<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08215

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKHGFATEHKLSEEFGTARNCNVSASKVGAYFNAILAKKEELMTLPDSGRKKQQINPKDNFWPVTARNKTTLDTWFKDLAGTKPLSSLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFMKDLIPKLHEHYHQGPLQEKPSSGGAGSSGGLGSGASGLGLSSGAGGTNAVTIPPPLSSPAGSMHSPAGANPVIGGSMHAQQQQQQQQQQQQPISPQEEQRIAQKQWNYSTQLCKYMYEEGLLDKQEFLNWIIDLLEKMKSSPNADDGLLRIYLPLAMQYLYDLVQSERFCRRLAYAVSKKLAQLINQMAESHNINLSSPEPQDASGKQPSIEAPDSKSEKQNDKPSKEGTAGTVAQPADTKPPKVNPYEMIFTEYLQCSHHRDVILQLSSILQVITLECPTALVWCGVGETRSSSVLSGSPLDHLPVAPSALPIPTRYEKSNADIRRQLFEAEESIKVRSRHAESRWCIDKWQTAAGNASLKILATLDALDGHCFDRMDSNNSLDSLYSKIFPPFQVQPLKPAESASAAGGSGGSGTGNTPSGLAAVDGKDAATKQFEYNVEQDSSIVKILCEWAVSWQRWGEHRAMVVAWLLDKRQNEVLTALENDSYTNNLNNSDDKDSVLSGSGLNGGQPVFQHILMNFLDHDAPVLDEAGSPQNKSQFTNLVHLFSELIRHDVFSHDAYMCCLISRGDLLTGAGGMLSLDSQGICNAGLGTGPISNKPATSSSPNGGGGVEDDVLQTDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEHAAPSVTGLGKAESSSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRSEFNFESTSNKCQAMSYFDQHVVTWQCAVQVQEMLNAFAIGNSNYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILRELPEVELQLIGKSSMALVRSYTTSLSLYVVGVLRRYHCCLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSACSSLKARPQQEPFHNAYPKIKQALYTPLQPTPSAHTYNPQFMLDIITNPRRGGKIESGWARQLNESASNRYSFVCNAVVAVTRDIDNDCLNDIAAMCAELTACCNSLSTEWLGVLIALCGSNRDAGYYVDVLTQVDVQNTNIHNALSVFTSILVARHCFSLENFVAHVALPSLVQACKGRGETTPEIEAGARLSCHLLLRLFKTIECPQPGLYSVSTSPNPITVGNAHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATAHKVSSIFGSGKRSGLNTPVHPGSTPKSMAGSGDLSHILGTSDLSILGNPDESMLDVSMIELGELSPTASARLYSSRQQNSHLNQDNATSLSDFAQHVLRQICSQEWVLERCLQHAEELCQHGMLIDNLLTAKQAQRLLHMICYPEHESNLIAELEQKAIIVRILENLEQWSLRISWLDLQLMFKQTNCSSPDLSNWLDMVARAAIDVFRVNEFILNSPDVKQEKVKPSTWLVAPLVSKLPSAVQGRILKVSGQVLESTSMFSKHKDGNGGNNSSSNNSHNHGANSNSSVSSNGSTFGSKQSAQLNHQPFLGLVLTCLKGQDEQKEGLLQSLYSQLSQFLQNRDQSLETIGGIEDPCGFEKMLDALQLRYSLVGGLFDAIMKNATSTTDWAILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSQTERDENKKLYTNLMKKLRKELGDKNGPSIKYVRQLLPLAKQTCEVLTCDSAGSSTDAKGNKIAIDSIEKKNGLRLGDKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLFKPSSYYYEPLPLPPEEVDPLPDKLKDDMKADTPSSDQSPAPSTGSKKSKTTTRKRKTKATAAAQVQQSQPQQPIMPAIVPQPAAGPQQMQQMQQQQQQQQQQQQQQQQHQQHQQQQQQQQMQQQQTLQQQQHLQQQQQQLHLQQQQAQQQQQLQQQQQLQQLQQQQQQQLQQQQQQQNQMMMQQQQQPNIPQQQQSALQQQQLGSQQGQQQQQQVTMTPQQTLQQMQNNSMGGMQMGGPMSSMNQQHMQQQYGQANPAQLVGQGNMGGMQTGMGGLGAGMGGGMMNQQQQQQQQQQQQPPQQQQPQQAQQAQQAQQAQQQQPQGNPNMGFVGNVNPMAQLAQQQGGNQQWGGYGSLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQSQVQQQQQTPQQGQQASQQQGPQQGPQQGAQQGPQTQQQLQQQQQQQQMFYSGMGQATMNRFDRPQLNTNSKQALSNMLRSKLPINAGHPASFMQQQQQQAQQQQAQRNPQQPFLRGPLRAGMPGNPIVGTQAGMGPMNPAMAGGTAGIGTAGGGAVMGAQGMGAGGMMGAQQTAQGQQGAGGIMNQTTPAMMGTTGGSIMSQSGGSMIQTGMMNPQQNPALVGQGMGGSGGLGGASGMAGNSGMGASAGGMGGTSGGGMVTSGGMVTGGMGSTGIGNTAPMGAGGQGGGMGGNAGMPNAAGMGNPAMGNPGMGMQNMQQSGNMQGGGMFQGQNVPYQNVNQNYPNYGNQGMGQQSGQGGGMMGNFNPMAQQQRNTQAEFLAQQRAAMAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGGNMPQNQQQQFQQQRMRLIMQQHSGMGQGGNAQGMMQNQGQGMSTQQTPNLVAQLQRQMPNQNSMMGQQYPHQPPQY
Length2831
