<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08456

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMNPSPAFSAANGTGSNLQAGNTASATWINKLKIVGRGQNWAVAPCEPFYLMGTEPPAPDAALTGAKNLIEHYGLENAYQKFCGKRLREELNAFLPHLSGNIDVPASVDESGLMSLIERPPIRGKELRPFAPSQLDHAFRLHPGPLPQEYASLFAAAPSKHIHRSVQDQQQLSGSNGTGTRVPATAVPGLSSSGSFHRRRRRHEVHRGALASGSDSSSSIGVPGVGGGNVSASPASFFTGPPTAYPQLGTVHTTTSLSSKPMLSQSHTLSSSLSITTSAPSTNVTMPNQSSTASDNNPVTQMVNHSKLVDHPPGLIPVSAPHSHLLGSSISTSSTSSEPPPPPLLAPIHHHSNQKLPHSIQNTSSTLNPLYNSNTSDASLTPSKSVPPAPPVLHSIHPPSINPINSSVPSQPPSSHQFYHHHHRHQQQQQQQLSSHLHHHQHPLSSMHHHHPITSSHSYPSSLSQNSSRSMSPIPMETNSSSPQSPDIYKIRRLDMTDEERRKKKRREKKRRKDKE
Length515
PositionHead
OrganismSchistosoma curassoni
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Trematoda> Digenea> Strigeidida> Schistosomatoidea> Schistosomatidae> Schistosoma.
Aromaticity0.04
Grand average of hydropathy-0.692
Instability index70.89
Isoelectric point9.82
Molecular weight55551.19
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08456
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     622.04|      97|      97|     171|     267|       1
---------------------------------------------------------------------------
    7-   89 (99.96/29.76)	.......FSA..ANGTGSNLQA......GNTASATWINKLK..IVGRGqnwAVAP........CEPFYLMGTEPPAPDAALT.GAKNLIEHYGLENAYQKFCGKRLREE
   90-  168 (94.20/27.65)	LNAflphLSG..NIDVPASVDESGL..MSLIERPPIRGKELRP.FAPS...QLDHAFRLHP.........GPLPQEYASLFA.AAPSK.......HIHRSVQ.....DQ
  169-  264 (147.44/47.18)	.QQ....LSG..SNGTGTRVPATAV..PGLSSSGSFHRRRRRHEVHRG...ALASGSDSSSSIGVPGVGGGNVSASPASFFT.GPPTAYPQLGTVHTTTSLSSKPMLSQ
  265-  339 (102.67/30.76)	SHT....LSS..SLSITTSAPSTNVtmPNQSSTAS..........DNN...PVTQMVNHSKLVDHPP.GLIPVSA.PHSHL..........LGSSISTSSTSSEP...P
  340-  402 (68.15/18.10)	PPP....LLApiHHHSNQKLPHS.I..QNTSST.............LN...PLYNSNTSDASL.TP...SKSVPPAPPVLHSiHPPSINP...................
  404-  478 (109.64/33.31)	................NSSVPSQ....P..PSSHQFYHHHHRHQQQQQ...QQLSSHLHHHQHPLSSMHHHHPITSSHSY.....PSSLSQ....NSSRSMSPIPMETN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08456 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HIHRSVQDQQQLSGSNGTGTRVPATAVPGLSSSGSFHRRRRRHEVHRGALASGSDSSSSIGVPGVG
2) NVSASPASFFTGPPTAYPQLGTVHTTTSLSSKPMLSQSHTLSSSLSITTSAPSTNVTMPNQSSTASDNNPVTQMVNHSKLVDHPPGLIPVSAPHSHLLGSSISTSSTSSEPPPPPLLAPIHHHSNQKLPHSIQNTSSTLNPLYNSNTSDASLTPSKSVPPAPPVLHSIHPPSINPINSSVPSQPPSSHQFYHHHHRHQQQQQQQLSSHLHHHQHPLSSMHHHHPITSSHSYPSSLSQNSSRSMSPIPMETNSSSPQSPDIYKIRRLDMTDEERRKKKRREKKRRKDKE
160
228
225
515










Molecular Recognition Features






MoRF SequenceStartStop




1) FYHHH
2) PQSPDIYKIRRLDMTDEERRKKKRREKKRRK
417
482
421
512