<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08471

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSMSQLTGPNDASLEHCFTNIFALTDFSGIQYRKYILHTPKEYHDPLNDPIIKSYTLCQKYGVLSAWVRSKPESSDLSNPCAFSKFAKELWVFWYGNDDFPNADSCILPELRREDHGNWRQGLSYETRTVLFRALHNVVESVQYSVSFSFFLHGESTVCASLDIRQHAAVQRVGVEHIQSCVTSQSTIPVILAPYGLSAELTGFGFEKKDGDLMVESEAWSTFYPLRPSHECDPSMSGVTGLPFFAMATPTHQNPRQQNRFGSDKKRTVEEINRRCLDTPPKFVEVIVDGFRMRYPMCFVLITSVNDSPSQPEYNPTPYGEAIHLSDVSGHNLSTNVSAPYMSNKCSMYNAHIPNKIKTSRFWRVNKRKKRPSIKMNTPGTSLLKAVIPNSSLQSDFLVDVRHIYLAGRTLQCASQHNRLPSMKPEWQSKRSHSTDKSDMGCSTDGLITSVSPEMCSLYIQDPCTVLPCCCNRFSRVRRTSVGGSFHQQDPCIRHSLKSSIHFNVPLCDRPRTPLPMITTNLTATHDPSMPTLSPQQPAPNQNSNLSSNTLNELNNDFVCDQNTSQTTPSSTHLSTAPQPPSLLPKPESNSALSSIVKIPNGLVTTDSPVSSDHQTQYAKMSARHIPIASVSVMKRNLFNTWLARHAAQELQKEPSSDIKRPSLCLSIPDRIEREQYICPEGIALQSALEQSSPSFPNYSIIDDNTSYKENNVTTDEYSFRNKRPRTAICRTDFNECSLNDGAQGITTDITNVNFTSANPYSPDMKVGVTECNGLIDDQHINPGALETNTHSGLMHSNGSVMNNSSGTFSRNVGLITHRGVSLASSTGSGPIGPAELALMLPTPPSHDAPQPSPVDGVSVSTNRMNPSTTSVSTPGPGSPSVQTIQDSLSSNVTDTSSHSIPVPFQSANSPPSCQNQGLWHLAKLPCIQNLSSVSMESQDWSFVQPCAAYLGMTSNYQIPHDELSLFAKSLPQLKWSYDHRASNQKSVTSDCLDSHFTPNGLVVNTGNQSVTSKSWLTSPNSFPPTSLHRNVSNTDNKPCSPQQLNESGTTYSITGFVKSADCMNSNTNYVEDYTEWLASLLETNGLLVNLILSDSMLNLFKDHNFDSCNICECTSSILGSEIGLYLSNSVSTTSPCSRSGRTNTSTFGSHDLVGGSGFHFTRGCKCGFSAVMNQKYVVNGNLFYEDEIEVTRLSVRSSLSQNNENPYTRPPNYRTRPGWWVTSSHPSVSHLLLLQRIMSSVFEEFSVRQITDQLRWNMLSCDQVIKENKLEYDDACALISSAIRNSVETVRPRRVVGHVDNIDSIANGTPHPASETGAYIHPSFFLKAHSKMPQNQNDQIRLLTTMRPWLQEAISSTRMLESNYTVDGPLTWKAFHQLAGRGSDETCKPQPIPQLRVSSCDQENLLISPFALRDWDRLSLFPLSRPKRIAYAVILPSDSHILSDLTSNILMSEGTDANSSSTSNSLRRTLVDFLKELSHTYEACHLGQHFPYYKPEAGSPDTAFIPVFPNPERLSISESDNFVSIHPDLLKTLTEQLGNHSLCGESILRIIQNYACSSVNSAIAALKKHGVAVEFSSDTNLRSALFPPFESIKSEKPSVPVKISQDDIKLNIVNRLSVPSRMDSGCSVRYSNGDGSFTTSLDTSSWGAGSDVYLVIYILNPFCYLYDISMELGRLVMQSLVGSANHILNSLPESWRARVTTQILSVDHVMSDYLPRLRPLALAIYTSVNRFIEPSLINANRTLTGIGPAAEKEIISNDKDGFHKRTIFAPPYTLMNSRDVLSQLDISSEPIDRSSVLFVAYCLSQDQQWLLATFTDEQGGLLDHTLINIRVPTRYFTEIENQRFQPTESNKHILSPRRIGLARLWDYIINLVSQTANAWRLVVGRIGRLGQGELKGWNGLLGRKSLQDVNKFFRERCTACSISSCVPSHSSSINNGSKPMLNLVNSFTGASSCTHELPSLISACLVSLEPQSTFRVYPGFGLCSDESWTYGGGGGGGNAGGGGGSGSAGSAGGSGGLSNGANNAFYGANASPLAMRMMSLLDTPTTSTETPSATHILVFPTSTSASGVSEHEPSGLAEVIYGMGSDDMNVFDWLLPNDPGLDDLVPPNGSTAEMLADFGNPSELNFGLSDLGPPVCVSGVNDGTGKSSNGRLGDGSDVLHGHNEYAVGFHDNRGHGCSDVMGLRGLDSGLLDLGPNHVSNVGGYLSEHSFGHAINPLNTMPFGIHDPTDEVGSLMQQPLAMGYYISTASAGPLPSWFWIACPHSKFQYPVCLKSALHLQTTLVGVDDAAAAAPPPTGGSSGPGVGPSSNRPGHLLDSSSTCDVLRYVLETYNALSWLTIDPTTNDRRTCLPIHILSLSQIYQAFEAFT
Length2370
PositionMiddle
OrganismSchistosoma margrebowiei
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Trematoda> Digenea> Strigeidida> Schistosomatoidea> Schistosomatidae> Schistosoma.
Aromaticity0.08
Grand average of hydropathy-0.327
