<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08202

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSASGTAAVSGGSLPALLMANGGGGSGGPGGGPGGGKGIGKPDIKPPGGGGPSTGGTGTAGKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFQEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPAGGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHTLYTLSLQHYADVHAQLHKAPLGVVQKRRGGHPMRLTYFVAPYELLDLTTRTMNVLSAELIAQERIGCSVAVVLEASSANKLQIQPLLVVNAGSGSAASVLQPVYTPIEKHNSTSLPATFVLRLSKPMPLNSAMMRAIRGIVGGSGAGEQQQAGEGSSGGGGGGGLPGSLLGLIAHHASAGSVTDLAKGLLVSLPDQYHCYFLTDNPSLRGMMVSSIPFTEPQHVPKILTYLRQQAVFNQLLSSCIRTNAPGGGGGRPSALQQLLDGGSVHTIENGTTGGLLVFEVSALSCQNITVSLIHPYEESLATVEFDLQNIANIAVRIYCSEGETSDEHTVERISAVLQRCMSIPVTLRALMKAWEEEHEQKFKPNVLGSSTVSSGGAGGGPGGGGGGGGAGGAAPGLNNGGDGTGPAGGGLTGTGDDGTMNGFNLSSLGGPGPAVDGSGAGGGGGSAATNGTAAAQQQRGLMNGEGNGLTVSGGGSLGLDFCDMLTERNGSGLGAAAAIGIVGGRAPGGMGAREPPEPLAGGAAKKRRMEDFCKSPKSDSNLSVGGGGGGGASDAVGTEKANTGAAGVAGATGATSSSSTTTTTITSQDVGAAASGATGAGNSSEQRLQTGGATEEDTGGLPLFGETVPAAAGTDAKGSSLGGTTTTNAMISAKNEPPSVLPTGGGDGDTATGATMPLQSSSSSSLSSLSSAGFSLAGGPLAGEPAPDRPCPGTLLLESLDFSALEPDAAKRSTGGGQPTKRRRSSSSSSSSSSSSSSSSSSSSSTSAASDELEESVDLVEAEMSSFFAETNNTQPVAAIAKASFGSPSGKPALGAVSPIASKVVSPSGGAGLEKTPLPTISGSGLEIIPLATSAGTVAASGFPSPSVTSAPIAVPQSNATGSTSSTTATSSSTAKKSSSSSGGGSGSHRKTSDSSERTSSSKSEKKKKRKTDDSAMGPPNKLPYKSSGESSPHRSGGGVGGSSLSTSKSSPKHSSPVHHSSPKHSGSGGPLGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGSKSSDVGGGGGGGGGTSGASISTAGSSSKERDKERSEKKALQFGTANTATGSSSLTATSAAGSSSSSSSGGRSKNSSLKLKQLDLAAGSSMSISMAAGIGDAGSSSPVAPMIDLTGPVPGAAAALGGLGLPGPGMTTASSMLQALQAAKNRKTPTAAGGSTGLGGSLSAVIDKLKSAQSADDEAVLILPEMTITQQTTSASLAAGTGGIGTGVNIGGFGGLKDSAKSGSGLLPSGGTSSLANCVSSTAGIAGAALTQSSSVTSAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSNKSSSSSSNSGSGSKSSNKSGLKSGVSSGPVSSKQQQQQQQQQQSNHTTSFSGAFPSSTKSPHYTSSTSGSSKAPFQKSNSFGSLGGSGGTGMKASKVSSPKSTSNPASSSSSSAYSSKEKGGSTSGRSKSSSASSLTGAMLTGATGGTGSGTGSSSSALVNPISIMKMLGYPTGSMGNMEGFAKTLDTKFQIPKLSARSNSSATGTTSTGASESGEAGSKSAKDPAARKQKQQTPVTTAAPSVGSSPVRQFSSTSPSGEASARLLSDLLGAAAKSSNKMAPGTGATAVDGTAGTGGGVGGAGLHPLLPNIVQKMFGSDGSLQTKSNSSDGSMFPTAGRASPGMLSGSASRDGFRSGGGSGSAPGTPTTTSSMVLPPFPSPISGGASNDGDLGSGTLMRPPSRPSSTISNHSHSSQDGIGGGSGNSGDAVAGSTPAVASMASMMMMNAMSAAAGGGQSPASTGGSLPLDSTSTQQLIAALAAKSGVLPPPPPNNLLNNHHSNHLNNHVVGGAAALNNLPSPASVSVHLVKSPAPSPLPFASPHSNASSTHAAGAAGLDDDLMDEALIGIGSK
Length2160
PositionMiddle
OrganismAnopheles quadriannulatus (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.272
Instability index53.37
Isoelectric point9.08
Molecular weight212027.36
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08202
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|    1350.33|     159|     160|     863|    1021|       1
---------------------------------------------------------------------------
