<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08257

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTIILAPYGIMADLVGLAQSEKSEEELVEEFETWSSFYPIRAQCEQVTDMNEPKQPFCVRTSQDAHGIRNAGNQRYTKSSADKRPSVTESSNEPTQSRPIFVDVLIGGFRVRYPFCYVLLPEPINDLKIWDGDKSFTCDGSSNPQPSSCCSQSVRVSTLPASNEPSVTESSLWRLKKRESRPTFRPRSAEALQDHLLFGNATLHSDLSFDVRRIFLAERVLERSSQCILSFTPQSSKEITAKCPIFARTGTFDDGSSYLRESEHGRYDLSESYVWSAQNPSAKCDXPERGTSRRSLVSFHQSENVTRQTLRNLVHEIDSFCERTQSPNTPIPAFSIPHDPSMPTLSPQQPTSSSTSTAIPNAAGNCQDKSSGEQQTNSDHILQPLTSGAAGPSAGIAASPSLPLISASGTMECNTPNPILASLPTSTLPNGLISVERHGSSSPANQTMKSAPQSSLSVVRKSIPNSWLTELATRANRVVSSEILKRPALCLSSVDAQDCEQTCLSDSLFPSVLKPFSPQGNLELSEDPPLDENYVTKAKRARLVANGPNINDPFSFSQYDNYSQGIMDHTQITDLQFDHVPVTPDTPLDATDLCDDFESGNSAGDLMPFSSSSMTSVANLNNNSILGRTLVLLPPSLDASEQLCLQQDRDFLKGVSLASSTGSGHIGPAELALMLPTPPSHDAPQPSPVDGVVTISASTPASGPKGSIVKTDSPVGHHFESSVPCTTDQSANTGHIPYSWSQSHLQANQTLLCLAKQPCAFSFNFSALDPDQDWSFSYPCVAYQGMSNNSNRQEMDLSAFKKTLPHLSFAFDHRILSTTPKSMSSDSVTVPVSLLSPEQSNTISCTVPGQRPTGLLSPMVGCGPTPQPTHREGCLTEQKVPSPSQTSWPPTNTVLSKAVSLPCVSDSDAVASSSPNREELAERLLGVTEADGLLVNIMLSDSMLNLFKDHNFDSCNICECTSSVLGSEIDVYLCNPTSTSNGSNSKAPRTSTSGMGSTGGAGSVNAFGTHDLVGASGFGFTRDCKCGFSAVMNQKFVVNGNLFFEDEIEVTNLSVRTERDSVRSNYSVVPTYRQSPGWWNFASAQTPLPLLQEIFRSVHDEFAVRHLSDYLRRCNLPSPFTVVKENMLEYDDACALVSAALEEASSVRGQTTVDSAERRILIHPSYMLKGQSRIPENHNDQIRLLTTMRPWLQEAISSTRLLESNYTVDGPLTWKAFHQLAGRGTDETCKPQPVPQIRVCSSDKEHLLISPFALRDWDRLSLAPLSRPKQLFYAVVIPLELEETNENDHKFNLAIPDQKDNVSGSTGHLHSEANVREAVTKTEGKKRITSCLSRFFLELSHTYENCKLGHHVPFHKPNMNRPETAFIPVYPREDESVVCDSTRNSVIPVDLFRTLVHQLQGQYCSPEVLLTKLQNYITAAASCTLNVLRERGVNVTPDNSSHQVTVACPLQPTELFPKSATHWTGKREEIKREVDKVTSDSKTKVRFDRQRTGSTRGHSSISPCNGQGSMTTSLDTSSWNKTSDAYLVIYLVNPFSQTCVAQDILSSLPSSWRPRVTIKLLPLDHVTTDYLPHLRSMALAIYSSVNRFIEPTLLNANRTLTGIGPAAEKELISNEKEGFHKRSIYAPAYTLVGPQDSLAHADVPPDSVERSSVLFVAYCLSQDQQWLLASFTDEQGSLLDQTFINISVPSSYFTDLELHKSQWSNHDRHYPSPRRIGLALLWDYMINLLSRTSNPWRVVIGRIGRLGHGELKGWNGLLGRKSLQDVNKFFREQCAACSASATIPASLSGNGTRATLNLVNSSSGANSCTHELPCLVSACLVSLEPQSTFRVYPGVGVGSSESWGGGGIGGGGGGGGSGSGGGGATGGGGGSGGPGGAFCGVSPSPFMTRTMMMVGNSTSASDIPTTTHILVFPTSTSASGHSEHDASALADVISGMGQDDMNVFEWLRSGNTELGDLDAHGNAAMLDALDNPAGLDFNLAGLSAAVGGAVVSDTPGSRSGGCHGLGDPGDHVLDQVDYSRGYDRVSDVVGMHSLASNVMDLAGGMCNGLSGPGGRFGGRVDDPSLPSSLLNTMPFGAHDPPVCIFDMDEVTNLMQQPLAMGYYISTAPTGPLPSWFWAACPHASFQYPVCLKSALHIQTSLVGMDDAAAVAAVGGAVPTVNSGPGGTGVAGSDRLAHLLDSTSTCDVLRYVLESYNALSWLTVNPITNDRRSCLPIHVLLLCQLYQALEAFM
Length2232
PositionMiddle
OrganismEchinostoma caproni
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Trematoda> Digenea> Plagiorchiida> Echinostomata> Echinostomatoidea> Echinostomatidae> Echinostoma.
Aromaticity0.07
Grand average of hydropathy-0.292
Instability index54.45
Isoelectric point5.49
Molecular weight240942.13
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08257
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.49|      14|      16|    1888|    1901|       2
---------------------------------------------------------------------------
 1888- 1901 (26.54/18.67)	TRTMMMV.GNSTSAS
 1905- 1919 (20.96/12.77)	TTTHILVfPTSTSAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.84|      13|      16|     843|     856|       3
---------------------------------------------------------------------------
  843-  856 (20.70/12.46)	ISCTvPGQRPT...GLL
  860-  875 (23.14/ 9.80)	VGCG.PTPQPThreGCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.64|      12|      17|     957|     968|       4
---------------------------------------------------------------------------
  957-  968 (22.52/11.72)	ICECTSSVLGSE
  973-  984 (23.12/12.26)	LCNPTSTSNGSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.88|      16|      18|     702|     717|       5
---------------------------------------------------------------------------
