKSADCTNPNTNYVEDYTEWLASLLETNGLLVNLILSDSMLNLFKDHNFDSCNICECTSSILGSEIGLYLSNSISTTSPCSRSGRTNTSTFGSHDLVGGSGFHFTRGCKCGFSAVMNQKYVVNGNLFYEDEIEVTRLSVRSSLSQNNENPYTRPPNYRTRPGWWVTSSHPSVSHLLLLQRIMSSVFEEFSVRQITDQLRWNMLSCDQVIKENKLEYDDACALIASAIRNSVETVRPRRVVGHVDNIDSIANGTPHPASETGAYIHPSFFLKAHSKMPQNQNDQIRLLTTMRPWLQEAISSTRMLESNYTVDGPLTWKAFHQLAGRGSDETCKPQPIPQLRVSSCDQENLLISPFALRDWDRLSLFPLSRPKRIAYAVILPSDSHIFSDLTSNIPNILMSEGTDANSSSTSNSLRRTLVDFLKELSHTYEACHLGQHFPYYKPEAGSPDTAFIPVFPNPERLSISESDNFVSIHPDLLKTLTEQLGNHSLCGESILRLIQNYACSSVNSAIAALKKHGVAVEFSFDTNLRSALFPPFESIKSEKPSVPVKISQDDIKLNIVNRLSVPSRMDSGCSVRYSNGDGSFTTSLDTSSWGAGSDVYLVIYILNPFCYLYDISMELGRLVMQSLVGSANHILNSLPESWRARVTTQILSVDHVMSDYLPRLRPLALAIYTSVNRFIEPSLINANRTLTGIGPAAEKEIISNDKDSFHKRTIFAPPYTLMNSRDVLSQLDISSEPIDRSSVLFVAYCLSQDQQWLLATFTDEQGGLLDHTLINIRVPTRYFTEIENQRFQPTESNKHILSPRRIGLARLWDYIINLISQTANAWRLVVGRIGRLGQGELKGWNGLLGRKSLQDVNKFFRERCTACSISSCVPSHSSSINNGSKPMLNLVNSFTGASSCTHELPSLISACLVSLEPQSTFRVYPGFGLCSDESWTYGGGGGGGNAGGGGGSGSAGSTGGSGGLSNGANSAFYGANASPLAMRMMPLLGTPTTSTETPSATHILVFPTSTSASGVSEHEPSGLAEVIYGMGSDDMNVFDWLLPNDPGLDDLVPPNGSTAEMLADFGNPSELNFGLSDLGPPVCVSGVNDGTGKSSNGRLGDGSDVLHGHNEYAVGFHDNRGHGCSDVMGLRGLDSGLLDLGPNHVSNVGGYLSEHSFGHAINPLNTMPFGIHDPTDEVGSLMQQPLAMGYYISTASAGPLPSWFWIACPHSKFQYPVCLKSALHLQTTLVGVDDAAAAAPPPTGGSSGPGVGPSSNRPGHLLDSSSTCDVLRYVLETYNALSWLTIDPTTNDRRTCLPIHILSLSQIYQAFEAFT
Length2373
PositionMiddle
OrganismSchistosoma mattheei
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Trematoda> Digenea> Strigeidida> Schistosomatoidea> Schistosomatidae> Schistosoma.
Aromaticity0.08
Grand average of hydropathy-0.327
Instability index50.74
Isoelectric point6.10
Molecular weight260053.92
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08502
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     145.88|      27|      27|    2101|    2127|       1
---------------------------------------------------------------------------
 2081- 2105 (40.14/21.13)	LAEVIYG.......MGS..DDMNVFDWLLP.............................NDPG
 2106- 2132 (46.80/26.08)	LDDLVPP.......NGSTAEMLADFGNPSE.............................LNFG
 2133- 2194 (20.81/ 6.75)	LSDLGPPvcvsgvnDGTGKSSNGRLGDGS.dvlhghneyavgfhdnrghgcsdvmglrgLDSG
 2195- 2216 (38.14/19.64)	LLDLGPN.......HVSNVG.....GYLSE.............................HSFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.82|      25|      27|     851|     876|       2
---------------------------------------------------------------------------
  851-  876 (41.30/29.11)	PQpSP.VDGV..SVSTNRMNPSTTSVSTP
  878-  905 (34.53/17.74)	PG.SPsVQTIqdSLSSNVTDTSSHSIPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.54|      17|      28|     426|     452|       4
---------------------------------------------------------------------------
  412-  430 (25.15/26.85)	LQCaSQHNRLPSIkPEWQS
  441-  458 (28.38/ 7.64)	MGC.STNGLITSVsPEMCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.44|      24|      27|     987|    1010|       5
---------------------------------------------------------------------------
  987- 1010 (44.52/24.36)	KS.VTSDCLDPHFTPNGLVVNTGNQ
