<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08249

Description Mediator of RNA polymerase II transcription subunit 13
SequenceAGDKGSWENGLSYECRSLLFKALHNVIESSHHASFSFTFFVHGDSTVCTSMDIREHPPVRLLTMRHLEEAQQAQQAAPSAGPNGPASPSMAGVPGSGSNTPGSPGAAGTGGAAGAASGSATIASTDAIEPREVILAPFGLAGTLTGQSYKASDPHVQKLLDDWSAFYPISNKLSSSTEDGSDNVPPMVEILVGKLKMRYPTKYVLVADMDDWTATDGRSNSSSASSNNNNNSNSSSNSNQTATPITAIPTIAASVLSRANNSNASEQRSSSGGCPINSTSNQLTTGGTGGTSNGNAPPTTNTTTMARNRDSSAESSSAAAPSPTGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINKSPAVILPERVWQDCIMHAPSSQTTSASSSSGSSAASNGSQSTPGSGVTIKTEPKDTSGSGGSNGTSSSSNASASNSSTSGGGGDENSSGAANGVDANGNTSVWEISDPTVKVSCCCIKCCKRPPSSASSTSTSSSSASSLAGGRLAQHQQQHAIGAAVSSSAAAGLATLYTSTPSPGGAGGAGGGMVVHPKSSYSITYAGGGGSNRGEKYHHHHHSGGGQSHKDHHHHHHHHRPPRVAFHKRPPQEALFRPGVKPLSLTAAAALAASAAAAAAAGSASTAANASSPGAVSSGDSAADSLELADSCLRSNQNCAANSNSGAGAANSTGAAAGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGGGAGGGGLTGNSGNSTEAQQQQQSISNMGNSSNSNSSNSSSNSSSLNALKTTSSPRSTLSSGIGSLKVRSESSLGAAGSGGSSLGGGGGVPMTPSIHSVYSSAHQTAVANNLASKRESILQMLQSLKRPSLFCKDYETLQGEDIPSTSQLLYDYTCVDAWMNHPVKRMRLAMEEHRLVKKIRNLDLYANEHSRTMTAGFGGHAGGHGGERIGANGMLMKGAGEASDPLADALGGHNGGGGGACDNGASNNIGGGGCPTLLGHGQIKMEIGCDGGGGQGGGGGAGLPGSGMGGANGTPDRNGPSAGNGDGTLLGEHEIKKEKEEKGPIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSCTGSGGFSEEGKRFPGSNHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGIAIDTLVDLQMSLSSGAGSGPAGAGPVLPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPTLPSQLILPQIPASTTNLVYKSTRQKQKEQAAAEREKQKLREQAEREREQQQQQQDQQHNSQSEHNAQSTAASGATGDRIGIGGPAGGGVGLGLLPIIKQEAGNLTIPQPLSTPNSLLGGLNNMNGSLNHPYSNPPSQGAQSQPHSRPPSVNSLPGGIIGSGAGMLSPSPAGAGSSGALYHPAIGAIPLPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAGPAGSPNPMGSLNFRRATPLLPPPPYDVAIASPANSVATPSSYHSKQFPLEGVDTSGGPGSNRGPMTPSSTGPMGTTVNQPLSSTGVGCASGVVGPNSVAPGTRSASIETSALLVNVLLYDTALNIFRDHNFKSCTLCVCNAGTKCVGNIRGADSGLYLALPGTNWMDSVTAPADGASGAGGAGAVGGSRSKANALAHLGLGSGGGSSAFGGMLGSPAVAGANSDKTITINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKKSSLFEFLNGTAKAIKMEESIGGGSNGVGGTLATPGGAASASTGGTDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGPLFGRGAESGAVHLLEYVDANDVISLALEQGRLQAINESKMDVDQQQPASASSSSSSSPGSGALVKGGTLRGVMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDFVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKTGSSSSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTPSASSGSASVSGGGSGASSLGSGSMNQPGGNGMGQNRGDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSDNRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPDWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2845
PositionMiddle
OrganismAnopheles stephensi (Indo-Pakistan malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.446
Instability index53.47
Isoelectric point6.18
Molecular weight295405.22
Publications
PubMed=25244985

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08249
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|    1403.30|     244|     264|     286|     549|       4
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  103-  286 (203.90/63.54)	SPGaaGTGGAA......GA...........................asgSATIASTDAIEPREVILAPFGLAGTLTG.....QSYKASDPHVQKLL...D.DWSAFY.....PISNKL..S.SS.TEDGsdNVPPMVEILVGKlkmrYPTkyVLVAD............................................MDD...WTATDGRS........................N..SSSASSNNN.NNSNS.S......SNS...............NQ....................T..A..TP....................................................ITAI.....PTIAAS.....VLSRANNSNASEQRSSS.G.....GCPIN...S..TSNQLTTG.................................................
