<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08284

Description DNA ligase
SequenceMATIEEVIELTKWRDGQKIPYLALAKTLERIEATSSRLENIRILSDFFRRRHLHLSVRLEPRAGATGRTVDMIKKELKTKGDLGIVAQQSRSNQRMLSKPPPLTVPHVFNRLREIAKMAGISSMDKKVKAIQALLVPCVECEARYLVRCLQGKLRIGLAEQSLVVALANAFTTMELRTQKKKLSGEKLKERMAEDVQKLKTVYCECPNLGRIIEVVLRSGIASLADECRLTPGIPLKPMLAHPTKGIQELLDRFGTAEFACEWKYDGERCQIHLLSDGTVKIFSRSQEDHTGKFPDVVRRIPAALNRKVQDFVVDGEVVAWEPKQKQILPFQILSTRKRKNVGDDVEVQVIVFLFDLLFIDGQSMTGETYRTRRQRLRKAFTEVPGSVVFANSLDTQDTEEIQMFMDDAIRGNCEGLMVKCLDENATYEISKRSRNWLKLKKDYLEGVGDTLDLVVIGGYCGTGKRTGVYGGYLLACYNPETEQYESIAKVGTGFKEEDLKNQHKELQELRIDKPRSYYAFDPSIAPDHWFKPALVWEVKAADMSISPRHLAARGLVDKERGISLRFPRFIRNRPDKKPEDATSGEQIAEMYRNQDHIKNQKNGNAADEEKEFHSPTATALDFSRGVPSSVPSGAFHPHHFVGSTSNPCAQQLSGTATFLHLGQQLPSSINPSAGQFLLHQQQFQHLQQQQQLRQETAEEAKRRFEIECEFVQALANPHYLNYLAQRGYFKEEYFVNYLKYLLYFKRPEYARTLKFPQCLFFLEALQSADFREAIASVDNARYIEDQQLLQWHFYIRVRQRLLENTQPL
Length809
PositionMiddle
OrganismGlobodera pallida (Potato cyst nematode)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Tylenchomorpha> Tylenchoidea> Heteroderidae> Heteroderinae> Globodera.
Aromaticity0.09
Grand average of hydropathy-0.459
Instability index46.36
Isoelectric point8.87
Molecular weight92599.09
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
DNA binding	GO:0003677	IEA:InterPro
DNA ligase (ATP) activity	GO:0003910	IEA:UniProtKB-EC
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
DNA biosynthetic process	GO:0071897	IEA:InterPro
DNA recombination	GO:0006310	IEA:UniProtKB-KW
DNA repair	GO:0006281	IEA:UniProtKB-KW
DNA replication	GO:0006260	IEA:UniProtKB-KW
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08284
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.06|      22|      38|     615|     636|       1
---------------------------------------------------------------------------
  615-  636 (41.92/27.10)	SPTATALDFSRGVPSSV.PS.GAF
  654-  677 (34.14/20.76)	SGTATFLHLGQQLPSSInPSaGQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.66|      35|      94|     155|     211|       2
---------------------------------------------------------------------------
  117-  159 (49.04/55.42)	KMAGISSMDKKVKAIQALlvPCVECEARYLVRclqgklRIGLA
  182-  222 (54.62/23.21)	KLSGEKLKERMAEDVQKL..KTVYCECPNLGRiievvlRSGIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.44|      15|      37|     710|     724|       4
---------------------------------------------------------------------------
  710-  724 (28.40/18.65)	EFVQALANPHYLNYL
  734-  742 (17.23/ 8.39)	YFVN......YLKYL
  749-  763 (26.81/17.19)	EYARTLKFPQCLFFL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08284 with Med31 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PRFIRNRPDKKPEDATSGEQIAEMYRNQDHIKNQKNGNAADEEKEFHSPTATALDFS
568
624










Molecular Recognition Features






MoRF SequenceStartStop




NANANA