<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08234

Description Uncharacterized protein
SequenceMTTAVMMDYEFKMKTQQERAKVEDLFEYEGCKVGRGTYGHVYKARRKEGNDSKDYALKQIEGTGLSMSACREIALLRELKHPNVINLIRVFLSHTDRKVWLLFDYAEHDLWHIIKFHRAAKATKKPVMVPKGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIRKMPEHHTLTKDFKRSNYASCSLVKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQDPYFSEDPMPTADVFAGCPIPYPKREFLTDEDQDDKGEKRQQQQQQQQQQQQQQQQQQQQQQNNQQQNNQQQNQQANVRTAQMQQGGGGGGAGGGTGAGQGGGGMDHNAKRVRLSGPNGHPNNSQGGMTQQEYHQQQQQQQNQQQQQQQNQMMFNSAQQGGFQQRY
Length503
PositionKinase
OrganismAnopheles stephensi (Indo-Pakistan malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.08
Grand average of hydropathy-0.900
Instability index53.42
Isoelectric point8.86
Molecular weight58008.85
Publications
PubMed=25244985

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08234
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     126.58|      15|      15|     378|     392|       1
---------------------------------------------------------------------------
  378-  392 (31.67/11.89)	QQQQQQ..QQQQQQQQQ
  394-  410 (24.78/ 7.81)	QQQQQQnnQQQNNQQQN
  411-  425 (22.09/ 6.22)	QQANVR..TAQMQQGGG
  460-  474 (24.06/ 7.38)	NSQGGM..TQQEYHQQQ
  475-  488 (23.98/ 7.34)	QQQQNQ..QQQQQQNQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.94|      16|      26|     245|     267|       3
---------------------------------------------------------------------------
  245-  262 (22.79/28.82)	EDIKtSNPYHHdQLDRIF
  274-  289 (31.16/13.06)	EDIR.KMPEHH.TLTKDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.67|      21|     374|      62|      83|       6
---------------------------------------------------------------------------
   62-   83 (33.63/27.16)	GTGLSMSACReIALLRELKHPN
  439-  459 (41.05/28.36)	GGGMDHNAKR.VRLSGPNGHPN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08234 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PNKRITSEQAMQDPYFSEDPMPTADVFAGCPIPYPKREFLTDEDQDDKGEKRQQQQQQQQQQQQQQQQQQQQQQNNQQQNNQQQNQQANVRTAQMQQGGGGGGAGGGTGAGQGGGGMDHNAKRVRLSGPNGHPNNSQGGMTQQEYHQQQQQQQNQQQQQQQNQMMFNSAQQGGFQQRY
326
503










Molecular Recognition Features






MoRF SequenceStartStop




1) MDHNAKRVRLSGP
2) QQEYHQQQ
442
467
454
474