<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08206

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIEMENHVFHKARNKDEYLGFVARLILHMGGAGQASNLLHSLRPQMQMGGMGGPMQGNRVGMGPGNQMGGMMGGPNQMQGPGAGMVGGMPGQMGVGMGPGGMSGGKIVGMGGQQQQMAQLNAMQVNQMQQAQQQQQQQQQQQGGMSQPQQQQQQQQQQQGGIAQGQGGPVQQMGVGPGGPNQMNPMVMGQIQAQLQNQNAMGGQQMGTVGGTMNAGNQMGQMVGANAGMNPQAMGMASNQVVRQQQLQQQGMGQVQMGLGPGQMGQLSAGVQGGQQQMQQHQQHQQMQQHQQHQQHQQLAQQHGQHPQQHPQQQQQQLQQLQQHGHPQIQQQQQQQHQQQQVLLNAMGQGPGVGPGVGSIGGPIGGPGGPGVTLQQQAMQQQQQAGGMGPGAGPNQMNPGVAMGPGGVVGPAGGGGVMGPGPNQMLGAGGAGGPGAGQQGNFVGMGANAMVRKPPEMMPGGNVYPGSGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPPSHPGQMIPSPALIPSPNPHMGGVAQRSTIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKYRALTKYIEPLKRMIAKMENDDIDKIAKMKRLLEILSNPSVRIPLETLHKCEAALTSQLGSIRETPTNNPLVEAVSSSLQAATGNHTLQRTFRPCLEALFGPDIKNLPPPAKQSRLALDDTGAAGGTGGGVTTGGATTTTTSTTTAAATTGSASSTTSTAASSTTAPQEIPHILQGEIARLDQKFKVSLDQCAISGTRTIKLICWLDDKNLPCVPPVAVTIPEDYPSTAPSCSLIEQEYNATPFLILVQKSLMARICKLPGLFTLSHLLDTWEMSVRQACSPNPTIVAPTGTSVLLGM
Length894
PositionTail
OrganismAnopheles quadriannulatus (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.02
Grand average of hydropathy-0.536
Instability index52.55
Isoelectric point9.12
Molecular weight93185.51
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08206
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     716.37|     160|     179|      81|     258|       1
---------------------------------------------------------------------------
   81-  245 (287.16/56.76)	.............QMGGMG...GPMQGNR.VGMGPGNQM.....GGMMG.GP....NQMQGPGAGMVGGMPGQMG..VGMG........PGGMSGGKIV.GMGGQQQQMAQLNamQVNQMQQAQQQQQQQQ..QQQGGMSQ..PQQQQQ.........Q.QQQQQGG...IAQ....GQ..GGPVQQ.......MGVGPGG..PNQMNPMVmGQIqaqlqnqnamGGqQMGTVGG
  246-  403 (232.65/38.50)	TMnaGNQMGQM..............VGAN.AGMNP..QA.....MGMAS.NQvvrqQQLQQQGMG.......QVQ..MGLG........PGQM.GQLSA.GVQGGQQQMQQHQ..QHQQMQQHQQHQQHQQlaQQHGQHPQqhPQQQQQ.........QlQQLQQHGhpqIQQ....QQ..QQQHQQqqvllnaMGQGPG......VGPGV.GSI..........GG.PIGGPGG
  407-  587 (196.56/30.43)	TL..QQQAMQQqqQAGGMGpgaGPNQMNPgVAMGPGGVVgpaggGGVMGpGP....NQMLGAG.GAGGPGAGQQGnfVGMGanamvrkpPEMMPGGNVYpGSGGAVRSVTP.N....NFLRQSPSPSVPSP..VGPGAHGP..PSHPGQmipspalipS.PNPHMGG...VAQrstiGQspGGSLNT.......PG.QPGGavPSPLNP..........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.57|      11|      15|     728|     739|       2
---------------------------------------------------------------------------
  728-  739 (15.92/11.37)	TTGGAtTTTTST
  745-  755 (19.65/ 9.10)	TTGSA.SSTTST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.36|      17|      17|     664|     680|       3
---------------------------------------------------------------------------
  650-  669 (20.58/ 8.90)	ALTSqlgSIRETPTNNPLVE
  670-  686 (26.77/13.52)	AVSS...SLQAATGNHTLQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.11|      16|      17|     604|     619|       4
---------------------------------------------------------------------------
  604-  619 (26.96/20.90)	IEPLKRMIAKMENDDI
  622-  637 (25.15/19.01)	IAKMKRLLEILSNPSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08206 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AQLNAMQVNQMQQAQQQQQQQQQQQGGMSQPQQQQQQQQQQQGGIAQGQGGPVQQMGVGPGGPNQMNPMVMGQIQAQLQNQNAMGGQQMGTVGGTMNAGNQMGQMVGANAGMNPQAMGMASNQVVRQQQLQQQGMGQVQMGLGPGQMGQLSAGVQGGQQQMQQHQQHQQMQQHQQHQQHQQLAQQHGQHPQQHPQQQQQQLQQLQQHGHPQIQQQQQQQHQQQQVLLNAMGQGPGVGPGVGSIGGPIGGPGGPGVTLQQQAMQQQQQAGGMGPGAGPNQMNPGVAMGPGGVVGPAGGGGVMGPGPNQMLGAGGAGGPGAGQQGNFVGMGANAMVRKPPEMMPGGNVYPGSGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPPSHPGQMIPSPALIPSPNPHMGGVAQRSTIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREK
2) PPAKQSRLALDDTGAAGGTGGGVTTGGATTTTTSTTTAAATTGSASSTTSTAASSTTAPQE
3) SNFRQSVVNKINEAIQQTGMTSSKNGIEMENHVF
4) SNLLHSLRPQMQMGGMGGPMQGNRVGMGPGNQMGGMMGGPNQMQGPGAGMVGGMPGQMGVGMGPGGMSGGKIVGMGGQQQQ
152
705
10
70
596
765
43
150










Molecular Recognition Features






MoRF SequenceStartStop




NANANA