<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08449

Description Uncharacterized protein
SequenceMLPTWMADRLTELQDAINLQAENLCNAIGVIQQVAQPSFFSDFNWASRSAKPEYQAFIQAQPTDDIPQNALTDSLFLLALDIARSFAVAISATAKQLDALIGALPEEEASADIQRATVHKLLEAYRSEGAKLARITTKLESRLAEVRRCLTAIAQTQLTTQSLESEVLFIYHFNRCIENFMETNPNLSLNNDSSYEAPEYIYSSPPSSISWLTYLTIIFLFILFFRLCFTFGIVDRLHALVNFILAISTPSGRKRRALRAKCVEDLGNLRTQLKSVHMVDEFATYSKLERKIKLLERQLNSLAPETLVGSMVRQVSIYVGLYVIEAIFMAYLISYSPIETISPVTLQSLMINNHSMKDITIFICQVISYIPVKILVICWIILCRLTIGPAVAKLGNTLQRQQQSQNQQSNQNSSVNFTNSTTTTVPTTSVPNTSS
Length435
PositionMiddle
OrganismSchistosoma curassoni
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Trematoda> Digenea> Strigeidida> Schistosomatoidea> Schistosomatidae> Schistosoma.
Aromaticity0.09
Grand average of hydropathy0.107
Instability index45.66
Isoelectric point6.55
Molecular weight48772.65
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 

Receptor for GET3/TRC40-mediated insertion of tail-anchored
(TA) proteins into the ER membrane. 


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
GO - Biological Process
tail-anchored membrane protein insertion into ER membrane	GO:0071816	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08449
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     186.85|      64|     154|      86|     158|       2
---------------------------------------------------------------------------
   86-  158 (88.36/89.82)	FAVAISA.TAKQLDALIGALPEEEASADIQRATVHkLLEAYRSegaklariTTKLESRLAEVRRCLTAIAQTQL
  243-  307 (98.49/75.84)	FILAISTpSGRKRRALRAKCVEDLGNLRTQLKSVH.MVDEFAT........YSKLERKIKLLERQLNSLAPETL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.66|      13|      31|     327|     339|       3
---------------------------------------------------------------------------
  327-  339 (24.65/15.77)	IFMAYLISYSPIE
  361-  373 (25.01/16.09)	IFICQVISYIPVK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08449 with Med21 domain of Kingdom Metazoa
Unable to open file!