<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08266

Description Uncharacterized protein
SequenceMSEDFVRDGYKYIKPVRDEYQSCREESRFINIDSLLNFFRGVVANKRENTSFQDSKKKQIPNLRDTVVPVIDIHKEHVSDWFRELAGSVPLQSLGRRVLYYKDKDKDEILSELLSNKVPTTRAIWFINMSVIVSAALAENAKKKPRALSDPTVEWTTALCGMLTRILDQISCESSNDALDSDWNYLFTLLLAMYDMDMADHWEVLIWLVDRAESISKPFRPPAPYATPPTQPSLQLQESIENERLKLKFFLHYLLRVGIRFTESELITRRLLYWCCSVLSEVTYCDSRSPGNEPRSSAQLVLDEYIETCTCPLHRVIVMSLSSLIVCLTMSCPSAAVWNDIPPVGDHFYLRGSPLDLIPYSLVALPMPRGPEVIPIRKCLTELEEIIITRGRLAELGWNRQAATNVNGEQVERSLKLLNILDSQNYYVAKELNPMEALFNLIFKDETLHVDTGALVTTLCDWAVSTHRFGIHRAIIVACLLEQLWCTFQSNTTSRQLFQDTLVAFLDNFSTTLPPFVGDQAPIDNEPMKSLVCLFGELIDRQLFDHDAYVRHFIARGAFNTSDHPLAFETGSIHHQLGSSTASLGANTPNAHSRATHVPSCLTNLNLSNNATAQHSVASEMSEENDRCSMDNPDSVRSELGFQPCAPPTHGSHANNPEKPVQFGSTVTRSPHLHFLTQFPIPQGECYAHEQNQRYQLLYGSVRARDRARSRVRHLVRDIKKLFTKGSYLVDVVQGEMGKRKKTKDREKDREQSVSASGGGAGGSGNSASGGGTATTGSLSSTGHRSSEDTHSIDRLHEDIMSRFVRLSYHDMECVISQCTPTFMKMLNGSSGGSTSNLTSDEHSASFGLNNPPSPQVNSSTMGNTMIALPGSSGSYTSLAPPTASQTHIYMPVPSSIFLFFDLIETSLNITCLISTVVDTLERLKSLFENRTQFMTLYMSYMCLRAIGILQRYQPVLLTMSIAPRLFSTLIAQVFQVKESTQCFPSERCILAYVHGLFSSSCAVRSSFTSFYGKAHGKVSAIFRRVLPGNGKGKFDPNYAAELLDEKSQDNGASFPTYAEDLRRESNSRFSFVCRAIVFVCQAETSERLNYLCSLCVELTAQCSELSSEWIGSLYAILAPRTEAPRYEPLVSTIEPTDVNMYDNLSSLIGTLLSRHCFPISDFLQSVICAAMAHGLNQVSQPIGPQLEPIIRLACHILHRLFTAESTVSSLQTASNVLTPNHDVSVSNASNANPDSMVSSPPFRISEPLLLTGALQKVGTEVLVDVLKMLMVNYDKAFHADPSHSDDHIDSTGEPPDDDGDGNQGRGSDLDMDDDQDSTEDSSDPSRRRKRGKQNESSKARQRKRRRVSVRRAQTSVHPVHFIVQRYLDSGTLPTVAELRSLPLDGLIQLVLREICTVYWVRERFCGMPYERLICENVLIDKNFSHSQARRLLHTIFYPYDTSWSDVASASDGLAEAMCHALSNLNLWTFNCAHMKFELLYKQIPFSHQAEVLGFVAQCLVSEFQRQALTWLNADGSCVTTDGSVGLIGGLPNFDLDEDDPVWLLPVLIQKLPKPMKCQIVKITLEASTDVQPACPDWTTYDNLKGIRNYWKHKNDEDKESVLLQHSIILAHPAFFSLLQICLEEADHKEALNEQIEYFVPNARDTEDHVPDNLRTRQVVQECLRLRLTLIGQRFQELLTDSETCTRLAQLLTQLISHGVTEPESNSALFFMVLDMLQTLVHTFAARNGLEGKPYQNLVKRLRRELSERPTTSGIEQIRPLLIPLKAAYTVFVTGRSRQRAGASGTAGNSSSGGSGTGSLGKAGGAGKSSGNKGSGKSSGGNRSGLFGSVGSGPGRGPKKRGFMIIGKERFAPWDIQDPSKQSALLCMHGATLTEAVLSRTEDQANRLIRHDHFIRLRRPLEFYLTPVYPEKNESKGSVHNGPPSTSKALKRESSNASSMLPPSLRPQSSNVPHCEPSPSALQASRKHGSVGHGMNKLPPRSFGHDGGVPEEPTAYSESIRIGSSIQQETLSRAGSMHSLQSEYSQDLSSEHLRAQSNPSSFGSALHVNMIKSQYVQPCIGSGSIDGHIQSVSEGSMKSMDTSKHGPRTAVLDDVYSELAFSQTEPTLSKPGRAPGKFAPDPPQIASGTADMSTSFVSAQPTATKRKRGAGRRAPVASVSERSLPGNATAARPAPNVAPGRTAAATVRAANAAANARMSSVGMMDTLHVHSTLPCGETVPDIASSSAPQNSWVNKSFPHDSVNPADGHMSAQSSRGPAHLVNLGGFIRNRTQQQQQQQQQQQLVSVSLHPHHQHQSQAYNTFADSGSNPAGTIRGSQQELCTATVYVQSNPSFDGSVGIPHSLGVAGPTTSYGDNTVSFVTSFPQTVDNVINPVRQQTGGTQNAPRYMPQLTTHRAQMTVHQSVPITGNQSQQLVPNPPPYPVSQSSHTHLTHHQQQQQTQHVIGRNPDDNFVLMLDTSTDDAFVRAGGQPGMPSHLIPRQTAYHTMRPHQPHLHAHHTQQQPHQHNAVGDQIPVQMMPQHTHGTGLGATFQRVPNPSQIHAPPHNAQTNPTQTHYSRFAY
Length2561
PositionKinase
OrganismEchinostoma caproni
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Trematoda> Digenea> Plagiorchiida> Echinostomata> Echinostomatoidea> Echinostomatidae> Echinostoma.
Aromaticity0.07
Grand average of hydropathy-0.383
Instability index53.84
Isoelectric point6.76
Molecular weight282681.41
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08266
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.29|      16|      16|    1027|    1042|       1
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 1011- 1026 (23.30/11.03)	F...YGKAHGKVSAIFRRV
 1027- 1042 (27.27/14.23)	L...PGNGKGKFDPNYAAE
 1043- 1061 (18.72/ 7.32)	LldeKSQDNGASFPTYAED
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     319.50|      60|      62|    2408|    2467|       2
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 2278- 2309 (40.47/15.61)	....................QQ...QQ..QL.........................VSVSL...HPHH.QHQSQAYNTFAD.SGSNP
 2310- 2355 (40.81/15.81)	AGTI...................rgSQ..QEL............CTA.....TVYVQSNPSfdgSVGI.PHSLGVAGPTTS.YGDN.
 2356- 2406 (39.98/15.33)	TVSFVTSFPQTVDN..................vinpvrqqtggtQNA.....PRY.MPQLT........THRAQMTVHQSVpI....
 2407- 2448 (71.62/33.83)	..................TGNQ...SQ..QLV............PNP.....PPYPVSQSS...HTHL.THHQQQQQTQHV.IGRNP
 2449- 2506 (74.86/35.73)	DDNFVLMLDTSTDDAFVRAGGQpgmPS..HLI............PRQ.....TAYHTMRPH...QPHLhAHHTQQQPHQH.......