  667-  681 (19.75/ 7.91)	.GPAELALMLPTPPSH
  682-  697 (22.56/10.39)	DAPQPSPVDGVVTISA
  702-  717 (27.58/14.81)	SGPKGSIVKTDSPVGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      60.70|      18|      20|    1955|    1972|       6
---------------------------------------------------------------------------
 1955- 1969 (21.69/ 9.82)	.............G.DLDAHG.NAAMLDAL
 1970- 1990 (19.23/ 7.71)	DNP.........aGlDFNLAGlSAAVGGAV
 1993- 2016 (19.78/ 8.18)	DTPgsrsggchglG.DPGDH.....VLDQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.01|      59|     134|    1547|    1622|       7
---------------------------------------------------------------------------
  462-  524 (92.56/51.22)	SIPNSWLTELATR...ANRVVSSEI..LKRPALCL.SSVDaQDCEQTCLSDSlfpSVLKPFSPQGNLEL
 1547- 1611 (85.45/86.46)	SLPSSWRPRVTIKllpLDHVTTDYLphLRSMALAIySSVN.RFIEPTLLNAN...RTLTGIGPAAEKEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.29|      20|      20|     758|     777|       8
---------------------------------------------------------------------------
  758-  776 (30.65/18.75)	.......P.CAFSFNFSALDPDQDWSF
  777-  797 (27.94/16.23)	S.....yP.CVAYQGMSNNSNRQEMDL
  798-  823 (18.69/ 7.64)	SafkktlPhLSFAFDHRILSTTPK.SM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.26|      43|      44|    2040|    2083|       9
---------------------------------------------------------------------------
 2053- 2097 (73.48/31.60)	GGRFGGRVDDPSLPSSLLNTMPFGAHDPPVC...................ifDM.DEVTNLMQQP
 2100- 2164 (64.78/30.51)	MGYYISTAPTGPLPSWFWAACPHASFQYPVClksalhiqtslvgmddaaavaAVgGAVPTVNSGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.27|      36|      42|    1747|    1786|      11
---------------------------------------------------------------------------
 1747- 1786 (52.94/45.16)	GHGELKGWNgLLGRKSlqDVNKFFRE.QC..AACSASATiPAS
 1789- 1827 (56.32/32.55)	GNGTRATLN.LVNSSS..GANSCTHElPClvSACLVSLE.PQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.09|      21|      44|     347|     367|      12
---------------------------------------------------------------------------
  322-  343 (28.25/11.09)	E.rTQSPNTPIPAFSIPHDPSMP
  344-  366 (30.84/12.87)	TlsPQQPTSSSTSTAIPNAAGNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.31|      17|      20|    1102|    1118|      16
---------------------------------------------------------------------------
 1102- 1118 (31.78/19.88)	FAV..RHLSDYLRRCNLPS
 1120- 1138 (25.53/14.47)	FTVvkENMLEYDDACALVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.26|      11|      19|     567|     578|      18
---------------------------------------------------------------------------
  567-  578 (16.90/15.52)	MDHTQITDlQFD
  588-  598 (20.35/12.92)	LDATDLCD.DFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.56|      30|     325|     722|     754|      19
---------------------------------------------------------------------------
  724-  753 (57.37/24.51)	PCTTDQSANTGHIPYSWSQSHLQANQTLLC
  876-  896 (32.74/10.67)	...TEQ.....KVP.SPSQTSWPPTNTVLS
 1503- 1523 (29.45/ 6.56)	PCNGQGSMTTSLDTSSWNKTS.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.59|      17|      44|     174|     190|      20
---------------------------------------------------------------------------
  174-  190 (29.83/16.92)	RLKKRESR..PTFRPRSAE
  219-  237 (23.76/11.82)	RVLERSSQciLSFTPQSSK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08257 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GPAELALMLPTPPSHDAPQPSPVDGVVTISA
2) TQSPNTPIPAFSIPHDPSMPTLSPQQPTSSSTSTAIPNAAGNCQDKSSGEQQTNSDHILQPLTSGAAGPSAGIAASPS
3) WGGGGIGGGGGGGGSGSGGGGATGGGGGSGGPGGAFC
667
324
1843
697
401
1879










Molecular Recognition Features






MoRF SequenceStartStop




NANANA