<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08397

Description Uncharacterized protein
SequenceMIDYQFKEELIKTRERVEDLYSFEGFKVGRGTYGHVYKAQPRHPEQSSENGAKEFALKLIEGQGFSMSACREIALLRELKHPNLIKLQRVFLTTDRKVWLLFDYAEHDLWHIIKFHRAAKQKKQPVLVPKGMVKSLLYQILDGIHYLHSNWILHRDLKPANILVMGEGPGVERGRVKIGDMGFARIFHNPLKPLAELDPVVVTFWYRAPELLLGAKHYTKAIDIWAIGCIFAELLTSEPVFFCREEDIKASSPYHQDQLNRIFTVMGYPSESDWQDLKKMPEYQKLTQDFKRANYANCTLQRYMDKHKIKADTRSFSLLQRLLTMDPIKRVTAQDAMDDPYFKEDPRPTTDVFSGCDIPYPKREFLSDENDDKSASASKPQQVQAPQQSQQQPIGMHPQQSVMEPAAKKIRMQQGPQMPATQQMEPIMNVPTSGMFATSGTQDYPPVGSGPAISNKGGIPFEQHSQQMIQSQHINSGMQQMPYGHQQQHQVMNQGPNMYQQQQIGINQQLGGPAQGQMAQRPVQMSTQSSVMQSSYQQQMVQSGMISSQQMMNSGSGILGQQGGIAGPGPMGGPQNQMGPPQGQMGPQGPTIMQQMRSQMSYVDQNGRVIQGGIIMQPSQEMMQQQGPYMIQQQQWSQIQPRY
Length643
PositionKinase
OrganismOnchocerca flexuosa
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Onchocerca.
Aromaticity0.08
Grand average of hydropathy-0.641
Instability index56.50
Isoelectric point8.76
Molecular weight73009.70
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08397
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     341.26|      72|      75|     453|     526|       1
---------------------------------------------------------------------------
  381-  448 (70.82/19.68)	.............QQVQAPQQS....QQQ.PIGmH...PQQ.SVMEpaakkirmqQGPQMPATQQ..MEPIMNVPTSGMFA.TsgtqdyPPV.........G
  453-  526 (136.83/49.21)	ISNKGGIpFEQHSQQMIQSQHINSgMQQM.PYG.H...QQQHQVMN.........QGPNMYQQQQIGINQQLGGPAQGQMA.Q......RPV.......QMS
  531-  601 (91.70/27.53)	VMQ......SSYQQQMVQSGMISS..QQMmNSG.SgilGQQGGIAG.........PGPMGGPQNQMG.......PPQGQMGpQ......GPTimqqmrsQMS
  610-  635 (41.92/ 9.17)	I..QGGI.IMQPSQEM.........MQQ...........................QGPYMIQQQQ.....................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.92|      29|      35|     280|     314|       2
---------------------------------------------------------------------------
  298-  330 (34.42/35.52)	CTLQRYMDKHKIKADTR.........sFSlLQR..lLTM..DpIKR
  331-  374 (35.51/17.82)	VTAQDAMDDPYFKEDPRpttdvfsgcdIP.YPKrefLSDenD.DKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     136.43|      32|      71|     115|     146|       5
---------------------------------------------------------------------------
  115-  146 (53.75/34.70)	FHRAAKQKKQPVLVPKGMVKSLLYQ....ILDGIHY
  153-  180 (39.06/23.10)	LHRDLKPANILVMGEGPGVERGRVK....IGD....
  187-  218 (43.62/26.70)	FHNPLK....PLAELDPVVVTFWYRapelLLGAKHY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.18|      23|      31|     230|     256|       6
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  230-  256 (34.13/30.69)	IFAEL.LTSEPVFfcreEDIKASSPYHQ
  262-  285 (39.05/23.18)	IFTVMgYPSESDW....QDLKKMPEYQK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08397 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QSGMISSQQMMNSGSGILGQQGGIAGPGPMGGPQNQMGPPQGQMGPQGPTIMQQMRSQMSYV
2) VFSGCDIPYPKREFLSDENDDKSASASKPQQVQAPQQSQQQPIGMHPQQSVMEPAAKKIRMQQGPQMPATQQMEPIMNVPTSGMFATSGTQDYPPVGSGPAISNKGGIPFEQHSQQMIQSQHINSGMQQMPYGHQQQHQVMNQGPNMYQQQQIGINQQLGGPAQGQMAQRPVQMSTQSSVMQSSYQQQM
542
352
603
540










Molecular Recognition Features






MoRF SequenceStartStop




NANANA