  287-  538 (363.01/120.16)	..................................................GTGGTSNGNAPPTTNTTTMARNRDSSA.....ESSSAAAPSPTGTL...R.QRNHHKSMMTPPLTVPE..S.PS.NDLG..NPLSMSSALINK....SPA..VILPERVWQD.....................................CIMHA...PSSQTTSA........................S..SSSGSSAAS.NGSQS.T......PGS...............GV....................TIKT..EPKD.....tsgsggsngtssssnasasnS.STSGGGGDENSSGAANGVDAN.GNTSVWEISDPTVKVSCCCIKCCKRPPSSASSTSTSSS.SASSLAGGRLA...Q..HQQQHAIG............A.AVSSSAAAGLATL.................YTSTP
  539-  704 (162.59/48.84)	SPG..GAGGAG......GGmvvhpkssysityaggggsnrgekyhhhhhSGGG.................Q...................SH.......K.DHHHHHHHHRP....................................PR..VAFHKRPPQE.....................................ALFRPgvkPLSLTAAA........................A.lAASAAAAAA.AGSAS.TaanassPGA................V..........................................................SSGDSAADSLELADSCLRSN.QN................C..............................A...A..NSNSGA.G............A.ANSTGAAAGSTTP.................YGGPP
  705-  887 (178.22/54.40)	S...................................................................................................yCRN........PMSIGD..ShPL.PSEG..SP...ASA........APS..PMQPSSVSQ..............................................PTSVPSGD........................QliTMSPHPPAS.NNPRSvQ......PGT...............PCldhldkntpaptptdqhdskSINA..SPYH.........................TpSHPGGGGGGAGGG...GLTGNsGN.ST.EAQQQQQSIS.......NMGNSSNSNSSNSSS.NSSSLNALKTTsspR..STLSSGIG............SlKVRSESSLGAA.......................G
  888- 1086 (196.56/60.92)	SGG..SSLGGG......GG...........................vpmTP....SIHSVYSSAHQTAVANNLASKR.....ES.................ILQMLQSLKRPSLFCKD..Y.ET.LQ.G..EDIPSTSQLLYD....YTC..V....DAW.........................................MNH...PVKRMRLAmeehrlvkkirnldlyanehsrtmT..AGFGGHAGG.HGGER.I......GAN...............GM....................LMKGagEASD...................pladalG.GHNGGGGGACDNGASNNIGGG.GCPTLLGHGQIKMEIGC.................DGG........GG...........Q......................................................
 1087- 1323 (187.11/57.56)	..G..GGGGAGlpgsgmGG..........................................................angtpDRNGPSAGNGDGTLlgeH.EIKKEKEEKGPIFLTDQdlQ.PSiDDL...NQIFDDGGPFND....DP............D.......................................LH.....NTPPGSN........................K..SCTGSGGFS.EEGKR.F......PGSnhhsvnsgmlspkelSQ....................MFPT..PP................................SLDPHPNSSPGGGGCLSD.GGIAIDTLVDLQM..................SLSSGAG.SGPAGAGPVLP...NlgSPQEEPIDdwsfvflpppicP.YVGSSKYAPLPTLpsqlilpqipasttnlvYKST.
 1469- 1640 (111.91/30.80)	SPA..GAGSSG......A................................................................................................................................................lyhpaigaiplplrqgmspispatpggsmrvptpqgsCPLPY...PSPLGGAG........................P..AGSPNPMGSlNFRRA.T......P.......................................LLPP..PPYDvaiaspansvatpssyhskqfplegV.DTSGGPGSNRGPMTPSSTGPM.GTT....VNQPLSSTGVGCASGVV.GPNSVAPGTRSASiETSAL.....................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     177.67|      34|     206|    1923|    1959|       5
---------------------------------------------------------------------------
 1418- 1450 (47.92/15.07)	LGGLNNMN..GS.LNHPYSN...P.PSqgAQSQPHSRPPS..
 1923- 1956 (58.41/20.82)	QGRLQAIN..ESKMDVDQQQ...P.AS..ASSSSSSSPGSGA
 2180- 2216 (43.88/13.12)	LSKVPS.D..KSLLDPPESHhhtPsAS..SGSASVSGGGSGA
 2661- 2688 (27.47/ 6.05)	..GINMMDvfKCWDDLPMQQinmP..........HSRPGS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     336.49|     103|     500|    2217|    2326|       6
---------------------------------------------------------------------------
 2217- 2326 (180.72/84.46)	SSLGSGSMNQPGGNGMGQNRGDGPGQSPMPPPPPSTPDSSQPGDKAPN........................TPKFDHDSDNRDQLNTSSA.SPADGmRIDDDgkdpphIVLYIVEPFT....CGNDSPDVERLACLSL
 2698- 2829 (155.77/61.26)	SPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPDwfwsscphmenvcpvflrtalhlhSPTILQNTDDPLQQNQSSTeHPLDS.NITAD......VLRYVLEGYNllswLAMDSNTHDRLSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.57|      24|     419|    2108|    2131|       7
---------------------------------------------------------------------------
 2108- 2131 (44.60/29.11)	KLGR..HTPIKGWDGIL.RVGSQRVLK
 2527- 2553 (36.96/22.60)	RIGRigHGELKGWSWLLsKPNLQRASK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.62|      52|      95|    1756|    1810|       9
---------------------------------------------------------------------------
 1756- 1810 (86.58/57.92)	TINTDSLQNGYLDEDPIDCQCgfSAVVNRRMA.HRAGLFYEDEMEITGmAEDPAVH
 1854- 1906 (88.04/48.62)	TGGTDSLPLTLKVMDLLREQC..SVVQSSSNSiHRAVNRYRGPLFGRG.AESGAVH
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08249 with Med13 domain of Kingdom Metazoa
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