Instability index51.06
Isoelectric point6.03
Molecular weight259471.16
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08471
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.89|      18|      19|    1983|    2000|       1
---------------------------------------------------------------------------
 1983- 2000 (37.75/18.53)	GLCSDESWTYGGGGGGGN
 2004- 2021 (33.14/15.30)	GGGSGSAGSAGGSGGLSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.27|      13|      94|    2120|    2132|       2
---------------------------------------------------------------------------
 2120- 2132 (24.36/15.58)	FGNPSELNFG.LSD
 2146- 2159 (18.91/ 9.86)	TGKSSNGRLGdGSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.84|      20|      94|    1040|    1063|       3
---------------------------------------------------------------------------
  738-  760 (27.99/11.17)	CS...LNDgaQGITTDITNVnFTSAN
 1041- 1063 (31.85/30.68)	CSpqqLNE..SGTTYSITGF.VKSAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.43|      26|      26|     851|     876|       4
---------------------------------------------------------------------------
  579-  601 (30.85/11.92)	PQP..P.......SLLPKPESNSALSsiVKIP
  851-  876 (49.14/23.89)	PQP.SP.VDGV..SVSTNRMNPSTTS..VSTP
  878-  905 (22.44/ 6.42)	..PgSPsVQTIqdSLSSNVTDTSSHS..IPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.87|      41|     100|    1942|    1982|       5
---------------------------------------------------------------------------
 1942- 1982 (75.19/42.18)	MLNLVNSFTGAS...SCTHEL..PSLISACLVS.LEPQSTFRVYPGF
 2039- 2085 (58.68/31.13)	MMSLLDTPTTSTetpSATHILvfPTSTSASGVSeHEPSGLAEVIYGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     335.64|     142|     482|    1083|    1234|       6
---------------------------------------------------------------------------
 1083- 1182 (126.40/90.51)	.................................................................................................................................................................................................................................................................................................................................................................................................LETNGLLVNLiLSDSML..NLFKDhnFDSCNICECTSSILGSEIGLYLsNSVSTTSPCSRSGRTNTSTFGSHDlvGGSGFHFTRGCKCGFSAVMNQKYVVNG
 1183- 1234 (36.47/24.59)	NLFYEDEIEVTRLSVRSSLSQNNENPYTRPPNYRTRpgwwVTSSHPSVSHLL...................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1568- 1663 (130.49/74.31)	....................................................llqrimssvfeefsvrqitdqlrwnmlscdqvikenkleyddacalissairnsvetvrprrvvghvdnidsiangtphpasetgayihpsfflkahskmpqnqndqirllttmrpwlqeaisstrmlesnytvdgpltwkafhqlagrgsdetckpqpipqlrvsscdqenllispfalrdwdrlslfplsrpkriayavilpsdshilsdltsnilmsegtdanssstsnslrrtlvdflkelshtyeachlgqhfpyykpeagspdtafipvfpnperlsisesdnfvsihpdllktlteqlgnhslcgesilriiqnyacssvnsaiaaLKKHGVAVEF.SSDTNLrsALFPP..FESIKSEKPSVPVKISQDDIKL.NIVNRLSVPSRMDSGCSVRYSNGD..GSFTTSLDTSSWGAGSDVYLVIYILNP
