<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08213

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMNPGRLGLAPLLQENPLWISWHDSNWIPVLNPGNVMDYFSEKSNPFYDRTCNNEIVRMQRQSLELLNNMTGVEYIPLHVQDPILYVIRKQHRHSPTEATPMADYYIIAGTVYQAPDLASVFNSRILSTVHHLQTAFDEASSYSRYHPSKGYSWDFSSNKASTHAMAEQVAEKTKTQTKKEAPVKEEPSSIFQRQRVDMLLGDLLRKFPLPLPQMTNNPTGGNPSDAGNASNNHGGAAGDSDHVGADATLIKQEPTEGGVGRGGNNDVPPEKKMKL
Length275
PositionHead
OrganismAnopheles quadriannulatus (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.08
Grand average of hydropathy-0.651
Instability index44.10
Isoelectric point6.20
Molecular weight30583.91
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08213
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.88|      27|      65|      10|      39|       1
---------------------------------------------------------------------------
   19-   47 (46.20/21.53)	ISWHDSNWIPV.LNPGNVMDYF.seKSNP.FY
   55-   85 (32.44/20.58)	IVRMQRQSLEL.LNNMTGVEYIplhVQDPiLY
   86-  105 (21.24/ 6.27)	VIRKQHRHSPTeATP..MADYY..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.49|      13|      33|     216|     228|       2
---------------------------------------------------------------------------
  216-  228 (25.55/16.96)	NNPTGGNPSDAGN
  252-  264 (24.93/16.36)	QEPTEGGVGRGGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.79|      14|      32|     121|     135|       3
---------------------------------------------------------------------------
  121-  135 (21.43/21.87)	FNSRILSTvHHL..QTA
  155-  170 (20.36/14.65)	FSSNKAST.HAMaeQVA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08213 with Med6 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FPLPLPQMTNNPTGGNPSDAGNASNNHGGAAGDSDHVGADATLIKQEPTEGGVGRGGNNDVPPEKKMKL
2) THAMAEQVAEKTKTQTKKEAPVKEEPSSIFQ
207
162
275
192










Molecular Recognition Features






MoRF SequenceStartStop




1) HVGADATLIKQEPTEGGVG
2) PPEKKMKL
242
268
260
275