<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08474

Description Uncharacterized protein
SequenceMVDAEFKRKLNEIREKVEDLFDFEGCKVGRGTYGSVYKAKLKDGTDSRDYALKQIEGTGLSMSACREIALLRELKHPNVITLQRVFLNHTTRRVWLLFDFAEHDLWHIIKFHRTTKANKSTVQVYGNMVKSLMYQILNGIHYLHDNWILHRDLKPANILVMGEGPDRGRVKIGDLGFARLFYQPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTYEPIFHCRQEDIKTSTPYHKEQLERIFRVMGYPPDDAWVDMKKMPDYHQLLRDSISKKTYGKYSLEGYFEEKKFKVDERELALLRRLLTMDPVKRLSAAEAMEDSYFKEGEKPNNDVFGNLPIPYPKREFISDDDSDDKQTGADKNVTQTGQQPNATGGRQTTAHPTGGSGMHTTHPQQQSQQQQRGNNAPQPQLPLPQQQQRTNGQPPPLNTQQQHMNSGQSNPHTRQLIHQQNNNDDIPSNKRIRLSQGNNETSIAPPPLPSSSTTSSSATVNSSGILHTNTNKPSITGQSQQLSNTTTTTTSGYANLQQQPMRNLPPGHMGHPGTSYPRYHH
Length565
PositionKinase
OrganismSchistosoma margrebowiei
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Trematoda> Digenea> Strigeidida> Schistosomatoidea> Schistosomatidae> Schistosoma.
Aromaticity0.08
Grand average of hydropathy-0.793
Instability index44.97
Isoelectric point8.99
Molecular weight64304.71
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08474
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     176.95|      47|      47|     363|     409|       1
---------------------------------------------------------------------------
  363-  409 (84.67/42.25)	DDDSDDK..QTGADKNVTQ..TGQQP.............NATGGRQ...T.TAHP..TGGSGMHTTHPQQ
  413-  459 (60.20/28.06)	Q.....Q..QRGNNAPQPQlpLPQQQ.............QRTNGQPpplN.TQQQ..HMNSGQSNPHTRQ
  468-  523 (32.08/11.77)	DDIPSNKriRLSQGNNETS..IAPPPlpsssttsssatvNSSGILH...TnTNKPsiTGQS.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     175.50|      45|      47|     140|     185|       2
---------------------------------------------------------------------------
  103-  137 (33.41/18.18)	....HDLWhIIkfHRTTK.AN.........KSTVQVyGNM...VKSLM.YQIL
  140-  185 (79.60/57.37)	IHYLHDNW.IL..HRDLKPANiLVMGEGPDRGRVKI.GDLG..FARLF.YQPL
  188-  234 (62.49/40.00)	LADLDPVV.VT..FWYRAPE..LLLGARHYTKAIDI.WAIGciFAELLtYEPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.63|      18|      35|     261|     294|       3
---------------------------------------------------------------------------
  261-  282 (30.79/50.82)	GYPPDDAW.VDMKKMPdyhqLLR
  297-  315 (26.84/ 7.79)	GYFEEKKFkVDERELA....LLR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08474 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AEAMEDSYFKEGEKPNNDVFGNLPIPYPKREFISDDDSDDKQTGADKNVTQTGQQPNATGGRQTTAHPTGGSGMHTTHPQQQSQQQQRGNNAPQPQLPLPQQQQRTNGQPPPLNTQQQHMNSGQSNPHTRQLIHQQNNNDDIPSNKRIRLSQGNNETSIAPPPLPSSSTTSSSATVNSSGILHTNTNKPSITGQSQQLSNTTTTTTSGYANLQQQPMRNLPPGHMGHPGTSYPRYHH
329
565










Molecular Recognition Features






MoRF SequenceStartStop




1) LPIPYPKREF
2) YPRYHH
351
560
360
565