<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08217

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSADLRIVKLFEEVVEDKNIVPNFDEEEQRKKTEEGYKKIGTLFGAMAPESKEAAIRNYLGYVASVNHQNRVHNYLQVMNRMVALNIIPAKLLCDQLMCSEKLVYKNPCFWIEAFRLIRKVIGGVDYKGVREIMKCCKEKALSFPASVSVNILPQLLELVELIEHIFNRNACLLPAYFIINEIKKTDYQNMHWRVSNLTANFIEEFVSVAQMLSIIGHSAMLPIVEHSSYADNLIIPWKLDPDTLKLSLRGNLPYDEELLQPQARLLRFVLQQPYSRDMVCSMLNFQKQQKQKCAALEEQLVWLVLNAMECSEKEAAQGGQGAAGGTGMNEHEGDQSHTQWIWLHLSSQLIYFVLFQFATFQNIVNTLHEKLAVRNLRRGRDHLMWVFLQYISGSIQKHSILNFLPILKLYDILYPEKEPLPVPDNNNPNCTHQMAPTCIWIHLMKRAQTENYNINRPVPIALRLHFEYLQHLAMPSNNPTLFMGSEYRFALLCNAYSTQTDYFSRPMQALIDTILGNSKNPQANMVGGGQPLPTAPLSMRVLDSLTIHSKMSLIHSIVMHMIKQAQNKSSIPNGNNMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSQAWGILYTLLEMFSYRMHHIHSHYRVQLLTHLHSLASVPHTNQMQLHSCVESTALRLIIGLGSVEVQAQLSRYVSEPKPPGNIVSGESEELNRALILTLARSMHITGTGNDPQSSAWCKDLLQNIMVNTPHAWPQHTLYCFPPVLNEFFMQHNIPKESKQLLKKTVDEEYRNWASMTNENDIIAHFGMTVNPPLFLCLVFKMIIETDGISPVAYKILERIGARALSTHLRKMCDYLLFEVANSGGGAHVNKCVDTINDMIWKYNIITIDRLVLCLILRTLDGNEAQVSFYIIQLLLLKTTEFRNRVQEFITINSPEHWKQNNWHERHLAFHQKFPEKFAPDESVSHPSLPVYFGNVCLRFLPVLDIIVHRYLEVPTQLSKTLDVILDHLGSLYKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGTVVGSLKDVRPENWALTEAYQAYMMTKESDNVNWVPELSYYINLVPMDGKNIFAGTDWRFNEFPNPPAHALYVTCVELLGLPVGPSVVANSIIDVLVKGYPVVPNGVIHNWANTIGLIMAALPEAYWSVIYERMQEALSSKAMKEWTYRQSPFDMFNFKIVKEAMLDRSYVTVLAIVHSIFHHFGIGQLATITDSIKEKLKPLVHTEYQLIYLCHVVGPFLHRLSIERARAVADITLMLYELLEQVDKAQPAQPLRYMDPICDLLYHIKYMFVGDTMKTELEAIIRRLRPALQMRLRFITRLNVEEIGVDQNAAAAGGGAGAGGAATATGQGVAGAGPGVGPSPGGVAAGAPGATQGVVASGQAVPGTAAGPQQPQQVVGVVGNPNVALQQQLQQQQMGQGIQSHH
Length1446
PositionTail
OrganismAnopheles quadriannulatus (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.09
Grand average of hydropathy-0.086
Instability index45.37
Isoelectric point7.33
Molecular weight163717.80
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08217
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.05|      18|      18|    1351|    1368|       1
---------------------------------------------------------------------------
 1351- 1368 (34.25/19.43)	QNAAAAGGGAG..AGG.AATA
 1371- 1391 (25.79/12.90)	QGVAGAGPGVGpsPGGvAAGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.01|      15|      17|    1116|    1130|       2
---------------------------------------------------------------------------
 1116- 1130 (26.27/14.96)	VELLGLPVGPS.VVAN
 1135- 1150 (23.74/12.78)	VLVKGYPVVPNgVIHN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.30|      14|      18|    1392|    1409|       3
---------------------------------------------------------------------------
 1392- 1409 (18.00/19.53)	PGATQ...GVVasGQavPGTA
 1412- 1428 (23.30/11.33)	PQQPQqvvGVV..GN..PNVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     796.04|     266|     320|     468|     786|       4
---------------------------------------------------------------------------
  410-  523 (88.43/40.69)	............................................................................................................................................................................................................................................LYDILY......PEKEP......LPvPDNNNPNCTHQMAPTCiwIHLMKRAQTE..NYNiNrpvpialrlhfEYLQHLA.MPSNNPTLFMGSEYRFALLCNA.....YS..TQTDYFSRPMQALIDTILGNSKNPQ
  524-  842 (369.42/387.08)	ANmVGGGQPLPtaplsmRVLDslTIHS.....KMSLIHSIVMHMIKQaqnksSIpNGNNMAPALVETYSRLLVYTEIESlGIKGFLGQLLPQVFKSQAWgilytllemfsyrmHHIHSHYRVQLLTHLHSLASVPHTNqmqLHSCVESTALRL.....IIGLGSVEVQAQLSR............YVSEPKPpgnivsgeseelnralILTLARSMHITGT..GNDPQssaWCKDLLQNIMVN....TPHAWPQHTLYcFP.PVLNEFFMQHNIPKES..KQLLKKTVDE..EYR.N...wasmtnenDIIAHFG.M.TVNPPLF.........LCLV.....FKmiIETDGISPVAYKILERIGARALSTH
  855- 1114 (338.19/241.78)	AN.SGGGAHVN......KCVD..TINDmiwkyNIITIDRLVLCLILR.....TL.DGNEAQVSFYIIQLLLLKTTEFRN.RVQEFITINSPEHWKQNNW..............HERHLAFHQKFPEKFAPDESVSHPS...LPVYFGNVCLRFlpvldIIVHRYLEVPTQLSKtldvildhlgslYKFHDRP................ITYLYNTLHYYERklRDRPQ...LKKRLVGTVVGSlkdvRPENWALTEAY.......QAYMM....TKES..DNV..NWVPElsYYI.N..................lVPMDGKNIFAGTDWRFNEFPNPpahalYV..T........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.96|      15|      15|      45|      59|       5
---------------------------------------------------------------------------
   45-   59 (25.54/18.54)	GAMAPESKEAAIRNY
   61-   75 (27.41/20.52)	GYVASVNHQNRVHNY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.06|      14|      44|     330|     344|       6
---------------------------------------------------------------------------
  330-  344 (24.75/17.01)	NEHEGdQSHTQWIWL
  376-  389 (27.31/14.06)	NLRRG.RDHLMWVFL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08217 with Med23 domain of Kingdom Metazoa
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