<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08249

Description Mediator of RNA polymerase II transcription subunit 13
SequenceAGDKGSWENGLSYECRSLLFKALHNVIESSHHASFSFTFFVHGDSTVCTSMDIREHPPVRLLTMRHLEEAQQAQQAAPSAGPNGPASPSMAGVPGSGSNTPGSPGAAGTGGAAGAASGSATIASTDAIEPREVILAPFGLAGTLTGQSYKASDPHVQKLLDDWSAFYPISNKLSSSTEDGSDNVPPMVEILVGKLKMRYPTKYVLVADMDDWTATDGRSNSSSASSNNNNNSNSSSNSNQTATPITAIPTIAASVLSRANNSNASEQRSSSGGCPINSTSNQLTTGGTGGTSNGNAPPTTNTTTMARNRDSSAESSSAAAPSPTGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINKSPAVILPERVWQDCIMHAPSSQTTSASSSSGSSAASNGSQSTPGSGVTIKTEPKDTSGSGGSNGTSSSSNASASNSSTSGGGGDENSSGAANGVDANGNTSVWEISDPTVKVSCCCIKCCKRPPSSASSTSTSSSSASSLAGGRLAQHQQQHAIGAAVSSSAAAGLATLYTSTPSPGGAGGAGGGMVVHPKSSYSITYAGGGGSNRGEKYHHHHHSGGGQSHKDHHHHHHHHRPPRVAFHKRPPQEALFRPGVKPLSLTAAAALAASAAAAAAAGSASTAANASSPGAVSSGDSAADSLELADSCLRSNQNCAANSNSGAGAANSTGAAAGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGGGAGGGGLTGNSGNSTEAQQQQQSISNMGNSSNSNSSNSSSNSSSLNALKTTSSPRSTLSSGIGSLKVRSESSLGAAGSGGSSLGGGGGVPMTPSIHSVYSSAHQTAVANNLASKRESILQMLQSLKRPSLFCKDYETLQGEDIPSTSQLLYDYTCVDAWMNHPVKRMRLAMEEHRLVKKIRNLDLYANEHSRTMTAGFGGHAGGHGGERIGANGMLMKGAGEASDPLADALGGHNGGGGGACDNGASNNIGGGGCPTLLGHGQIKMEIGCDGGGGQGGGGGAGLPGSGMGGANGTPDRNGPSAGNGDGTLLGEHEIKKEKEEKGPIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSCTGSGGFSEEGKRFPGSNHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGIAIDTLVDLQMSLSSGAGSGPAGAGPVLPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPTLPSQLILPQIPASTTNLVYKSTRQKQKEQAAAEREKQKLREQAEREREQQQQQQDQQHNSQSEHNAQSTAASGATGDRIGIGGPAGGGVGLGLLPIIKQEAGNLTIPQPLSTPNSLLGGLNNMNGSLNHPYSNPPSQGAQSQPHSRPPSVNSLPGGIIGSGAGMLSPSPAGAGSSGALYHPAIGAIPLPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAGPAGSPNPMGSLNFRRATPLLPPPPYDVAIASPANSVATPSSYHSKQFPLEGVDTSGGPGSNRGPMTPSSTGPMGTTVNQPLSSTGVGCASGVVGPNSVAPGTRSASIETSALLVNVLLYDTALNIFRDHNFKSCTLCVCNAGTKCVGNIRGADSGLYLALPGTNWMDSVTAPADGASGAGGAGAVGGSRSKANALAHLGLGSGGGSSAFGGMLGSPAVAGANSDKTITINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKKSSLFEFLNGTAKAIKMEESIGGGSNGVGGTLATPGGAASASTGGTDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGPLFGRGAESGAVHLLEYVDANDVISLALEQGRLQAINESKMDVDQQQPASASSSSSSSPGSGALVKGGTLRGVMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDFVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKTGSSSSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTPSASSGSASVSGGGSGASSLGSGSMNQPGGNGMGQNRGDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSDNRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPDWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2845
PositionMiddle
OrganismAnopheles stephensi (Indo-Pakistan malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.446
Instability index53.47
Isoelectric point6.18
Molecular weight295405.22
Publications
PubMed=25244985

