<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08239

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIEMENHVFQKARNKDEYLGFVARLILHVREMNTKHKNQQNAAAAAAQQAQQEGVGNSNQQGGGGGGGGGGGGSGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMGGQMGGAGGNASNLLHSLRPQMQMGGMGGPMQANRVGMGPGPGNQMGGMMGPNQMQGPGAGMVGGMPGQMGVGIGPGGMSGGKIVGMGGQQQQQQQMAQLNAMQVNQMQQAQQQQQQQQQGGMSQPQQQQQGGLVQGQGGPVQQMGVGPGGPNQMNPMVMGQIQAQLQNQNAMGGQQMGTVGGTMNAANQMGPMVGSNAGMNPQAMGMAPNQVLRQQQQQQQQGMAQVQMGLGPGQMGQLNAGVQGGVGHGGPGPNMGQVQQQVVVQQQQQQQQHQQLQQHLQQHPQQHQQLQQQHQQQMQQQQQQQHQPQLQQQQMQQHQQHQQMQQHQQHQQQQQLAQQHAQHPQQHPQQQQLQQLQQHGQHPQQMQQQHQQQQQQQQVLLNAMGQGPVGTIGGGPIGGPGGPGVTMQQQAMQQQQHQQQQSSGMGPAGPNQMNPGVPMGPGGGGVMGTGPSQMLSAGAGGAAGQQGNFVSMGGNTMVRKPPDMMPGGNVFASGGVAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPQSHPGQMIPSPALIPSPNPHMGGVAQRSSIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKYRALTKYIEPLKRMIAKMENDDIDKIAKMKRLLEILSNPSVRIPLETLHKCEAALTSQLGSIRETPTNNPLVEAVSSSLQGASGNHTLQRTFRPCLDALFGPDIKNLPPPAKQSRLAQDDSSTGNGTGTGAGGTGGGAATTTTSTTTAAISTSSSSSSSSSSSNTAGSATTTNATVSSTAPQEIPHILQGEIARLDQKFKVSLDQCAISGTRTIRLICWLDDKNLPCVPPVAVTIPEDYPFTAPSCSLIEQEYNATPFLILVQKSLMARICKLPGLFTLSHLLDTWEMSVRQACSPNPTIVAPTGTSVLLGM
Length1044
PositionTail
OrganismAnopheles stephensi (Indo-Pakistan malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.02
Grand average of hydropathy-0.677
Instability index59.05
Isoelectric point9.20
Molecular weight109621.92
Publications
PubMed=25244985

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP08239
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     348.28|      45|      45|     404|     448|       1
---------------------------------------------------------------------------
  189-  245 (53.25/ 6.16)	GMMGPNQ..MQ.GPG.AGMvggmpgQMGVGIGPGGM......sggkivgmggQQQ......QQ..QQM..AQLNAMQ
  246-  295 (66.64/ 9.97)	VNQMQQA..QQQQQQ.QQ.......QGGMSQ.PQQQQQgglV..........QGQ......GGpvQQMgvGPGGPNQ
  353-  402 (66.40/ 9.90)	QVLRQQQ..QQQQQGmAQV......QMGL..GPGQMGQ...L..........NAGvqggvgHG..GPG..PNMGQVQ
  404-  448 (86.16/15.52)	QVVVQQQ..QQQQQH.QQL......QQHLQQHPQQHQQ...L..........QQQ......HQ..QQM..QQQQQQQ
  450-  494 (75.83/12.58)	QPQLQQQqmQQHQQH.QQM......QQH.QQH.QQQQQ...L..........AQQ......HA..QHP..QQHPQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     253.68|      41|      43|     509|     549|       2
---------------------------------------------------------------------------
  105-  149 (62.77/13.95)	GGGS.GMPDpinalQNLASQGTRPQMMGQMGV.GPGGPM.GGQMGGAG
  504-  544 (75.63/18.73)	QHPQ.QMQQ.....QHQQQQQQQQVLLNAMGQ.GPVGTIGGGPIGGPG
  545-  585 (70.13/16.68)	GPGV.TMQQ.....QAMQQQQHQQQQSSGMGPaGPNQMNPGVPM.GPG
  638-  674 (45.16/ 7.40)	GVAVrSVTP.....NNFLRQSPSPSV.....P.SPVGPGAHGPQSHPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.39|      31|      43|     777|     819|       7
---------------------------------------------------------------------------
  779-  819 (39.19/42.06)	TLHKCEAALtsqLG.SIRETPTnnP.....LVEAVSSslqgaSGNHT
  823-  859 (47.19/20.23)	TFRPCLDAL...FGpDIKNLPP..PakqsrLAQDDSS.....TGNGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.11|      16|      21|     740|     755|      16
---------------------------------------------------------------------------
  740-  755 (26.96/21.32)	IEPLKRMIAKMENDDI
  758-  773 (25.15/19.39)	IAKMKRLLEILSNPSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08239 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALTSQLGSIRETPTNNPLVEAVSSSLQGASGNHT
2) MAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIEMENHVFQ
3) NLPPPAKQSRLAQDDSSTGNGTGTGAGGTGGGAATTTTSTTTAAISTSSSSSSSSSSSNTAGSATTTNATVSSTAPQE
4) QHQQLQQHLQQHPQQHQQLQQQHQQQMQQQQQQQHQPQLQQQQMQQHQQHQQMQQHQQHQQQQQLAQQHAQHPQQHPQQQQLQQLQQHGQHPQQMQQQHQQQQQQQQVLLNAMGQGPVGTIGGGPIGGPGGPGVTMQQQAMQQQQHQQQQSSGMGPAGPNQMNPGVPMGPGGGGVMGTGPSQMLSAGAGGAAGQQGNFVSMGGNTMVRKPPDMMPGGNVFASGGVAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPQSHPGQMIPSPALIPSPNPHMGGVAQRSSIGQSPGGSLNTPGQPGGAVPSPLNPQDEQL
5) VREMNTKHKNQQNAAAAAAQQAQQEGVGNSNQQGGGGGGGGGGGGSGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMGGQMGGAGGNASNLLHSLRPQMQMGGMGGPMQANRVGMGPGPGNQMGGMMGPNQMQGPGAGMVGGMPGQMGVGIGPGGMSGGKIVGMGGQQQQQQQMAQLNAMQVNQMQQAQQQQQQQQQGGMSQPQQQQQGGLVQGQGGPVQQMGVGPGGPNQMNPMVMGQIQAQLQNQNAMGGQQMGTVGGTMNAANQMGPMVGSNAGMNPQAMGMAPNQVLRQQQQQQQQGMAQVQMGLGPGQMGQLNAGVQGGVGHGGPGPNMGQVQQQVVV
786
1
838
415
63
819
44
915
728
407










Molecular Recognition Features






MoRF SequenceStartStop




NANANA