<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08297

Description Uncharacterized protein
SequenceMDISPRGDEDELWDINLSCKPFIKSLALKHTDMVRCAIENNSPSQVCTKCVEQYIHFREQQYRSLHLVNTTSLDNRTCTAVIYNCLQINWDFEHGNSSHTFDKKTVQFKEYLKKLRHCVVRLNESSPGQICQSCQKDYETLFGFYWKIFSDPNTFFCIDVDSEMNDTMKLWQVLIFSVSVLAIVIVLFYAGSYIQSEQTNSNLIHYSRMQEAQPVGSRSRILSSSTLDSSYQHPPQKQMTGEDGQDGGIRQQHGISAAQQPGVPSNTGAHLLKNSLATPLASLPAAPPQCGPPTVSLALLIDFAIHWNYRQFEILSELNSKKKETDRKISVVEFAHNTRLIFVRLLAIVRWLKSAKKFEPLASIRHLLDEQATRYVESADRLVEIARNELPNARLPAFQVAQAVDVLTLGSYPRLPQNIKERFIPPASLSAAERRLTLRRLNQLIEFHLAQQAAQLSPRIRQIAVRNGMAILMVPGEFEMALTRLGDDPATRWMLLNIRILVESAEAYKRRTAKLDDSVQILDDNDVQMVEESDRKGVDKTENGAAVPAASEGVRAPIAPVQGVLIDQSFRETYQNRNRTWNSVFEQHRHDAQPSSFFSRASHRAAAISGPNMRPDLGEEVIVRPSGRAPPLPMVVQPNQNDESRPANSQHRKVLQSIFRPPVELMFQGDWDQALQAARQKGVWLLVNVQEASEFACAVLNRDIWSAETVREVYHDSADGARIRGYYGLTSFPAIFIVDPRTGEEVSGRLKASEPVSFLDSWVSGRARVVQLLLRLPDGRGERVRMWMAAPLSALFSLLLSMGVAPIDHQLVLDYPRREYSLTQQNRRLSLDSAGFGVQEVVHVDRIKP
Length849
PositionTail
OrganismGlobodera pallida (Potato cyst nematode)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Tylenchomorpha> Tylenchoidea> Heteroderidae> Heteroderinae> Globodera.
Aromaticity0.08
Grand average of hydropathy-0.326
Instability index47.57
Isoelectric point7.93
Molecular weight95945.13
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08297
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     193.54|      50|     219|     365|     416|       1
---------------------------------------------------------------------------
  314-  363 (38.44/20.70)	..ILSELNSKKKET.DRkisVVEFAHNtRLIFVRL.L...AIvrWLKSAKKFEPLAS.....
  365-  416 (73.48/58.24)	RhLLDEQATRYVESADR...LVEIARN.ELPNARL.P...AF..QVAQAVDVLTLGSyPRLP
  421-  461 (43.10/24.51)	........ERFIPPAS.....LSAAER.RLTLRRL.NqliEF..HLAQQAAQLS....PRIR
  484-  527 (38.53/21.06)	R.LGDDPATRWMLLNIR..iLVESAEAyKRRTAKLdD...SV..QILDDNDV..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.17|      43|      87|       7|      54|       2
---------------------------------------------------------------------------
    7-   54 (66.14/60.11)	GDEDELWD.INLSCKPFIKSlaLKHTdMVRcaIENNSPSQVCTKCVEQY
   95-  138 (75.03/49.02)	GNSSHTFDkKTVQFKEYLKK..LRHC.VVR..LNESSPGQICQSCQKDY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08297 with Med14 domain of Kingdom Metazoa
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