<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08258
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MGTRVSTKHKLISQLESADSILRDVLNAVAKRPTALNLEPLVELLLETDQQLKNTLMEVETQNELQKKIDALRADCAKSDKQIIACQVQLRKAEILLSTALYYSRQKLDTMATAVKNPIEVDELVRFAHRISATHGVSAPENWVQGDPRRPYPNREEIRRGYLGHLDDNGQFRSTLWDALAETATVAASSSHATPSSTSATGMSTTSTPGMNPGSNLPHMPNQPANSVTHHGTDSLGLSNSPNMILPGVNMVSSPVAAPPTNPSTWTGSNAAATSGTPSSAELSSPQASSNRPPASSLSAMLAGSGVGEPHPRVGPGLAPPPPPLRTIASQPVLGGTTGSRSAPGVGKLPGVGHRSAYALSPGVSVPQQQQSMHATSHPQIYAEPHATSTASPKAYAVQRKQTKYKSHHPEDVGTMSSDTSSDSSSGDD |
Length | 429 |
Position | Middle |
Organism | Echinostoma caproni |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Trematoda>
Digenea> Plagiorchiida> Echinostomata> Echinostomatoidea> Echinostomatidae>
Echinostoma.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.500 |
Instability index | 55.91 |
Isoelectric point | 7.29 |
Molecular weight | 45188.89 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
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GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP08258
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 154.24| 29| 29| 286| 314| 1
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255- 284 (35.54/10.28) PVAAPPTNPSTwTGSN..AAATSGTPSSAELS
286- 314 (49.25/16.64) PQASSNRPPAS.SLSA..MLAGSGVGEPHPRV
316- 346 (37.43/11.15) PGLAPPPPPLR.TIASqpVLGGTTGSRSAPGV
362- 386 (32.03/ 8.64) PGVSVPQ.QQQ.SMHA..TSHPQIYAEPH...
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 75.18| 22| 32| 194| 217| 2
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194- 217 (36.76/22.81) TPSSTSATGMSttSTPGMN.PGSNL
229- 251 (38.42/18.54) THHGTDSLGLS..NSPNMIlPGVNM
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