<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08271

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMSSEKSKNADMAHVSLFPSPPWQLVNRHQTGPGASQEPPIRPPTPPGQTVYRMFGNLYNLDDAILRSLESQGVRRVYPQVDFAVISLLLMSSNIVCCIFSIVPLPNQTYNRKRELRKINFSILANYLDLLDIITRDPSSPKRTERLDNLAILFINMHHLVNEYRQHQARDLLREILSYQVSIASQTVEKAELYTTRANDLLRNAGQELIVPGQPSVTFNVPGVSTNCVDTVRSGLVELGPTLAPLLQTVLDETMGGDPACRRIQAAPGLGSSSRLPGNLLDHPGSQSSLDCFNSDGILDGVCGDDPADHVDPSLWQFLSECQLDDGASYPDHCPG
Length335
PositionMiddle
OrganismEchinostoma caproni
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Trematoda> Digenea> Plagiorchiida> Echinostomata> Echinostomatoidea> Echinostomatidae> Echinostoma.
Aromaticity0.06
Grand average of hydropathy-0.261
Instability index53.94
Isoelectric point5.24
Molecular weight36899.36
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. 


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08271
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.44|      10|      27|      18|      27|       1
---------------------------------------------------------------------------
   18-   27 (22.61/12.23)	PSPPWQLVNR
   43-   52 (21.82/11.57)	PTPPGQTVYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.28|      13|      27|     162|     174|       2
---------------------------------------------------------------------------
  162-  174 (23.71/19.25)	EYRQHQARDLLRE
  191-  203 (22.56/17.97)	ELYTTRANDLLRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.12|      21|      22|     275|     295|       3
---------------------------------------------------------------------------
  275-  295 (40.16/22.95)	LPGNLLDHPGSQ..SSLDCFNSD
  298-  320 (36.96/20.59)	LDGVCGDDPADHvdPSLWQFLSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.23|      12|      27|     112|     123|       4
---------------------------------------------------------------------------
  112-  123 (20.35/15.03)	KRELRKINFSIL
  141-  152 (19.88/14.53)	KRTERLDNLAIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08271 with Med7 domain of Kingdom Metazoa
Unable to open file!