<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08486

Description Uncharacterized protein
SequenceMHDISKFSDNLNFLDLLATVRADQIHSGSNSTRTGPYLIRYSTFLNHLQRIAIHCGLQLSSGPCSGGGTSAGALVWRLTSECFAVVVAATNNSITTSDSTYNNSPELTDLISIAAVYFEFNHDKAVPCPELATDLSMGKYSSLLQHVDNLLTIYAVPGDKIDRARTYLCLQALEKDLSMLTQAMRTDLENNIDAISTFRRAPNQKHDVFSMRDLVNRSLVGHFVGRTGGRLARLTYLVTSAQAMISNATGVIKNNLQMNSKSTYSSSIGCGSRDGLIGGYMARIGLCPRLSYVEDTSAVAQSTVQRLPFMPLVTLQKDAYGISVPHFAQPDEIKCISIEAEFVLHLDPPLPISTDAIQQLERTTGLSNTEIIDQKEEDIVLLILRKYKQEHLYGINTHLQNPNITQHSYQIKSDVKAYLVSSVPFTCSDQIGEIISILRKQASALAFYETFIVHPDKPVEKDDALTFSFNIKIMGGQMISLEFDDPNHLGAKIHASLHVRPFDVQCLELNYFSNTHDRLNSNCPSNEKEVDVMQLNKLDIESGGNLKANFSKILTKTHTLPIGFVWLLTQLQCPVHKKLVSMKLPVTNSYNSTENKESYSSVSQNQLTSLRTMLNRVKSSIIIRGANGTGGVLCGGDRKVSLDFESSSSFAAAQVFALNTPNYLNSAKKIPPLPPGVMATPPPAFTHLDTSSSDLGIISSLRPVNSQGKLRDMHSNSSLPAVSTNPSRGLRLDDLLVDSTFQTQQQLQQRNPPPISFSHSLPSYVSPIPGTHTTSLADVKEAYSDMINPNISTSNYLSLPTIHSTHKYGSSVLSGSNSIPSNLYNLPPMSVSASNSEATSSSAVVKSKSFTASPVSDNSRAPSTSGSMLVNLLNEDSLSTSIPLVSPSSMTDRHHYNPSHSLTNLQNSPLTSAASSINVSNSRLSGMMLSNNSQLPSSDAQLPQGCGKSLSSSAPNLTPNSSQYPSVRNSSLITPTTGRTKHTSLKNSQASLTVNPTSNPKKPRKRRRGTVEGSFRCISSQKGNTPAPGVYSNYPTTKHQRVDTVLPTTSISLSGTYQRPTFNQTNSNFPSCSLPYVQQSSIASTGQSINMQIPNPSKSVYDFDDNPSSMFDVPVGNISSSNSLSFSSSSSLTSPKSGVSVNPLQSGSLAVSNTNSISNFPVTTMMSSNSNLERTIERKTSLKMTIKTIPSQPITSTPKARVNFSQNEVDKYNKIQSAQSNSTPINTSDSGGTVHPAQPLPSVKKRKKRSVEGKPSAYMLQMLQLANSSISGSDASVTTTSVTTGASGVPSQSAITPLVLNNSGLKQIKSTNKLVGHGSVLVKKERKRRLGHGFTEKTHFSFIPNSNTYNQVQETADNSNIPKLIKINRVSRPPTSDVPKDNQTGSGTTPNLYSNCISMSPNSSSKKKVSALNSTPLGTGAGTSSGSDDMVAKRLFSSSASPLVSGEKRKRNPETSKQSNNSQSAYSNSGTSSDSAFISSPLLPSTSSDPPTNSNTSRKTPRPSLHAAPNLPRVPHTPTSKSQPVQQSNTLNYLSSSSASTANPASVSVVGSSSGLIKGYKIPKKKSTTTGCLPSVPLSDASGDKSVGMLSTTLQQIQESISSYRDTPDSQSPEKSDESSLTIVENMYPSSNDPNLEGVDPINAVVYNANINDAANNTDDNSSIPSDSVSGFTAPNTESCSQSILNPISLQSSSSVSGQCLQSSQQQFPRKSSVKSISDIVDKLRAKSTTSITSSTSTIISDSSNIGSSDTTAITSYEAKDSTINSMLSDNPSCARSITKKNDEFQDQWRDNIFEKFCPSGTPTPHQTENGQNNICRSDSEVDLSTSIENNEESLWTSGNKEQVYDKDERIISSSNSNAPMIHSNTQSISDLEGKQGKQQFECIKANTDTPASPTELLTTVPTSNSNMSSKIIPISPTSMKCLNSTGSISGSNMKPNIVRHSSLRFEKKSGSGRYSRLGGGVNGMMMHGGLVQRSNSDNYSHSSGVHGHSNRLPRGGMNNPRHNKAPNFKPPSNWGPMNMDYGNMGVAPSSSSSSAPGSSSIDINNSGNMGHWMMPSGGNINQNNPNMMQYNNPHSMQHHPYHSALNNRPMRPSYNMNGTAGHNPYNTGMMRGNKK
Length2116
PositionMiddle
OrganismSchistosoma margrebowiei
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Trematoda> Digenea> Strigeidida> Schistosomatoidea> Schistosomatidae> Schistosoma.