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP08249
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|    1403.30|     244|     264|     286|     549|       4
---------------------------------------------------------------------------
  103-  286 (203.90/63.54)	SPGaaGTGGAA......GA...........................asgSATIASTDAIEPREVILAPFGLAGTLTG.....QSYKASDPHVQKLL...D.DWSAFY.....PISNKL..S.SS.TEDGsdNVPPMVEILVGKlkmrYPTkyVLVAD............................................MDD...WTATDGRS........................N..SSSASSNNN.NNSNS.S......SNS...............NQ....................T..A..TP....................................................ITAI.....PTIAAS.....VLSRANNSNASEQRSSS.G.....GCPIN...S..TSNQLTTG.................................................
  287-  538 (363.01/120.16)	..................................................GTGGTSNGNAPPTTNTTTMARNRDSSA.....ESSSAAAPSPTGTL...R.QRNHHKSMMTPPLTVPE..S.PS.NDLG..NPLSMSSALINK....SPA..VILPERVWQD.....................................CIMHA...PSSQTTSA........................S..SSSGSSAAS.NGSQS.T......PGS...............GV....................TIKT..EPKD.....tsgsggsngtssssnasasnS.STSGGGGDENSSGAANGVDAN.GNTSVWEISDPTVKVSCCCIKCCKRPPSSASSTSTSSS.SASSLAGGRLA...Q..HQQQHAIG............A.AVSSSAAAGLATL.................YTSTP
  539-  704 (162.59/48.84)	SPG..GAGGAG......GGmvvhpkssysityaggggsnrgekyhhhhhSGGG.................Q...................SH.......K.DHHHHHHHHRP....................................PR..VAFHKRPPQE.....................................ALFRPgvkPLSLTAAA........................A.lAASAAAAAA.AGSAS.TaanassPGA................V..........................................................SSGDSAADSLELADSCLRSN.QN................C..............................A...A..NSNSGA.G............A.ANSTGAAAGSTTP.................YGGPP
  705-  887 (178.22/54.40)	S...................................................................................................yCRN........PMSIGD..ShPL.PSEG..SP...ASA........APS..PMQPSSVSQ..............................................PTSVPSGD........................QliTMSPHPPAS.NNPRSvQ......PGT...............PCldhldkntpaptptdqhdskSINA..SPYH.........................TpSHPGGGGGGAGGG...GLTGNsGN.ST.EAQQQQQSIS.......NMGNSSNSNSSNSSS.NSSSLNALKTTsspR..STLSSGIG............SlKVRSESSLGAA.......................G
  888- 1086 (196.56/60.92)	SGG..SSLGGG......GG...........................vpmTP....SIHSVYSSAHQTAVANNLASKR.....ES.................ILQMLQSLKRPSLFCKD..Y.ET.LQ.G..EDIPSTSQLLYD....YTC..V....DAW.........................................MNH...PVKRMRLAmeehrlvkkirnldlyanehsrtmT..AGFGGHAGG.HGGER.I......GAN...............GM....................LMKGagEASD...................pladalG.GHNGGGGGACDNGASNNIGGG.GCPTLLGHGQIKMEIGC.................DGG........GG...........Q......................................................
 1087- 1323 (187.11/57.56)	..G..GGGGAGlpgsgmGG..........................................................angtpDRNGPSAGNGDGTLlgeH.EIKKEKEEKGPIFLTDQdlQ.PSiDDL...NQIFDDGGPFND....DP............D.......................................LH.....NTPPGSN........................K..SCTGSGGFS.EEGKR.F......PGSnhhsvnsgmlspkelSQ....................MFPT..PP................................SLDPHPNSSPGGGGCLSD.GGIAIDTLVDLQM..................SLSSGAG.SGPAGAGPVLP...NlgSPQEEPIDdwsfvflpppicP.YVGSSKYAPLPTLpsqlilpqipasttnlvYKST.
