<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08225

Description Uncharacterized protein
SequenceMSSSGTAAVSGGSLPALLMANGGGGGIGGVGAGKGIGKPDTKPPGAGNTTGGTGTTGKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFPEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPAGGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHTLYTLSLQHFPDVHSQLLKAPLGVVQKRRGGHPMRLTYFVAPYELLDLGTRTMNVLSVDLIAKERIGCSVAVVLEASSANKLQIQPLLVGNGSGGAATLSGTGLPVYAPIEKHNSTSLPATFVLRLSKPMPINGAMMRAIRGIVGGSEQQAVGDGTASASSTSSNSGLPTSLLGLIAHHASGGSVTDLAKGLLVSLPDQYHCYYLTDNPLLRGVMVSSIPFTEPQHVPKILTYLRQQAIFNQLLSSCIRSNTSPGGGGRPSALQLLLDGGAHPIENGSTGGLLVFEVSALSCQNITVSLIHPYEESLATVEFDLQNIANIVVRIYCSEGETSDEHTVDRLSAVLQRCMSIPVTLRALMKHWEEEHEQKFKPNVLGSAAITSSGGGGGPGGGIGGAGGGGGDGSGTPGGGGGGGVPGSGEDGSMNGFNLSSLGGSASSVDGGGVGAGGSAATNGTSAQQTSNQRGLMNGEGSLGLDFCDMLTERNGNGLGALGSNGRLAGGLGTREPPEPLAGGAAKKRRMEDFCKSPKSDSNLSVGGGGSEGGGVEKANVTGTVASTTITTTVTSQDVATVTVNSEQRVQAGGAKEEDTGGLPLFGQTAPMGGADAKGSSLGGTITNTILSAKNEPLPSVLPSDDGDEPVKMPLQSSSSSSLSSLSSSGFSLTGGAPSGEPDRPCPGTLLLESLESATLELDSVKKSSGQSAKRRRSSSSSSSSSSSSSSSSSSSSSTSAASDEVEESVDLVEAEMSSFFAEVNNTQPKAVATGVAAKGSYGAPSGKPALGTVSPISGKVVSPASNSGLEKPIVPLGRDSSGLEIIPLTTGSATIPATITNTPITTASQTLANSVSSASLTTTSAASKKSSSSSSSSSGSHPKGGSTESSERSSSSKSEKKKKRKVDDSGHLAMGPPNKLPFKSGESSPHRSGLGSSSSSSNKASPKRASPVHHSSPKHTGSGALGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGSKSSDASGGSGGGGGGAGGVSLSSTGGSSKERDKERSEKKALQFSATSASAGSSLTGSSSGGRSKSSGLKLKQLDLAAAGSSLTISMGESGSSSPVAPMIDLTGSGSVQGASLGSLGLSGSGLTTASSMLQALQAAKNRKAPSSAGGTGLGGSLSAVIDKLKSAQSTDDEAAVLVLPEMTITQQTTSTPMTAGGTGAGLNIGGFGSMGAGAALKDPSKMGSNLLSATGSALLGNCVSSTAGIGAALTQSSSMTSAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSSSKSSSSTNSSSSGGSKSGGSNKSGLKSGVSSGPASSKQQQQQNHTTSFSGAFPSSTKTPHYTSSSSGSSKTPFQKSNSFGSLGGGGTGMKASSKVSSPKSTSNPASSSYSSKEKGGAGRSKSSSASSLTGAMLSGASGGGTGSSALVNPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNSNSTASGGAGQNESSESGKSAKDSTVRKQKPQLPITSSAQSSVGSAALRTFSTSPSGDASARLLSDLLGAAAKSGSKAGSGSSVASVDGGGAALHPLLPNIVQKMFGSDGSLQSKSNSSDGSMFPSAGRASPGMLSGGGSASRDGFRSGTGSAPGTPTTAGSMVLPPFPSPVSGGASNDGDVGSSSAGSLMRPPSRPSSTISNHSHSSQDGIGGGGGGDVCAPPVATSMAASMMMMSAMSGAAGGQSPVLDSTSTQQLIAALAAKTGAAGAGGGVLPPPTSLLNNHASHLHHHSNHVNNHVVGGAGSVHLVKSPAPSPLPFTSPRSNASSTHGGGPGGVGLDDELMDEALIGIGSK
Length2076
PositionMiddle
OrganismAnopheles stephensi (Indo-Pakistan malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.271
Instability index51.59
Isoelectric point9.15
Molecular weight206047.60
Publications
PubMed=25244985

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08225
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|    1160.08|     150|     151|     892|    1041|       1
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  753-  921 (138.67/25.01)	..................L.........A..GG...AAKK..RRMEDFCKSPKSD........SNLSVGGGGSEGGG...VEKA.NVTGTVASTTITTTVTSQD.......VATVTvnseqRVQAG.GAKEEDTGGlPLFGQTAPM.........G.GAD..AK.GSSLGGtitntilsakneplpsvlpsddgdepvkmplqsssSSSLS.SL....S...SSGF...SLTGGAP......SGEPDRPCPGT
  922- 1071 (191.50/38.09)	LLLESL...ES.....ATLEL.DSVKKSS..GQ...SAKR..RRSSSSSSSSSSS........SSSSSSSSSSTSAASDEVEESVDLVEAEMSSFFAEVNNTQP.......KAVAT.....GVAAK.GSYGAPSGK.PALGTVSPI.........S.GKV..VS.PASNSG..................................lEKPIV.PL....G.rdSSGLeiiPLTTGSA......T......IPAT
 1072- 1228 (143.13/26.11)	ITNTPI...TT.....ASQTLaNSVSSASltTT...SAAS..KKSSSSSSSSSGShpkggsteSSERSSSSKSEKKKKRKVDDSGHLAMGPPNKLPFKSGESSP.......H..RS.....GL....GSSSSSSNK.ASPKRASPVhhsspkhtgS.GALgfHS.PKHGSS...................................VSPKH.PL....H...SGGS...STGGGKP......S..........