 1665- 1712 (42.29/16.71)	CYLYDISMELGRLVMQSLVGSANHILNSLPESWRAR....VTTQILSVDHVM...................................................................................................................................................................................................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.25|      22|      26|     986|    1010|       7
---------------------------------------------------------------------------
  989- 1010 (42.82/26.04)	VTSDC.LDS..HFTPNGL...VVNTGNQ
 1012- 1039 (25.43/ 6.32)	VTSKSwLTSpnSFPPTSLhrnVSNTDNK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.60|      16|      18|    1492|    1509|       8
---------------------------------------------------------------------------
 1492- 1509 (25.97/24.74)	FPyyKPE..AGSPDTAFIPV
 1510- 1527 (24.63/13.91)	FP..NPErlSISESDNFVSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     186.11|      53|     155|     248|     303|      11
---------------------------------------------------------------------------
  248-  303 (93.45/57.91)	MATPTHQNPRQQNRFGSDKKrtvEEINRRCLDTPPKFVEVIVDGF..RMRYPMCFVLI
  407-  461 (92.66/50.93)	LAGRTLQCASQHNRLPSMKP...EWQSKRSHSTDKSDMGCSTDGLitSVSPEMCSLYI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.07|      33|      96|    1249|    1297|      12
---------------------------------------------------------------------------
  774-  809 (54.14/22.17)	NGLIDDQHINPGALETNTHSGLMhsnGSVMNNSSGT
 1259- 1291 (56.93/33.26)	NMLSCDQVIKENKLEYDDACALI...SSAIRNSVET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.86|      27|      32|    2212|    2243|      18
---------------------------------------------------------------------------
 2212- 2242 (46.89/28.88)	FGHAINPLNTMP....FGIHDPtdevGSLMQQPLA
 2243- 2273 (49.98/26.62)	MGYYISTASAGPlpswFWIACP....HSKFQYPVC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.53|      20|    1174|     137|     157|      19
---------------------------------------------------------------------------
  137-  157 (32.26/23.85)	HNVVESVQYsVSFSFFLHGES
 1313- 1332 (38.28/23.84)	HPASETGAY.IHPSFFLKAHS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08471 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DFVCDQNTSQTTPSSTHLSTAPQPPSLLPKPESNS
2) IDDQHINPGALETNTHSGLMHSNGSVMNNSSGTFSRNVGLITHRGVSLASSTGS
3) PIGPAELALMLPTPPSHDAPQPSPVDGVSVSTNRMNPSTTSVSTPGPGSPSVQTIQDSLSSNVTDTSSHSIPVPFQSA
4) PLPMITTNLTATHDPSMPTLSPQQPAPNQNSNLSS
558
777
832
515
592
830
909
549










Molecular Recognition Features






MoRF SequenceStartStop




NANANA