 1469- 1640 (111.91/30.80)	SPA..GAGSSG......A................................................................................................................................................lyhpaigaiplplrqgmspispatpggsmrvptpqgsCPLPY...PSPLGGAG........................P..AGSPNPMGSlNFRRA.T......P.......................................LLPP..PPYDvaiaspansvatpssyhskqfplegV.DTSGGPGSNRGPMTPSSTGPM.GTT....VNQPLSSTGVGCASGVV.GPNSVAPGTRSASiETSAL.....................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     177.67|      34|     206|    1923|    1959|       5
---------------------------------------------------------------------------
 1418- 1450 (47.92/15.07)	LGGLNNMN..GS.LNHPYSN...P.PSqgAQSQPHSRPPS..
 1923- 1956 (58.41/20.82)	QGRLQAIN..ESKMDVDQQQ...P.AS..ASSSSSSSPGSGA
 2180- 2216 (43.88/13.12)	LSKVPS.D..KSLLDPPESHhhtPsAS..SGSASVSGGGSGA
 2661- 2688 (27.47/ 6.05)	..GINMMDvfKCWDDLPMQQinmP..........HSRPGS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     336.49|     103|     500|    2217|    2326|       6
---------------------------------------------------------------------------
 2217- 2326 (180.72/84.46)	SSLGSGSMNQPGGNGMGQNRGDGPGQSPMPPPPPSTPDSSQPGDKAPN........................TPKFDHDSDNRDQLNTSSA.SPADGmRIDDDgkdpphIVLYIVEPFT....CGNDSPDVERLACLSL
 2698- 2829 (155.77/61.26)	SPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPDwfwsscphmenvcpvflrtalhlhSPTILQNTDDPLQQNQSSTeHPLDS.NITAD......VLRYVLEGYNllswLAMDSNTHDRLSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.57|      24|     419|    2108|    2131|       7
---------------------------------------------------------------------------
 2108- 2131 (44.60/29.11)	KLGR..HTPIKGWDGIL.RVGSQRVLK
 2527- 2553 (36.96/22.60)	RIGRigHGELKGWSWLLsKPNLQRASK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.62|      52|      95|    1756|    1810|       9
---------------------------------------------------------------------------
 1756- 1810 (86.58/57.92)	TINTDSLQNGYLDEDPIDCQCgfSAVVNRRMA.HRAGLFYEDEMEITGmAEDPAVH
 1854- 1906 (88.04/48.62)	TGGTDSLPLTLKVMDLLREQC..SVVQSSSNSiHRAVNRYRGPLFGRG.AESGAVH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08249 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAGSASTAANASSPGAVSSGDSAADSLELADSCLRSNQNCAANSNSGAGAANSTGAAAGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGGGAGGGGLTGNSGNSTEAQQQQQSISNMGNSSNSNSSNSSSNSSSLNALKTTSSPRSTLSSGIGSLKVRSESSLGAAGSGGSSLGGGGGVPMTPSIHSVYS
2) ASSTSTSSSSASSLAGGRLAQHQQQHAIGAAV
3) ATDGRSNSSSASSNNNNNSNSSSNSNQTATPITAIPTIAASVLSRANNSNASEQRSSSGGCPINSTSNQLTTGGTGGTSNGNAPPTTNTTTMARNRDSSAESSSAAAPSPTGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINKSPAVILPERVWQDCIMHAPSSQTTSASSSSGSSAASNGSQSTPGSGVTIKTEPKDTSGSGGSNGTSSSSNASASNSSTSGGGGDENSSGAANGVDANGNTSVW
4) EAGNLTIPQPLSTPNSLLGGLNNMNGSLNHPYSNPPSQGAQSQPHSRPPSVNSLPGGIIGSGAGMLSPSPAGAGS
5) LAPYLSKVPSDKSLLDPPESHHHTPSASSGSASVSGGGSGASSLGSGSMNQPGGNGMGQNRGDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSDNRDQLNTSSASPADGMRIDDDGKD
6) LRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAGPAGSPNPMGSLNFRRAT
7) MEIGCDGGGGQGGGGGAGLPGSGMGGANGTPDRNGPSAGNGDGTLLGEHEIKKEKEEKGPIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSCTGSGGFSEEGKRFPGSNHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLS
8) NLVYKSTRQKQKEQAAAEREKQKLREQAEREREQQQQQQDQQHNSQSEHNAQSTAASGATGDRIGIGGPA
9) PSSYHSKQFPLEGVDTSGGPGSNRGPMTPSSTGPMGTTVNQPL
10) PVRLLTMRHLEEAQQAQQAAPSAGPNGPASPSMAGVPGSGSNTPGSPGAAGTGGAAGAA
11) QINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSE
12) SITYAGGGGSNRGEKYHHHHHSGGGQSHKDHHHHHHHHRPPRVAFHKRPPQEALFRPGVK
13) VDLQMSLSSGAGSGPAGAGPVLPNLGSPQEEPID
636
491
214
1401
2176
1491
1076
1317
1567
58
2678
559
1243
910
522
467
1475
2297
1545
1233
1386
1609
116
2719
618
1276










Molecular Recognition Features






MoRF SequenceStartStop




1) AALAASAAAA
2) RVAFHKR
626
600
635
606