<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08244

Description Uncharacterized protein
SequenceMNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKHGFATEHKLSEEFGTARNYNVSASKVGAYFNAILAKKEELMTLPDSGRKKQQINPKDNFWPVTARNKTTLDTWFKDLAGTKPLSSLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFMKDLIPKLHEHYHQGPLQEKPSAGSTGSSGGMGGASGGGGGVGGGGLGMSAGAGGTNPSTIPPPLSSPAGSMHSPAGGNPVGGSMHGQQQQQQQQQQQQQPISPQEEQRIAQRQWNYSTQLCKYMYEEGLLDKQEFLNWIIDLLEKMKSSPNADDGLLRIYLPLAMQYLHDIVQSERFCRRLAYAVSKKLAQLINQMAESHNINLSSADPDGNGKPASSELAESKQADKQHDKPPKEGPNGSAAPPADSGPPKVNPYEMIFTEYSHCSHHRDVVQQLSSILQVITLECPTALVWCGVGETRSSSVLSGSPLDHLPVAPSALPMPNRYVKSNEDIRRQLFEAEESIKVRSRHAESRWCIDKWQTAAGNASLKILATLDALDGHCFDRMDSNNSLDSLYSKIFPPFQVQQIKPAESTAGAGGSGQGNGASGGVNAADGKDAATKQFEYNVEQDSSIVKILCEWAVSWQRWGEHRAMVVAWLLDKRQNEVLTALENDSYTNNLNSSDDKDSVLSGSGLNGGQPVFQHILMNFLDHDAPVLEEAGSSQNKSQFTNLVHLFSELIRHDVFSHDAYMCCLISRGDLLTGAGGMLSLDSHGICNAGLGTGPISNKPATSSSPNNGGGMEDDVLQTDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEHAAPSVTGLGKAESSSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRSEFNFESTSNKCQAMSYFDQHVVTWQCAVQVQEMLNAFAIGNSNYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILRELPEVELQLIGKSSMALVRSYTTSLSLYVVGVLRRYHCCLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSACSSLKARPQQEPFHNAYPKIKQALYTPLQPTPSAHTYNPQFMLEIITNPRRGGKIESAWARQLNESASNRYSFVCNAVVAVTRDIDNDCLNDIAAMCAELTACCNSLSTEWLGVLIALCGSNRDAGYYVDVLTQVDVQNTNIHNALSVFTSILVARHCFSLENFVAHVALPSLVQACKGRGETTPEIEAGARLSCHLLLRLFKTIECPQPGLYSVSTSPNPITVGNAHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATAHKVSSIFGTGKRSGLNTPVHPGSTPKSMAGSGDLSHILGTSDLSILGNPDESMLDVSQQNSHLNQENATSLSDFAQHVLRQICSQEWVLERCLQHAEELCQHGMLIDNLLTAKQAQRLLHMICYPEHESNLIAELDQKAIIVRILENLEQWSLRISWLDLQLMFKQTNCSSPDLSNWLDMVARAAIDVFRVNEFVLSNPEHVKQEKIKPSTWLVAPLVSKLPSAVQGRILKVSGQVLESTSMFSKHKDGSGGNSGGSNNNSHNHGANSNSSVSSNGSTFGSKKSSQLNHQPFLGLVLTCLKGQDEQKEGLLQSLYSQLSQFLQNRDQSLETIGGIEDPCGFEKMLDALQLRYSLVGGLFDAIMKNATSTTDWAILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSQTERDENKKLYTNLMKKLRKELGDKNGPSIKYVRQLLPLAKQTCEVLTCDSAGSSTDAKGNKIAIDSIEKKNGLRLGDKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLYKPSSYYYEPLPLPPEEVEPLPDKLKDDMKADTPSSDQSPAPSTGSKKSKTTRKRKPKATPAAQVQQSQPQQPIMPAIVPQTAAGPQQLQQMQQQQQQQQQMQQQTLQQQQHLQQQQQQQLHLQQQQAQQQQHLQQQQQLQQLQQQQQLQQQQQQQQNQMMMQQQQQPNIPQQQQSALQQQQQQQLGSQQPQQQQVAMTPQQTLQQMQNNSMGSMQMGGPMSSMNQQHLQQQYGQANPAQLVGQGNIGGMQAGMGGLGTGMGGGMLGQQQQQQQQQQQQPPQQQQQPQQAQQAQQAQQQAQQQQQQQQQQQQQQPQGNPNMGFVGNVNPMAQLAQQQGGNQQQWGGYGSMQQQHQQQQQQQQQQQQQQQPQPQAQQQQQQQQQQQTPQQAQQAAQQQGPQQGPQQGSQQGPQTQQQLQQQQQQQQMFYSSMGQATMNRFDRPQLNNSKQALSNMLRSKLPINAGHPASFMQQQQQQQQQQQQQQQQQQPQRNPQQQFMRGPLRAGMPGNPIVGAQAGMGPMNPAMAGANAGIGATGGGAVMGAQGMNPGGMMGAQQAAQGQQTAGGIMNQNAPAMMSTAGGSLMGQSGGSMIQTSMMNPQQNPTLVGQGMGSGGGIGGGAGGMTGNSGMGGSATGMGGSGSGMVTSGGMVSTGMGSAGIGNAAPMGGGQGGMGGNSGMPNAGGMGNPAMGNPGMGMQNMQQSGSMQGGMFQGQNVPYQSVNQNYPNYGNQGMGQQGGQGGGMMGNFNQMAQQQRNTQAEFLAQQRAAAMAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGGNMAQNQQQFQQQRMRLIMQQHSGMGQGGNAQGMMQNQGQGMSTQQTPNLVAQLQRQMPNQSNMMGQQYPHQPPQY
Length2797
PositionKinase
OrganismAnopheles stephensi (Indo-Pakistan malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.640
Instability index55.86
Isoelectric point6.92
Molecular weight305634.91
Publications
PubMed=25244985

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08244
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            15|     801.82|      41|      48|    2192|    2232|       1
---------------------------------------------------------------------------
 1988- 2032 (56.87/11.10)	M..........P......aivPQT..AAGPQQLQQMQQQ...QQQQ.QQMQ......QQtlQQ....................QQHlQ.........QQQQ...Q
 2033- 2072 (62.05/12.81)	Q..........L.........HLQ..QQQAQQQQHLQQ....QQQL.QQLQ......QQ..QQ....................LQQ.Q.........QQQQ.QNQ