 2511- 2558 (51.76/22.22)	DQIPVQMMPQHTHGTGLGA........tfQRV............PNPsqihaPPHN.AQTN...PTQ..THYSR.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     195.64|      47|      50|    2123|    2169|       4
---------------------------------------------------------------------------
 2058- 2079 (32.57/14.88)	........PCIGSG............SI...D.........................GHIQSVSEGSMKS
 2080- 2120 (41.53/21.44)	MDT.....SKHGPR............TAvldDVYSelAFSQTEPT.LSKPGRAPGKFAP...........
 2123- 2166 (68.23/40.98)	........PQIASG............TA...DMST..SFVSAQPT.ATKRKRGAGRRAPVASVSERSLPG
 2167- 2229 (53.32/30.07)	NATaarpaPNVAPGrtaaatvraanaAA...NARM..SSVGMMDTlHVHSTLPCGETVP..DIASSSAPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.40|      41|      45|     792|     836|       5
---------------------------------------------------------------------------
  796-  836 (75.99/49.62)	LHEDIMSRFVRLSYHDMECVISQCTPTFMKMLNGSSGGSTS
  838-  878 (73.40/38.96)	LTSDEHSASFGLNNPPSPQVNSSTMGNTMIALPGSSGSYTS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     177.28|      45|      45|     459|     503|       6
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  428-  456 (25.72/11.36)	..................VAKELNPMEALFNLIFKDETLHV.DTgaLV
  459-  503 (80.59/53.23)	LCDWAVSTHRFGIHRAIIVACLLEQLWCTFQSNTTSRQLFQ.DT..LV
  506-  550 (70.96/45.88)	LDNFSTTLPPFVGDQAPIDNEPMKSLVCLF.GELIDRQLFDhDA..YV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.37|      14|      16|    1065|    1078|       7
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 1065- 1078 (24.30/14.58)	ESNSRFSFVCRAIV
 1084- 1097 (25.07/15.28)	ETSERLNYLCSLCV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.70|      31|      36|    1923|    1957|       8
---------------------------------------------------------------------------
 1924- 1954 (53.02/24.16)	PSTSKALKRESSNASSM..LPPSLRPQSSNVPH
 1959- 1991 (48.68/25.62)	PSALQASRKHGSVGHGMnkLPPRSFGHDGGVPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.73|      17|      37|    1792|    1808|       9
---------------------------------------------------------------------------
  757-  766 (20.32/ 6.85)	SGGG.......AGGSGN
  769-  783 (21.13/ 7.43)	SGG.GTATTGSLSSTG.
 1792- 1808 (33.28/16.19)	SGGSGTGSLGKAGGAGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.39|      26|      33|     644|     669|      10
---------------------------------------------------------------------------
  644-  669 (48.82/26.94)	PCAPPTHGSHANNPEKPVQFGSTVTR
  680-  705 (47.57/26.05)	PIPQGECYAHEQNQRYQLLYGSVRAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.61|      26|      43|     940|     965|      12
---------------------------------------------------------------------------
  940-  965 (46.02/28.01)	SYMCLRAIGILQRYQPVLLTMSIAPR
  980- 1005 (47.59/29.23)	STQCFPSERCILAYVHGLFSSSCAVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.70|      13|      15|    1720|    1734|      13
---------------------------------------------------------------------------
 1720- 1734 (18.97/16.69)	LVHTFaaRNGLEGKP
 1738- 1750 (21.72/12.04)	LVKRL..RRELSERP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.98|      13|      16|    1393|    1405|      14
---------------------------------------------------------------------------
 1393- 1405 (25.27/21.25)	REICTVYWVRERF
 1412- 1424 (22.72/18.17)	RLICENVLIDKNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.40|      16|     950|     342|     357|      15
---------------------------------------------------------------------------
  342-  357 (33.54/16.98)	PP..VGDHFYLRGSPLDL
 1295- 1312 (28.86/13.59)	PPddDGDGNQGRGSDLDM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08266 with Med12 domain of Kingdom Metazoa
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