<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08476

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMNPSPAFSAANGTGSNLQAGNTASATWINKLKIVGRGQNWAVAPCEPFYLMGTEPPAPDAALTGAKNLIEHYGLENAYQKFCGKRLREELNAFLPHLSGNIDVPASVDESGLMSLIERPPIRGKELRPFAPSQLDHAFRLHPGPLPQEYASLFAAAPSKHIHRSVQDQQQLSGSNATGTRVPATAVPGLSSSGSFHRRRRRHEVHRGALASGSDSSSSIGVPGVGGGNVSASPASFFTGPPTAYPQLGTVHTTTSLPSKPMLSQSHTLSSSLSITTSAPSTNITMPNQSSNASDNNPVTQMVNHSKLVDHPPGLIPVSAPHSHLLGSSISTSSTSSEPPPPPLLAPIHHHPNQKLPHSIQNTSSTLNPLYNSNTSDASLTPSKSVPPAPPVLHSIHPPSINPINSSVPSQPPSSHQFYHHHRHQQQQQQLSSHLHHHQHPLSSMHHHHPITSSHSYPSSLSQNSSRSMSPIPMETNSSSPQSPDIYKIRRLDMTDEERRKKKRREKKRRKDKE
Length513
PositionHead
OrganismSchistosoma margrebowiei
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Trematoda> Digenea> Strigeidida> Schistosomatoidea> Schistosomatidae> Schistosoma.
Aromaticity0.04
Grand average of hydropathy-0.686
Instability index72.55
Isoelectric point9.82
Molecular weight55347.05
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08476
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     215.96|      31|      33|     158|     188|       1
---------------------------------------------------------------------------
  158-  186 (38.73/11.85)	.............SKHIHRSVQDQQQLSGSNATGTRVPAT.AV
  187-  221 (32.00/ 8.50)	PG........lssSGSFHRRRRRHEVHRGALASGSDSSSSiGV
  245-  283 (35.12/10.06)	PQlgtvhtttslpSKPM...LSQSHTLSSSLSITTSAPST.NI
  316-  340 (34.57/ 9.78)	P...........vSAP.H.....SHLLGSSISTSSTSSEP.PP
  389-  411 (31.94/ 8.47)	P..................PVLHSIHPPSINPINSSVPSQ.P.
  443-  471 (43.61/14.28)	.............SMHHHHPITSSHSYPSSLSQNSSRSMS.PI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.07|       9|      15|     413|     423|       3
---------------------------------------------------------------------------
  413-  423 (17.05/14.23)	SSHqfYHHHRH
  431-  439 (21.02/10.09)	SSH..LHHHQH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08476 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HIHRSVQDQQQLSGSNATGTRVPATAVPGLSSSGSFHRRRRRHEVHRGALASGSDSSSSIGVPGVG
2) NVSASPASFFTGPPTAYPQLGTVHTTTSLPSKPMLSQSHTLSSSLSITTSAPSTNITMPNQSSNASDNNPVTQMVNHSKLVDHPPGLIPVSAPHSHLLGSSISTSSTSSEPPPPPLLAPIHHHPNQKLPHSIQNTSSTLNPLYNSNTSDASLTPSKSVPPAPPVLHSIHPPSINPINSSVPSQPPSSHQFYHHHRHQQQQQQLSSHLHHHQHPLSSMHHHHPITSSHSYPSSLSQNSSRSMSPIPMETNSSSPQSPDIYKIRRLDMTDEERRKKKRREKKRRKDKE
160
228
225
513










Molecular Recognition Features






MoRF SequenceStartStop




1) FYHHHR
2) PQSPDIYKIRRLDMTDEERRKK
3) REKKRR
417
480
504
422
501
509