<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08282

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMEQQQQAIAAASGISSGFLRTKISLKGSQSQLSLVSPFYGMKPELPSQSQLLGSDDLISLFDLSGAYNRYCGAKKPREDLASFLPHVCAATHINKKADSQCSLRKLIEDPPIMGREINNLTASQMVGFKLTPGPIPDANRFFDLPEQPTNSGGATTAFLPHSASAPQFEPSTVVDDRRQRKRIKRSLDELTLEDADRKAKRAKGGEESGGREKERKKKKEKKRKKKDKEKRVEEETVKRIGGEPIKRETPEQPTNSGGATAAFLPHSASAPQFEPSTVVDDRRQRKRIKRSLDELTLEDADRKAKRARGGEESGGREKERKKKKEKKRKKKDKEKRVEEETVKRIGGEPIKRETVMPFF
Length359
PositionHead
OrganismGlobodera pallida (Potato cyst nematode)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Tylenchomorpha> Tylenchoidea> Heteroderidae> Heteroderinae> Globodera.
Aromaticity0.04
Grand average of hydropathy-1.072
Instability index61.12
Isoelectric point9.84
Molecular weight40250.31
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08282
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|      86.72|      10|      15|     194|     203|       1
---------------------------------------------------------------------------
  175-  184 (18.15/ 8.50)	DDRRQRKRIK
  194-  203 (17.74/ 8.12)	DADRKAKRAK
  212-  221 (16.19/ 6.72)	EKERKKKKEK
  280-  289 (18.15/ 8.50)	DDRRQRKRIK
  299-  308 (16.49/ 6.99)	DADRKAKRAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     264.28|      74|     104|     145|     248|       2
---------------------------------------------------------------------------
  145-  248 (131.99/67.12)	PEQPTNSGGATTAFLPHSASAPQFEPSTVVddrrqrkrikRSLDELTLEdadrkakrakGGEESGGRekerkkkkekKRKKKDKEKRVEEETVKRIGGEPIKRE
  250-  353 (132.30/67.29)	PEQPTNSGGATAAFLPHSASAPQFEPSTVVddrrqrkrikRSLDELTLEdadrkakrarGGEESGGRekerkkkkekKRKKKDKEKRVEEETVKRIGGEPIKRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.60|      16|      22|      18|      38|       3
---------------------------------------------------------------------------
   22-   38 (24.30/28.58)	KISLKgSQSQL....SLVSPF
   42-   61 (24.30/10.20)	KPELP.SQSQLlgsdDLISLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.43|      19|      22|      93|     111|       4
---------------------------------------------------------------------------
   93-  111 (34.43/19.39)	INKKADSQCSLRKLIEDP.P
  117-  136 (31.00/16.87)	INNLTASQMVGFKLTPGPiP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08282 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DANRFFDLPEQPTNSGGATTAFLPHSASAPQFEPSTVVDDRRQRKRIKRSLDELTLEDADRKAKRAKGGEESGGREKERKKKKEKKRKKKDKEKRVEEETVKRIGGEPIKRETPEQPTNSGGATAAFLPHSASAPQFEPSTVVDDRRQRKRIKRSLDELTLEDADRKAKRARGGEESGGREKERKKKKEKKRKKKDKEKRVEEETVKRIGGEPIKRETVMPFF
137
359










Molecular Recognition Features






MoRF SequenceStartStop




1) DELTLEDADRK
2) ESGGREKERKKKKEKKRKKK
3) REKERKKKKEKKR
293
312
211
303
331
223