<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08486

Description Uncharacterized protein
SequenceMHDISKFSDNLNFLDLLATVRADQIHSGSNSTRTGPYLIRYSTFLNHLQRIAIHCGLQLSSGPCSGGGTSAGALVWRLTSECFAVVVAATNNSITTSDSTYNNSPELTDLISIAAVYFEFNHDKAVPCPELATDLSMGKYSSLLQHVDNLLTIYAVPGDKIDRARTYLCLQALEKDLSMLTQAMRTDLENNIDAISTFRRAPNQKHDVFSMRDLVNRSLVGHFVGRTGGRLARLTYLVTSAQAMISNATGVIKNNLQMNSKSTYSSSIGCGSRDGLIGGYMARIGLCPRLSYVEDTSAVAQSTVQRLPFMPLVTLQKDAYGISVPHFAQPDEIKCISIEAEFVLHLDPPLPISTDAIQQLERTTGLSNTEIIDQKEEDIVLLILRKYKQEHLYGINTHLQNPNITQHSYQIKSDVKAYLVSSVPFTCSDQIGEIISILRKQASALAFYETFIVHPDKPVEKDDALTFSFNIKIMGGQMISLEFDDPNHLGAKIHASLHVRPFDVQCLELNYFSNTHDRLNSNCPSNEKEVDVMQLNKLDIESGGNLKANFSKILTKTHTLPIGFVWLLTQLQCPVHKKLVSMKLPVTNSYNSTENKESYSSVSQNQLTSLRTMLNRVKSSIIIRGANGTGGVLCGGDRKVSLDFESSSSFAAAQVFALNTPNYLNSAKKIPPLPPGVMATPPPAFTHLDTSSSDLGIISSLRPVNSQGKLRDMHSNSSLPAVSTNPSRGLRLDDLLVDSTFQTQQQLQQRNPPPISFSHSLPSYVSPIPGTHTTSLADVKEAYSDMINPNISTSNYLSLPTIHSTHKYGSSVLSGSNSIPSNLYNLPPMSVSASNSEATSSSAVVKSKSFTASPVSDNSRAPSTSGSMLVNLLNEDSLSTSIPLVSPSSMTDRHHYNPSHSLTNLQNSPLTSAASSINVSNSRLSGMMLSNNSQLPSSDAQLPQGCGKSLSSSAPNLTPNSSQYPSVRNSSLITPTTGRTKHTSLKNSQASLTVNPTSNPKKPRKRRRGTVEGSFRCISSQKGNTPAPGVYSNYPTTKHQRVDTVLPTTSISLSGTYQRPTFNQTNSNFPSCSLPYVQQSSIASTGQSINMQIPNPSKSVYDFDDNPSSMFDVPVGNISSSNSLSFSSSSSLTSPKSGVSVNPLQSGSLAVSNTNSISNFPVTTMMSSNSNLERTIERKTSLKMTIKTIPSQPITSTPKARVNFSQNEVDKYNKIQSAQSNSTPINTSDSGGTVHPAQPLPSVKKRKKRSVEGKPSAYMLQMLQLANSSISGSDASVTTTSVTTGASGVPSQSAITPLVLNNSGLKQIKSTNKLVGHGSVLVKKERKRRLGHGFTEKTHFSFIPNSNTYNQVQETADNSNIPKLIKINRVSRPPTSDVPKDNQTGSGTTPNLYSNCISMSPNSSSKKKVSALNSTPLGTGAGTSSGSDDMVAKRLFSSSASPLVSGEKRKRNPETSKQSNNSQSAYSNSGTSSDSAFISSPLLPSTSSDPPTNSNTSRKTPRPSLHAAPNLPRVPHTPTSKSQPVQQSNTLNYLSSSSASTANPASVSVVGSSSGLIKGYKIPKKKSTTTGCLPSVPLSDASGDKSVGMLSTTLQQIQESISSYRDTPDSQSPEKSDESSLTIVENMYPSSNDPNLEGVDPINAVVYNANINDAANNTDDNSSIPSDSVSGFTAPNTESCSQSILNPISLQSSSSVSGQCLQSSQQQFPRKSSVKSISDIVDKLRAKSTTSITSSTSTIISDSSNIGSSDTTAITSYEAKDSTINSMLSDNPSCARSITKKNDEFQDQWRDNIFEKFCPSGTPTPHQTENGQNNICRSDSEVDLSTSIENNEESLWTSGNKEQVYDKDERIISSSNSNAPMIHSNTQSISDLEGKQGKQQFECIKANTDTPASPTELLTTVPTSNSNMSSKIIPISPTSMKCLNSTGSISGSNMKPNIVRHSSLRFEKKSGSGRYSRLGGGVNGMMMHGGLVQRSNSDNYSHSSGVHGHSNRLPRGGMNNPRHNKAPNFKPPSNWGPMNMDYGNMGVAPSSSSSSAPGSSSIDINNSGNMGHWMMPSGGNINQNNPNMMQYNNPHSMQHHPYHSALNNRPMRPSYNMNGTAGHNPYNTGMMRGNKK
Length2116
PositionMiddle
OrganismSchistosoma margrebowiei
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Trematoda> Digenea> Strigeidida> Schistosomatoidea> Schistosomatidae> Schistosoma.