  616-  686 (76.95/ 8.58)	......................................................................................................................KP...................NVLG..SST..........VSSGGAGG..G..PGGGG...G......GGGA..GGAAP........GLNNGGD.............GT..GPAG............GGLTG.TGD....DGTMNG.FNLSSL.....................G.GP......GP
  687-  833 (129.31/21.49)	........AVDGSGAGGGGGSAATNGTAA.......aqqqrglmNGegnG......L...T.............VSGGGSL.....G.....LdFCD...MLT.E..RNGSG.lG...AA...................AAIGivGGRAPGGM......GAR.EPP..E..PLAGG............AA..KKRRM........EDFCKSPKSDSNL...S.VGG......G............G...GGGAS....D..AVGT...EKANTGAAG.......VAGATGATS.SS......ST
  834-  992 (242.80/49.47)	TTTTITSQDVGAAASGATGAGNSSEQRLQ...............TG...G......A...T.............EEDTGGL.....P.....L.FGE...TVP.A..AAGTD..A...KG...................SSLG..GTTTTNAM.....ISAKNEPP..SVLPTGGG...D......GDTA..TGATM........PLQSSSSSSLSSL...S.SAGF..SLAG............GPLAGEPAP....DRPCPGTLLLESLDFSALE.......PDAAKRSTG.GG......QP
  993- 1145 (139.39/23.97)	TKRRRSSSSSSSSSSSSSSSSSSSSSTSA...............AS...D......E...L.............EESVDLVeaemsS.....F.FAEtnnTQP.V..AAIAK..A.........................SFG..SPSGKPALgavspIASKVVSP..S.....GG...A......GLEK..T............PLPTISGSGLEIIplaT.SAGT..VAAS............G....FPSP....SVTSAPIAVPQS......N.......ATGSTSSTT.AT......SS
 1146- 1301 (167.34/30.87)	STAKKSSSSSGGGSGSHRKTSDSSERTSS...............SK...SekkkkrK...T.............DDSAMGP.....P.........N...KLPyK..SSGES..SphrSG...................GGVG..GSSLSTSK.....SSPKHSSPvhHSSPKHSG...S......GG.P..LGFHS........PKHGSSVSPKHPL...H.SGGS..STGG............GK...............PSMSALKSAAASGSS.......PGSKSSDVG.GG......GG
 1302- 1455 (129.81/21.61)	GGGGTSGASISTAGSSSKERDKERSEKKA..............lQF...G......T...A.............NTATGSS.....S.....L.......TAT.S..AAGSS..S...SS...................SS.G..G................RSKN..SSLKL..K...Q......LDLA..AG..................SSMSIS...M.AAGI..GDAGssspvapmidltGPVPGAAAAlgglGLPGPGMTTASSM.LQALQaaknrktPTAAGGSTGlGG........
 1456- 1580 (89.08/11.57)	...........SLSAVIDKLKSAQS...............................A...D.............DEAVLIL.....P..emtI.TQQ...TTS.AslAAGTGgiG...TG...................VNIG..GFGGLKD.......SAKS.GS..GLLPSGGT...SslancvSSTAgiAGAAL........T.QSSSVTSAPSL...T.AA.....LTS............GK.ASE.......Y......MV.........K.......P.....SSD.GI......KL
 1581- 1711 (121.74/19.62)	TIQNKKGSNKSSSSSSNSGSGSKSSNKSG.............lkSG...V......S...SgpvsskqqqqqqqQQQSNHT.....T.....S.FSG...AFP.S..STKSP..H...YT...................SSTS..G..SSKAP.....FQKSNSFG..S.LGGSGG...T......GMKA..SKVSS........P..KSTSNPASSS...S.SSAY..S............................................SKE.......K.........GG........