Aromaticity0.05
Grand average of hydropathy-0.512
Instability index47.26
Isoelectric point9.12
Molecular weight227794.46
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08486
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|    1359.37|     195|     195|     807|    1001|       1
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  670-  801 (87.49/24.50)	........................................................................................................................IPPLPPG...VM.A..................TP.P.....PA.FTH...LDTSSsdlgIISS.....LR...PVN...S.QGKLRDM..H....SNSS......LPA...VSTN.P..SR.GLRL..........DDLLVDS..TFQTQQQL...QQRNpppisfshslPSYVSPI...PG.THTTSLAdvkeaysdmiNPNIS.....TSNYLSLPT
  807- 1001 (319.72/112.25)	KYGSSVLSGS.NS.IP....S....NLYNLP..PMS.VSASNSEAT...SSSAVVKS...............KSFTASPVSDNSRAPSTSGSMLV.NL.LNE........DSLS....TSIPLVSPS...SM.TDR.............HHYNP.S.....HS.LTN...LQNSP....LTSA.....AS...SIN..VS.NSRLSGMMLS....NNSQ......LPS...SDAQLP..QGCGKSL..........SSSAPNL..TPNSSQYP...SVRN..........SSLITPT...TGRTKHTSLK..........NSQAS....LTVNPTSNPK
 1007- 1143 (175.20/57.64)	RRGT..VEGSfRC.IS....S....QKGNTP..APG.V............................................YSNYPTTKHQRVD.TV.LPT........TSIS....LSGTYQRPT...FN.QTN.............SNF.P.S.....CS.LPY...VQQSS....IAST.....GQ...SINmqIP.NPSKSVYDFD....DN.........PS...SMFDVP..VG...NI..........SSS........NSLSFS...S..S..........SSLTSPK...SGVSV...............................NP.
 1148- 1323 (159.36/51.66)	...SLAVSNT.NS.I.....S....N.FPVT..TMM.SSNSNLERTierKTSLKMTI...............KTIPSQPITSTPKAR.......V.NFsQNEvdkynkiqSAQS....NSTPINTSD...SG.GTV.............H...P.A.....Q............P....LPSV.....KK...RKK..RSvEGKPSAYMLQmlqlANSS......ISG...SDA......................SVTTTSV..TTGASGVP...S.............QSAITPL...V..LNNSGLK........qiKSTNK....LVGHGSVLVK
 1348- 1546 (191.59/63.84)	TYNQVQETAD.NSnIP....KlikiNRVSRP..PTSdVPKDNQTGS...GTTPNLYS...............NCISMSPNSSSKKK........V.SA.LNS........TPLG....TGAGTSSGS..dDM.VAK.............RLFSS.S.....ASpLVSgekRKRNP....ETSK.....QS.....N..NS.QSAYSNSGTS....SDSAfissplLPS...TSSDPP..TNSNTSR..........KTPRPSLhaAPNLPRVP...HT.P..........TSKSQPV...QQSNTLNYLS..........SSSAS.....TANPAS...