 1229- 1358 (119.79/20.34)	..MSAL...KS.....AA.........AS..GS...SPGS..KSSDASGGSGGGG........GGAGGVSLSSTGGSSKERDK..ERSEKKALQFSA................................TSASAGS.SLTGSSS...........G.GR.......SKSSG........................lklkqldlaaaGSSLTiSM....G...ESGS...S.SPVAPmidltgSGSVQGASLGS
 1359- 1500 (130.51/22.99)	L...GL...SG.....SGLTT.ASSMLQA..LQ...AAKN..RKAPSSAGGTGLG........GSLSAVIDKLKSAQSTDDEAAV.LVLPEM.TITQQTTSTPM.......TAGGT.....GAGLNiGGFGSMGAG.AALKDPSKM.........G.SNL..LS..ATGSA.......................llgncvsstagiGAALT.QS....S...S.......MT.SAP......S..........
 1501- 1621 (115.26/19.22)	.LTAAL...TS.....GKASE.YMVKPSS..DGiklTIQN..KKGSSSKSSSSTN........SSSSGGSKSGGSNKS...G.....LKSGVSSGPASSKQQQQ.......QNHTT.....SFS...GAF..............PS.........S.TK....T.P....H...............................ytssSSGSS.KT....PfqkSNSF...GSLGGGG......TG.........
 1622- 1739 (103.56/16.32)	....................M....KASS..KV...SSPK..STSNPASSSYSSK........EKGGAGRSKS.SSASS.......LTGAMLS..................................GASGGGTGS.SAL..VNPI.........SiMKM..LGyPTGSMG.....................nmegfaksldtkfqIPKLS.AR....S...NSNS...TASGGA........GQNESSESGK
 1740- 1882 (146.21/26.88)	SAKDSTvrkQK.....PQLPI.TSSAQSS.vGS...AALR..TFSTSPSGDASAR........LLSDLLGAAAKSGSKAGSGSSV....ASVDGGGAALHPLLP.......NIVQK.....MFGSD.GSLQSKSNS..SDGSMFPS.........A.GR...AS.PGMLSG...........................................ggsaS...RDGF..rSGTGSAP.......GTP..TTAGS
 1883- 1991 (71.46/ 8.37)	MVLPPF...PSpvsggASNDG.D.VGSSS..AG...SLMRppSRPSSTISNHSHS........SQDGIGGGGGGDVCAPPVATSMAASMMMMSAMSGAAGGQSPvldststQQLIA.....ALAAKtGAAGA.........................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.78|      33|     613|       5|      64|       2
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   23-   33 (12.06/ 8.16)	................................GGGGI..............GGVGAG
   34-   64 (17.85/ 7.65)	KGIGkpdTKPPGAGnttGGTGTTGKvllGGD..........................
  642-  689 (49.87/11.36)	GGDG...SGTPGGG...GGGGVPGS...GEDgSMNGFnlsslggsassvdgGGVGAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.46|      40|     126|     461|     503|       3
---------------------------------------------------------------------------
  461-  503 (69.73/47.46)	SIPFTEPQHVPKILTYLRQQAIFNQLLSSCIrsnTSPGGGGRP
  592-  631 (74.72/43.45)	SIPVTLRALMKHWEEEHEQKFKPNVLGSAAI...TSSGGGGGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     277.95|      88|     122|     242|     333|       4
---------------------------------------------------------------------------
  242-  333 (139.03/79.19)	LHTLYTLSLQHFPDVHSQLLKAPLGVV....QKRRGGHPMRLTYFVA....PYELLDLGTRTMNVLSVDLIAKeriGCSVAVVlEASSANKLQIQPLLVG
  361-  456 (138.93/70.05)	LPATFVLRLSKPMPINGAMMRAIRGIVggseQQAVGDGTASASSTSSnsglPTSLLGLIAHHASGGSVTDLAK...GLLVSLP.DQYHCYYLTDNPLLRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.57|      22|     127|     731|     752|       5
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  706-  730 (31.33/12.70)	RGLMNGEGSLGldfCDMLTERNGNG
  731-  752 (36.24/16.21)	LGALGSNGRLA...GGLGTREPPEP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.03|      28|      34|    1993|    2026|       8
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 1993- 2026 (44.34/30.19)	GGVL...PPPTSLlnnhaSHLHHHSNHVNNHvVGGAG
 2027- 2057 (48.69/20.50)	SVHLvksPAPSPL.....PFTSPRSNASSTH.GGGPG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08225 with Med1 domain of Kingdom Metazoa
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