 1015- 1039 (37.92/19.51)	KSwLTSPNSFPSTSLHRNVANTDNK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.45|      23|      32|    1907|    1936|       6
---------------------------------------------------------------------------
 1907- 1933 (37.79/31.38)	GRKSLQD.VNKFfrerCTACSISSCVPS
 1941- 1964 (38.66/15.32)	GSKPMLNlVNSF....TGASSCTHELPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.25|      21|      32|     348|     369|       7
---------------------------------------------------------------------------
  348-  369 (36.04/26.55)	SMYNAHIPNKIKTSRFWrVNKR
  383-  403 (35.22/20.81)	SLLKAVIPNSSLQSDFL.VDVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.65|      24|      32|     715|     746|       8
---------------------------------------------------------------------------
  715-  738 (44.89/43.94)	TTD..EYSFRNKRPRTAICRTDFNEC
  748-  773 (38.76/18.74)	TTDitNVNFTSANPYSPDMKVGVAEC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.60|      17|      85|     567|     589|       9
---------------------------------------------------------------------------
  521-  542 (22.99/ 6.26)	TNLTATHDPsmPTLSPQqpaPN
  573-  589 (32.61/10.39)	THLSTAPQP..PSLLPK...PE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.35|      18|      85|    1508|    1525|      10
---------------------------------------------------------------------------
 1428- 1453 (21.30/ 9.44)	PKRIAyavILPSDSHIfsdltSNIPN
 1500- 1515 (30.11/17.06)	PE..A...GSPDTAFI.....PVFPN
 1516- 1533 (31.94/18.64)	PERLS...ISESDNFV.....SIHPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.38|      15|      79|    1135|    1154|      12
---------------------------------------------------------------------------
 1118- 1142 (12.52/12.52)	SILGSEiGLylsnsistTSPCsRSG
 1147- 1169 (23.86/ 6.36)	STFGSH.DLvggsgfhfTRGC.KCG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.76|      16|      31|    1563|    1583|      16
---------------------------------------------------------------------------
 1563- 1583 (22.06/23.69)	SVNSaiaalKKHGVAVEFSFD
 1596- 1611 (27.70/16.65)	SIKS.....EKPSVPVKISQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.03|      15|      19|     794|     808|      18
---------------------------------------------------------------------------
  794-  808 (27.63/15.80)	GLMHSNGSVMNNSSG
  815-  829 (25.40/13.86)	GLITHRGVSLASSTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.72|      16|      32|    2227|    2246|      24
---------------------------------------------------------------------------
 2227- 2246 (25.86/24.51)	FGIHDPtdevGSLMQQPLAM
 2262- 2277 (34.85/21.54)	FWIACP....HSKFQYPVCL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08502 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DFVCDQNTSQTTPSSTHLSTAPQPPSLLPKPESNSN
2) ETPSATHILVFPTSTSASGVSEHEPSGLAEV
3) PIGPAELALMLPTPPSHDAPQPSPVDGVSVSTNRMNPSTTSVSTPGPGSPSVQTIQDSLSSNVTDTSSHSIPVPFQSA
4) PLPMITTNLTATHDPSMPTLSPQQPAPNQNSNLSS
5) SSIVKIPNGLVTTDSPVSSDHQTQYAKMSAR
6) YVNPGALETNTHSGLMHSNGSVMNNSSGTFSRNVGLITHRGVSLASSTGS
558
2054
832
515
595
781
593
2084
909
549
625
830










Molecular Recognition Features






MoRF SequenceStartStop




NANANA