<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08450

Description Uncharacterized protein
SequenceMHDISKCSDNLNFLDLLATVRADQIHSGSNNTRTGPYLIRYSTFLNHLQRIAIHCGLQLSSGPCSGGGTSAGALVWRLTSECFAVVVAATNNSITTSDSTYNNSPELTDLISIAAVYFEFNHDKAVPCPELATDLSMGKYSSLLQHVDNLLTIYAVPGDKIDRARTYLCLQALEKDLSMLTQAMRTDLENNIDAISTFRRAPNQKHDVFSMRDLVNRSLVGHFVGRTGGRLARLTYLVTSAQAMISNATGVIKNNLQMNSKSTYSSSIGCGSRDGLIGGYMARIGLCPRLSYVEDTSAVAQSTVQRLPFMPLVTLQKDAYGISVPHFAQPDEIKCISIEAEFVLHLDPPLPISTDAIQQLERTTGLSNTEIIDQKEEDIVLLILRKYKQEHLYGINTHLQNPNITQHSYQIKSDVKAYLVSSVPFTCSDQIGEIISILRKQASALAFYETFIVHPDKPVEKDDALTFSFNIKIMGGQMISLEFDDPNRLGAKIHASLHVRPFDVQCLELNYFSNTHDRLNSNCPSNDKEVDVMQLNKLDIESGGNLKANFSKILTKTHTLPIGFVWLLTQLQCPVHKQLVSLKLPVTNSYNSTENKESYSSVSQNQLTSLRTMLNRVKSSIIIRGANGTGGVLCGGDRKVSLDFESSSSFAAAQVFALNTPNYLNNAKKIPPLPPGVMATPPPAFTHLDTSSSDLGIISSLRPVNSQGKLRDMHPNSSLPAVSTNPSRGLRLDDLLVDSTFQTQQQLQQRNPPPISFSHSLPSYVSPIPGTHTTSLADVKEAYSDMINPNISTSNYLSLPTIHSSHKYGSSVLSGSNSIPSNLYNIPSMSVSASNSEATSSSAVVKSKSFTASPVSDNSRAPSTSGSMLVNLLNEDSLSTSIPLVSPSSMTDRHHYNPSHSLTNLQNSPLTSAASSINVSNSRLPGLMLSNSSQLPSSDAQLPQGCGKPLSSSATNLTPNSSQYPSVRNSSLITPNTGRTKHTSLKNSQASLTVNPTSNPKKPRKRRRGTVEGSFRCISSQKGNTPVPGVYSNYPTTKHQRVDTVLPTTSISLSGTYQRPTFNQTNSNFSSCSLPYVQQSTAASTVQSINMQIPNPSKSVYDFDDNPSSMFDVPVGNISSSNSLSFSSGSSLTSPKSGVSVNPLQSGSLAVSNTNPISNFPVTTMMSSNSNLERTIERKTSLKMTIKTIPSQPITSTPKARVNFNQNEVDKYNKLQSVQSNSTPINTSDSGGTVHPAQPLPSVKKRKKRSVEGKPSAYMLQMLQLANCSISGSDASVTTTSVTTGASGVPSQSAITPLVLNSSGLKQIKSTNKLVGHGSVLVKKERKRRLGHGFTEKTHFSFIPNSNTYNQAQETADNSNIPKLIKINRVSRPPTSDVPRDNQTGSGTTPNLYSNCISMSPNSSSKKKVSALNSTPLGTGAGTSSGSDDMMVAKRLFSSSASPLVSGDKRKRNPETSKQSNNSQSAHPNSGTSSDSAFISSPLLPCTSSDPPTNSNTSRKTPRPSLHTAPNLPRVPHTPTSKSQPVQQSSTLNYLSSSSVCTPNPASVSVVGSSSGLIKGYKIPKKKSTTTGCLPSVSLSDASGDKSIGMLSTTLQQIQESVSSYRDTPDSQSPEKSDESSLTIVENMYPSSNDPNLEGVDPINAVVYNANINDAANNTDDNSSIPSDSVSGFTAPNTESCSQSILHPISLQSNSSVSGQCSQSSQQQFPRKSSVKSISDIVDKLRAKSTTSITSSTSTIISDSSNVGSSDTTAITSYEVKDSTINSMLSDNPSCVRSITKKNDEFQDQWRDNIFEKFCPSGTPTPHQTENGQNNICRSDSEVDLSTSIENSEESVWTSGNKEPVYDKDERNISSSNLNASMIHSNTQSISDSEGKQGKQQFEVCCLVLQ
Length1890
PositionMiddle
OrganismSchistosoma curassoni
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Trematoda> Digenea> Strigeidida> Schistosomatoidea> Schistosomatidae> Schistosoma.
Aromaticity0.05
Grand average of hydropathy-0.448
Instability index47.73
Isoelectric point8.76
Molecular weight203582.91
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08450
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            12|     677.01|      71|      71|     811|     881|       1
---------------------------------------------------------------------------
  523-  624 (39.53/ 8.62)	CP......SND.....KEVD......V.MQLNKLDI..........ESG.........gnlkanfsKI...LTKTHTL.PigfvwlltqlqcpvhkqlvslklpvTNSY.N...........ST..................ENKES.....Y...S..SVSQNQLT.SLRTmlNRV.KSSiiIR
  625-  718 (50.66/13.25)	GA......NGT.....GGVLcggdrkV.SLDFESSS..........SFA.......aaqvfalntpNY...LNNAKKI.P......................plpPGVM.ATPppaftHLDTSS..................SDLGI.....I...S..SLRPVNSQ.G.KL..RDM.HPN..SS
  719-  790 (49.04/12.58)	LP......AVStnpsrGLRL......D.DLLVDSTF..........QTQ.........qqlqqrnpPP...ISFSHSL.P.........................SYVS.PIP.....G..........................TH.....T...T..SLADVK.E.AYS...DMI.NPN....
  791-  860 (69.30/21.01)	.I......STS.....NYL.............................S.....lptihsshkygsSV...LSGSNSI.P.........................SNLY.NIP.....SMSVSA..................SNSEA.....T...S..SSAVVKSK.SFTA..SPV.SDN..SR