 2073- 2109 (58.14/11.52)	M..........M.........MQQ..QQQPNIPQQQQSA...LQQQ.QQQQ......LG..SQ....................QPQ.Q.........QQ.....V
 2111- 2151 (57.29/11.24)	M..........T.........PQQ..TLQQMQNNSMGSM...QMGG.PMSS......MN..QQ....................HLQ.Q.........QYGQ.ANP
 2154- 2190 (46.77/ 7.78)	L..........V.........GQG..NIGGMQAGMGGLG...TGMG.GGML......G...QQ....................QQQ.Q.........QQ.Q...Q
 2192- 2232 (84.16/20.09)	Q..........P.........PQQ..QQQPQQAQQAQQA...QQQA.QQQQ......QQ..QQ....................QQQ.Q.........QQPQ.GNP
 2241- 2277 (47.77/ 8.11)	N..........P.........MAQ..LAQQQGGNQQQWG...GYGSmQQQH......QQ..QQ....................QQQ.Q.........QQ......
 2278- 2312 (59.72/12.04)	......................QQ..QQQPQ..PQAQQQ...QQQQ.QQQQ......TP..QQ....................AQQ.A.........AQQQ.G.P
 2314- 2359 (45.55/ 7.38)	Q..........G.........PQQgsQQGP.QTQQ..QL...QQQQ.QQQQmfyssmGQ..AT....................MNR.F.........DRPQ.LNN
 2362- 2406 (55.30/10.59)	Q..........AlsnmlrsklPIN..AGHP.....ASFM...QQQQ.QQQQ......QQ..QQ....................QQQ.Q.........QQPQ.RNP
 2453- 2516 (42.09/ 6.24)	V..........M.........GAQ..GMNPGGMMGAQQAaqgQQTA.GGIM......NQ..NApammstaggslmgqsggsmiQTS.M.........MNPQ.QNP
 2556- 2605 (43.44/ 6.68)	MvtsggmvstgM.........GSA..GIGNAAPMGGGQG...GMGG..NSG......MP..NA....................G.G.M.........GNPAmGNP
 2606- 2643 (47.89/ 8.15)	G..........M.........GMQ..NMQQSGSM...QG...GM.F.QGQN......VP..YQ....................SVN.Q.........NYPNyGNQ
 2644- 2694 (47.82/ 8.13)	G..........M.........GQQ..GGQGGGMM.GNFN...QMAQ.QQRN......TQ..AE..................flAQQ.RaaamaagrgQYGQ.HAP
 2701- 2738 (46.97/ 7.85)	M..........G.........VNQ..GAVPPYPRQGG.....KPGV.GG.N......MA..QN....................QQQ.F.........QQQR.MRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.85|      19|      20|    2411|    2430|       3
---------------------------------------------------------------------------
 2409- 2428 (29.54/12.29)	QFMrGPLRAGMPG.NPIVGAQ
 2429- 2448 (33.31/11.05)	AGM.GPMNPAMAGaNAGIGAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.93|      14|      15|    1618|    1631|       4
---------------------------------------------------------------------------
 1618- 1631 (27.03/16.23)	HKDGSGGNSGGSNN
 1634- 1647 (25.90/15.15)	HNHGANSNSSVSSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.72|      16|      20|    2753|    2769|       5
---------------------------------------------------------------------------
 2753- 2769 (28.16/18.88)	QGMMQNQGQGMStQQTP
 2776- 2791 (33.56/18.28)	QRQMPNQSNMMG.QQYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.00|      20|      20|    1167|    1186|       7
---------------------------------------------------------------------------
 1167- 1186 (32.84/22.96)	RQLNESASNRYSFVCNAVVA
 1189- 1208 (34.16/24.21)	RDIDNDCLNDIAAMCAELTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.50|      18|      21|    1362|    1382|      10
---------------------------------------------------------------------------
 1363- 1382 (26.09/24.76)	GI.LVVGDATAHKvsSIFGTG
 1386- 1404 (27.40/12.64)	GLnTPVHPGSTPK..SMAGSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.78|      13|      23|    1694|    1709|      11
---------------------------------------------------------------------------
 1694- 1709 (15.20/20.62)	LQNRdQSLetIGGIED
 1720- 1732 (24.57/15.46)	LQLR.YSL..VGGLFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.18|      20|      20|    1563|    1582|      17
---------------------------------------------------------------------------
 1563- 1582 (33.83/29.00)	VNEFVLSNPEHVKQEKIKPS
 1586- 1605 (31.35/26.08)	VAPLVSKLPSAVQGRILKVS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08244 with Med12 domain of Kingdom Metazoa
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