<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08378
Description |
Mediator of RNA polymerase II transcription subunit 13 |
Sequence | MKHVCRACHVMPGTSEVPGVLSACLVSLEPEAHLRVFPSSFQHDDRFLKNSRYRTLTTPDDTSCTHILVFPTSPELNLDHQGGNGVAELEEDDFSNLLTEEIGEEFSELIGNGEDLMTNGTGPPQQSTNFRLGGNTGIPSDYADVSIENQPLATGYYISTAPASDLPEWFWSACPSAKRRNPVHLKSSLHLNTPNVQQGDDISSFGKGTEACHHQLDSQATADVLRYVLEMYNALSWLNIDLISGERRSCLPIHIQALMWLCNAVNRFIN |
Length | 270 |
Position | Middle |
Organism | Onchocerca flexuosa |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida>
Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Onchocerca.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.336 |
Instability index | 62.96 |
Isoelectric point | 4.89 |
Molecular weight | 29842.99 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364134
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP08378
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 284.19| 86| 139| 30| 117| 1
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30- 117 (147.92/99.29) PEAHLRVFPSSFQHDDRFLKNSRYrtLTTPDDTSCTHILVFPTSPEL...NLDHQGGNGVAE..LE.EDDFSNLLTEEI.GEEFSELIGNGEDLM
167- 259 (136.27/85.71) PEWFWSACPSAKRRNPVHLKSSLH..LNTPNVQQGDDISSFGKGTEAchhQLDSQATADVLRyvLEmYNALSWLNIDLIsGERRSCLPIHIQALM
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