  861-  934 (77.86/24.57)	AP......STS.....GSML......V.NLLNEDSL..........STS...................iplVSPSSMT.D.........................RHHY.N.P.....SHSLTN.................lQNSPL.....T...SaaSSINVSNS.RLPG..LML.SNS..SQ
  935- 1001 (65.35/19.36)	LP......S.S.....DAQL......P.QGCGK.PL..........SS........................SATNLT.P........................nSSQYpSVR.....NSSLIT..................PNTGR.....T...K..HTSLKNSQaSLTV..NPT.S.N..PK
 1002- 1092 (51.37/13.55)	KPrkrrrgTVE.....GSF.........RCISSQKG..........NTPvpgvysnypttkhqrvdTV...LPTTSIS.L.........................SGTY.QRP.....TFN..Q..................TNSNF.....S...S..CSLPYVQQ.STAA..STVqSIN..MQ
 1093- 1141 (58.03/16.32)	IP......NPS.....KS...........VYDFDD...........................................nP.........................SSMF.DVP.....VGNISS..................SNSLS.....F...S..SGS......SLT...SPK.SGV..SV
 1142- 1199 (54.28/14.76)	NP......LQS.....GSLA......V.SNTNPIS...........................................................................NFP...vtTMMSSN..................SNLER.....TierK..TSLKMTIK.TIPS..QPI.TST..PK
 1200- 1288 (39.38/ 8.56)	AR........................V.N.FNQNEVdkynklqsvqSNS.............tpinTS...DSGGTVH.P.........................AQ...PLP.....SVKKRKkrsvegkpsaymlqmlqlANCSI.....S...G..SDASVTTT.SVT.......TGA..SG
 1423- 1474 (57.94/16.28)	TS......SGS.....DDMM......VaKRLFSSSA..........S................................P...............................LV.....SGDKRK..................RNPE.............TS.KQSNN.SQSA..HPN.SGT..SS
 1484- 1539 (64.27/18.91)	LP......CTS........................................................S...DPPTNSN.T.........................SRKT.PRP.....SLHTA...................PNLPRvphtpT...S..KSQPVQ.Q.SSTL..NYL..SS..SS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     444.38|     129|     201|    1549|    1681|       2
---------------------------------------------------------------------------
 1550- 1681 (212.59/113.39)	VVGSS.SGLIKGYKIpkKKSTTTGCLPSVSLSD.ASGDKSI.GMLSTTLQ.QIQESV.........SSYRDTPDSQSP.EKSD.ESSL.T.IVENMYPSS.NDPNLEGV.DPINAVVYNANINdAANNTDDNSSIPSDSVSGFTAPNTESC
 1683- 1745 (67.81/27.06)	......................QSILHPISLQS.NS...SVsGQCSQSSQ.Q.......................QFP.RKSS.VKSI.SdIVDKLRAKS........................TTSITSSTSTIISDS.S..........
 1746- 1885 (163.98/76.35)	NVGSSdTTAITSYEV..KDSTINSML.....SDnPSCVRSI.TKKNDEFQdQWRDNIfekfcpsgtPTPHQTENGQNNiCRSDsEVDLsT.SIENSEESVwTSGNKEPVyDKDERNISSSNLN..ASMIHSNTQSISDSEGKQGKQQFEVC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08450 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVSNTNPISNFPVTTMMSSNSNLERTIERKTSLKMTIKTIPSQPITSTPKARVNFNQNEVDKYNKLQSVQSNSTPINTSDSGGTVHPAQPLPSVKKRKKRSVEGKPS
2) GDKSIGMLSTTLQQIQESVSSYRDTPDSQSPEKSDESSLTIVENMYPSSNDPNLEGVDPIN
3) PVPGVYSNYPTTKHQRVDTVLPTTSISLSGTYQRP
4) SFIPNSNTYNQAQETADNSNIPKLIKINRVSRPPTSDVPRDNQTGSGTTPNLYSNCISMS
5) SIENSEESVWTSGNKEPVYDKDERNISSSNLNASMIHSNTQSISDSE
6) SIPLVSPSSMTDRHHYNPSHSLTNLQNSPLTSAASSINVSNSRLPGLMLSNSSQLPSSDAQLPQGCGKPLSSSATNLTPNSSQYPSVRNSSLITPNTGRTKHTSLKNSQASLTVNPTSNPKKPRKRRRGTVEGSFRCIS
7) SSSKKKVSALNSTPLGTGAGTSSGSDDMMVAKRLFSSSASPLVSGDKRKRNPETSKQSNNSQSAHPNSGTSSDSAFISSPLLPCTSSDPPTNSNTSRKTPRPSLHTAPNLPRVPHTPTSKSQPVQQSSTLNYLSSSS
1150
1584
1026
1341
1828
881
1403
1256
1644
1060
1400
1874
1019
1539










Molecular Recognition Features






MoRF SequenceStartStop




1) KKRKKR
2) LIKGYKIPKKK
1244
1557
1249
1567