Aromaticity0.05
Grand average of hydropathy-0.512
Instability index47.26
Isoelectric point9.12
Molecular weight227794.46
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08486
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|    1359.37|     195|     195|     807|    1001|       1
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  670-  801 (87.49/24.50)	........................................................................................................................IPPLPPG...VM.A..................TP.P.....PA.FTH...LDTSSsdlgIISS.....LR...PVN...S.QGKLRDM..H....SNSS......LPA...VSTN.P..SR.GLRL..........DDLLVDS..TFQTQQQL...QQRNpppisfshslPSYVSPI...PG.THTTSLAdvkeaysdmiNPNIS.....TSNYLSLPT
  807- 1001 (319.72/112.25)	KYGSSVLSGS.NS.IP....S....NLYNLP..PMS.VSASNSEAT...SSSAVVKS...............KSFTASPVSDNSRAPSTSGSMLV.NL.LNE........DSLS....TSIPLVSPS...SM.TDR.............HHYNP.S.....HS.LTN...LQNSP....LTSA.....AS...SIN..VS.NSRLSGMMLS....NNSQ......LPS...SDAQLP..QGCGKSL..........SSSAPNL..TPNSSQYP...SVRN..........SSLITPT...TGRTKHTSLK..........NSQAS....LTVNPTSNPK
 1007- 1143 (175.20/57.64)	RRGT..VEGSfRC.IS....S....QKGNTP..APG.V............................................YSNYPTTKHQRVD.TV.LPT........TSIS....LSGTYQRPT...FN.QTN.............SNF.P.S.....CS.LPY...VQQSS....IAST.....GQ...SINmqIP.NPSKSVYDFD....DN.........PS...SMFDVP..VG...NI..........SSS........NSLSFS...S..S..........SSLTSPK...SGVSV...............................NP.
 1148- 1323 (159.36/51.66)	...SLAVSNT.NS.I.....S....N.FPVT..TMM.SSNSNLERTierKTSLKMTI...............KTIPSQPITSTPKAR.......V.NFsQNEvdkynkiqSAQS....NSTPINTSD...SG.GTV.............H...P.A.....Q............P....LPSV.....KK...RKK..RSvEGKPSAYMLQmlqlANSS......ISG...SDA......................SVTTTSV..TTGASGVP...S.............QSAITPL...V..LNNSGLK........qiKSTNK....LVGHGSVLVK
 1348- 1546 (191.59/63.84)	TYNQVQETAD.NSnIP....KlikiNRVSRP..PTSdVPKDNQTGS...GTTPNLYS...............NCISMSPNSSSKKK........V.SA.LNS........TPLG....TGAGTSSGS..dDM.VAK.............RLFSS.S.....ASpLVSgekRKRNP....ETSK.....QS.....N..NS.QSAYSNSGTS....SDSAfissplLPS...TSSDPP..TNSNTSR..........KTPRPSLhaAPNLPRVP...HT.P..........TSKSQPV...QQSNTLNYLS..........SSSAS.....TANPAS...
 1553- 1720 (108.88/32.59)	..SSGLIKG..YK.IPkkksT....TTGCLPsvPLS.......DAS...GD....KSvgmlsttlqqiqesiSSYRDTP...DSQSPEKS..........DE........SSL.....TIVENMYPS...SNdPNL.............EGVDP.I.....NA.V.....VYNAN....INDA.....AN...NTD...................DNSS......IPSdsvSGFTAPntESCSQSIlnpislqsssSVSGQCL..QSSQQQFPrksSVKS..........ISDI.............................................
 1722- 1907 (152.45/49.05)	....................D....KLRAKS..TTS.ITSSTSTII...SDSSNIGS...............SDTTA..ITSYEAKDSTINSMLSdN............................PScarSI.TKKndefqdqwrdnifEKFCP.SgtptpHQ.TEN...GQNNI....CRSD.....SEvdlSTS..IE.NNEESLWTSG....NKEQ......VYD...KDERII......SSS..........NSNAPMI..HSNTQ......SI.............SDLEGK...QGKQQFECIK.......antDTPASptelLTTVPTSNSN
 1954- 2103 (164.68/53.67)	RY..SRLGGG..........V....NGMMMH..GGL.VQRSNSDNY...SHSSGVHG...............HS......................NR.LPR........GGMNnprhNKAPNFKPP...S...................NWGPmN.....MD.YGN...MGVAP....SSSSssapgSS...SID..IN.N...SGNM......GHWM......MPS...G.GNIN..QNNPNMM..........QYNNPH...SMQHHPYH...SALN..........NRPMRPSynmNGTAGH.................................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08486 with Med1 domain of Kingdom Metazoa
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