 1712- 1894 (111.15/17.01)	.......STSGRSKSSSASSLTGAMLTGA...............TG...G......TgsgT.............GSSSSAL...vnPisimkM.LG.....YP.T..GSMGN..M...EGfaktldtkfqipklsarsnSSAT..GTTSTGAS.....ESGEAGSK..SAKDPAAR...K......QKQQ..TPVTTaapsvgssPVRQFSSTSPSGE...A.SARLlsDLLG...............AAAKSS....NKMAPGT......GATAVD.......GTA...GTG.GGvggaglHP
 1900- 2045 (142.76/24.80)	VQKMFGSDGSLQTKSNSSDGSMFPTAGRAspgmlsgsasrdgfrSG...G......G...S..........................................................G...................SAPG..TPTTTSSM.....V....LPP..FPSPISGGasnD......GDLG..SGTLM........RPPSRPSSTISNH...ShSSQD..GIGG............G..SGN.SG....DAVAGSTPAVASMA.SMMM.......MNAMSAAAG.GG......Q.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.32|      16|      20|    2095|    2113|       3
---------------------------------------------------------------------------
 2095- 2111 (24.49/10.11)	HVVGGAAAlNNLP..SPAS
 2115- 2132 (24.83/ 8.83)	HLVKSPAP.SPLPfaSPHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.04|      17|      20|     424|     442|       4
---------------------------------------------------------------------------
  424-  442 (23.90/21.30)	HASAgsVTDLA..KGLLVS.LP
  446-  465 (26.14/15.28)	HCYF..LTDNPslRGMMVSsIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.13|      13|      18|     383|     395|       5
---------------------------------------------------------------------------
  383-  395 (23.82/ 8.01)	RAIRGIVGGSGAG
  399-  411 (25.31/ 9.14)	QAGEGSSGGGGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.30|      19|      20|     120|     139|       7
---------------------------------------------------------------------------
  120-  139 (29.84/23.30)	LQKTLD..SMqYCIKVTTRQGL
  489-  501 (18.24/ 7.27)	....LS..S...CIRTNAPGGG
  508-  528 (28.23/16.26)	LQQLLDggSV.HTIENGTTGGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08202 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGRAPGGMGAREPPEPLAGGAAKKRRMEDFCKSPKSDSNLSVGGGGGGGASDAVGTEKANTGAAGVAGATGATSSSSTTTTTITSQDVGAAASGATGAGNSSEQRLQTGGATEEDTGGLPLFGETVPAAAGTDAKGSSLGGTTTTNAMISAKNEPPSVLPTGGGDGDTATGATMPLQSSSSSSLSSLSSAGFSLAGGPLAGEPAPDRPCPGTLLLESLDFSALEPDAAKRSTGGGQPTKRRRSSSSSSSSSSSSSSSSSSSSSTSAASDELEES
2) GKPALGAVSPIASKVVSPSGGAGLEKTPLPTISGSGLEIIPL
3) GSLPALLMANGGGGSGGPGGGPGGGKGIGKPDIKPPGGGGPSTGGTGTAGKVLL
4) GSMGNMEGFAKTLDTKFQIPKLSARSNSSATGTTSTGASESGEAGSKSAKDPAARKQKQQTPVTTAAPSVGSSPVRQFSSTSPSGEASARLLSDLLGAAAKSSNKMAPGTGATAVDGTAGTGGGVGGAGLHPLLPNIVQKMFGSDGSLQTKSNSSDGSMFPTAGRASPGMLSGSASRDGFRSGGGSGSAPGTPTTTSSMVLPPFPSPISGGASNDGDLGSGTLMRPPSRPSSTISNHSHSSQDGIGGGSGNSGDAVAGSTPAVASMASMMMMNAMSAAAGGGQSPASTGGSLPLDSTSTQQ
5) HEQKFKPNVLGSSTVSSGGAGGGPGGGGGGGGAGGAAPGLNNGGDGTGPAGGGLTGTGDDGTMNGFNLSSLGGPGPAVDGSGAGGGGGSAATNGTAAAQQQRGLMNGEGNGLT
6) IAALAAKSGVLPPPPPNNLLNNHHSNHLNNHVVGGAAALN
7) KPSSDGIKLTIQNKKGSNKSSSSSSNSGSGSKSSNKSGLKSGVSSGPVSSKQQQQQQQQQQSNHTTSFSGAFPSSTKSPHYTSSTSGSSKAPFQKSNSFGSLGGSGGTGMKASKVSSPKSTSNPASSSSSSAYSSKEKGGSTSGRSKSSSASSLTGAMLTGATGGTGSGTGSSSSAL
8) SVSVHLVKSPAPSPLPFASPHSNASSTHAAGAAGL
9) TSAGTVAASGFPSPSVTSAPIAVPQSNATGSTSSTTATSSSTAKKSSSSSGGGSGSHRKTSDSSERTSSSKSEKKKKRKTDDSAMGPPNKLPYKSSGESSPHRSGGGVGGSSLSTSKSSPKHSSPVHHSSPKHSGSGGPLGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGSKSSDVGGGGGGGGGTSGASISTAGSSSKERDKERSEKKALQFGTANTATGSSSLTATSAAGSSSSSSSGGRSKNSSLKLK
756
1063
12
1763
611
2065
1572
2111
1106
1029
1104
65
2063
723
2104
1748
2145
1371










Molecular Recognition Features






MoRF SequenceStartStop




1) AAKKRRMEDF
2) GGKGIGKPDIKPP
3) KKALQF
4) LKLKQLDLA
5) LSDLL
6) SALKSAAA
776
35
1328
1368
1854
1277
785
47
1333
1376
1858
1284