PositionKinase
OrganismAnopheles quadriannulatus (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.635
Instability index56.77
Isoelectric point6.89
Molecular weight309722.57
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08215
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     174.04|      17|      17|    2282|    2298|       1
---------------------------------------------------------------------------
 2023- 2041 (32.27/ 6.27)	QQQQQQQQQqqHQQHQQQQ
 2080- 2096 (32.73/ 6.47)	QQQQLQQLQ..QQQQQQLQ
 2290- 2307 (35.55/ 7.66)	QQQQQQQQQ.qQQQQQQQQ
 2308- 2324 (39.95/ 9.53)	QQQQQQQQQ..QQQQQQQQ
 2359- 2375 (33.54/ 6.81)	QGPQTQQQL..QQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            12|     760.87|      61|      61|    2539|    2599|       2
---------------------------------------------------------------------------
 1990- 2062 (55.11/ 8.85)	....VQQ...S.....QPQQPI.........MPaivP.Q.................PA.AGPQQMQQMQQQQ.......QqqqqqqqqqQQhqqhqqqqQQQQMQ.......QQ...................................QTL.....QQQQhlqQQQ
 2113- 2146 (48.29/ 6.89)	PNI...P...Q.....QQQSALQ.....QQQLG...S.Q.................QG.........................................QQQQQQ.......V............................................TMTP...QQ.
 2147- 2184 (53.47/ 8.38)	.TL.QQ..........MQNNSM.......GGMQ...M.G.................GP.M..S..........................SM........NQQHMQ.......QQ.....................................Y....GQANP...AQ.
 2185- 2246 (79.42/15.82)	..L.VGQ...GnmggmQTGMGGLG.....AGM....G.G.................GM.MNQQQQQQQQQQQ.......Q.........PP........QQQQPQ.......QA...................................QQAQ..qAQQAQ...QQQ
 2247- 2336 (57.72/ 9.60)	P.....Q...G........NPNMG.......FV...G.N................vNP.MAQLAQQQGGNQQ...wggyG.........SL........QQQQQQ.......QQqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqQTQS...QVQQQ...QQT
 2392- 2439 (50.29/ 7.47)	PQLnTNS...K.....QALSNML.....RSKLP...I.N.................AG.HPAS..........................FM........QQQQQQ.......AQ...................................Q....qqAQRNP...QQ.
 2440- 2486 (52.83/ 8.20)	PFL.RGPlraG.....MPGNPIVGT...QAGMG...PmN.................PA.MA......GGTAG.......I.........G.........TAGGGA.......V......................................MG..............
 2488- 2546 (66.11/12.00)	......Q...G.....MGAGGMMGAqqtAQGQQ...G.A.................GGiMNQTTPAMMGTTG.......G.........SI........MSQSG.............................................GSMI.qtGMMNP...QQN
 2547- 2605 (92.15/19.47)	PAL.VGQ...G.....MGGSGGLGG...ASGMA...G.N.................SG.MGASAGGMGGTSG.......G.........GM........VTSGGM.......VT...................................GGMG.stGI.......GN
 2606- 2666 (92.44/19.56)	TAP.MGA...G......GQGGGMGG...NAGMP...N.A.................AG.MGNPAMGNPGMGM.......Q.........NM........QQSGNM.......QG...................................GGMF..qGQNVP...YQN
 2672- 2744 (55.11/ 8.85)	PNY.GNQ...G.....MGQQSGQGG.....GMM...G.N................fNP.M...AQQQRNTQAeflaqqrA.........AM........AAGRGQygqhapnVT..................................mGNMGvnqGAVPP...Y..