 1553- 1720 (108.88/32.59)	..SSGLIKG..YK.IPkkksT....TTGCLPsvPLS.......DAS...GD....KSvgmlsttlqqiqesiSSYRDTP...DSQSPEKS..........DE........SSL.....TIVENMYPS...SNdPNL.............EGVDP.I.....NA.V.....VYNAN....INDA.....AN...NTD...................DNSS......IPSdsvSGFTAPntESCSQSIlnpislqsssSVSGQCL..QSSQQQFPrksSVKS..........ISDI.............................................
 1722- 1907 (152.45/49.05)	....................D....KLRAKS..TTS.ITSSTSTII...SDSSNIGS...............SDTTA..ITSYEAKDSTINSMLSdN............................PScarSI.TKKndefqdqwrdnifEKFCP.SgtptpHQ.TEN...GQNNI....CRSD.....SEvdlSTS..IE.NNEESLWTSG....NKEQ......VYD...KDERII......SSS..........NSNAPMI..HSNTQ......SI.............SDLEGK...QGKQQFECIK.......antDTPASptelLTTVPTSNSN
 1954- 2103 (164.68/53.67)	RY..SRLGGG..........V....NGMMMH..GGL.VQRSNSDNY...SHSSGVHG...............HS......................NR.LPR........GGMNnprhNKAPNFKPP...S...................NWGPmN.....MD.YGN...MGVAP....SSSSssapgSS...SID..IN.N...SGNM......GHWM......MPS...G.GNIN..QNNPNMM..........QYNNPH...SMQHHPYH...SALN..........NRPMRPSynmNGTAGH.................................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08486 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISGSDASVTTTSVTTGASGVPSQSAITPLVLNN
2) ISNFPVTTMMSSNSNLERTIERKTSLKMTIKTIPSQPITSTPKARVNFSQNEVDKYNKIQSAQSNSTPINTSDSGGTVHPAQPLPSVKKRKKRSVEGKPSAY
3) NIFEKFCPSGTPTPHQTENGQNNICRSDSEVDL
4) NTPAPGVYSNYPTTKHQRVDTVLPTTSISLSGTYQRP
5) QVQETADNSNIPKLIKINRVSRPPTSDVPKDNQTGSGTTPNLYSNCISMS
6) SMKCLNSTGSISGSNMKPNIVRHSSLRFEKKSGSGRYSRLGGGVNGMMMHGGLVQRSNSDNYSHSSGVHGHSNRLPRGGMNNPRHNKAPNFKPPSNWGPMNMDYGNMGVAPSSSSSSAPGSSSIDINNSGNMGHWMMPSGGNINQNNPNMMQYNNPHSMQHHPYHSALNNRPMRPSYNMNGTAGHNPYNTGMMRGNKK
7) SSSKKKVSALNSTPLGTGAGTSSGSDDMVAKRLFSSSASPLVSGEKRKRNPETSKQSNNSQSAYSNSGTSSDSAFISSPLLPSTSSDPPTNSNTSRKTPRPSLHAAPNLPRVPHTPTSKSQPVQQSNTLNYLSSSSASTANPASVSVV
8) TSIENNEESLWTSGNKEQVYDKDERIISSSNSNAPMIHSNTQSISDLEGKQGKQQFECIKANTDTPASPTELLTTVPTSNSNMSSKIIPISP
9) TSIPLVSPSSMTDRHHYNPSHSLTNLQNSPLTSAASSINVSNSRLSGMMLSNNSQLPSSDAQLPQGCGKSLSSSAPNLTPNSSQYPSVRNSSLITPTTGRTKHTSLKNSQASLTVNPTSNPKKPRKRRRGTVEGSFRCISSQK
10) TTTGCLPSVPLSDASGDKSVGMLSTTLQQIQESISSYRDTPDSQSPEKSDESSLTIVENMYPSSNDPNLEGVDPIN
1270
1157
1792
1024
1351
1919
1403
1826
880
1568
1302
1258
1824
1060
1400
2116
1550
1917
1022
1643










Molecular Recognition Features






MoRF SequenceStartStop




1) IPKLIK
2) KKRKKR
3) LIKGYKIPKKK
1361
1244
1556
1366
1249
1566