 2745- 2802 (57.92/ 9.66)	PR...Q...........GGKPGVGG.....NMP...Q.NqqqqfqqqrmrlimqqhSG.M.....GQGGNAQ.......G.........MM........QNQG....................................................qG.MST...QQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.56|      15|      15|    1628|    1642|       3
---------------------------------------------------------------------------
 1628- 1642 (26.97/12.28)	SKHKDGNGGNNSSSN
 1644- 1658 (25.59/11.29)	SHNHGANSNSSVSSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.58|      18|      21|    1356|    1376|       4
---------------------------------------------------------------------------
 1357- 1376 (26.57/22.83)	GI.LVVGDATAHKvsSIFGSG
 1380- 1398 (28.02/11.91)	GLnTPVHPGSTPK..SMAGSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.78|      13|      24|    1705|    1720|       6
---------------------------------------------------------------------------
 1705- 1720 (15.20/19.48)	LQNRdQSLetIGGIED
 1731- 1743 (24.57/14.58)	LQLR.YSL..VGGLFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.26|      28|      28|    1750|    1777|       7
---------------------------------------------------------------------------
 1750- 1777 (46.31/33.69)	TSTTDW..AILFAQLISQGVIDLSNNSELF
 1778- 1807 (40.95/28.76)	TTTLDMlaTLIHSTLVSDSQTERDENKKLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.66|      17|      19|    1856|    1872|      12
---------------------------------------------------------------------------
 1856- 1872 (28.48/22.28)	GNKIAI...DSIE.KKNGLRL
 1873- 1893 (21.18/14.09)	GDKQRVsvwDLLEgHKNPAPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08215 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AQGMGAGGMMGAQQTAQGQQGAGGIMNQTTPAMMGTTGGSIMSQSGGSMIQTGMMNPQQNPALVGQGMGGS
2) DLDKLLQHIKEDQQNSMDAPDSPKDPEHAAPSVTGL
3) GMGASAGGMGGTSGGGMVTSGGMVTGGMGSTGIGNTAPMGAGGQGGGMGGNAGMPNAAGMGNPAMGNPGMGMQNMQQSGNMQGGGMFQGQNVPYQNVNQNYPNYGNQGMGQQSGQGGGMMGNFNPMAQQQRNTQAEFLAQQRAAMAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGGNMPQNQQQQFQQQRMRLIMQQHSGMGQGGNAQGMMQNQGQGMSTQQTPNLVAQLQRQMPNQNSMMGQQYPHQPPQY
4) GQQQQQQVTMTPQQTLQQMQNNSMGGMQMGGPMSSMNQQHMQQQYGQANPAQLVGQGNMGGMQTGMGGLGAGMGGGMMNQQQQQQQQQQQQPPQQQQPQQAQQAQQAQQAQQQQPQGNPNMGFVGNVNPMAQLAQQQGGNQQWGGYGSL
5) HEHYHQGPLQEKPSSGGAGSSGGLGSGASGLGL
6) HNINLSSPEPQDASGKQPSIEAPDSKSEKQNDKPSKEGTAGTVAQPADT
7) LPLPPEEVDPLPDKLKDDMKADTPSSDQSPAPSTGSKKSKTTTRKRKTKATAAAQVQQSQPQQPIMPAIVPQPAAGPQQMQQMQQQQQQQQQQQQQQQQHQQHQQQQQQQQMQ
8) MFSKHKDGNGGNNSSSNNSHNHGANSNSSVSSNGSTFG
9) MNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKH
10) SGAGGTNAVTIPPPLSSPAGSMHSPAGANPVIGGSMHAQQQQQQQQQQQQPISPQEEQRI
11) TQSQVQQQQQTPQQGQQASQQQGPQQGPQQGAQQGPQTQQQLQQQQQQQQMFYSGMGQATMNRFDRPQLNTNSKQALSNMLRSKLPINAGHPASFMQQQQQQAQQQQAQRNPQQPFLRGPLRAGMPGNPIVGTQAGMGPMNPAMAGGTAGIGTAGGGA
2487
824
2571
2133
194
378
1935
1626
1
228
2326
2557
859
2831
2281
226
426
2047
1663
35
287
2483










Molecular Recognition Features






MoRF SequenceStartStop




1) GGYGSLQQ
2) IMPAIV
3) MNMRPLKRPRLGPPDVY
4) YYEPL
2276
1999
1
1931
2283
2004
17
1935