<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08202

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSASGTAAVSGGSLPALLMANGGGGSGGPGGGPGGGKGIGKPDIKPPGGGGPSTGGTGTAGKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFQEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPAGGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHTLYTLSLQHYADVHAQLHKAPLGVVQKRRGGHPMRLTYFVAPYELLDLTTRTMNVLSAELIAQERIGCSVAVVLEASSANKLQIQPLLVVNAGSGSAASVLQPVYTPIEKHNSTSLPATFVLRLSKPMPLNSAMMRAIRGIVGGSGAGEQQQAGEGSSGGGGGGGLPGSLLGLIAHHASAGSVTDLAKGLLVSLPDQYHCYFLTDNPSLRGMMVSSIPFTEPQHVPKILTYLRQQAVFNQLLSSCIRTNAPGGGGGRPSALQQLLDGGSVHTIENGTTGGLLVFEVSALSCQNITVSLIHPYEESLATVEFDLQNIANIAVRIYCSEGETSDEHTVERISAVLQRCMSIPVTLRALMKAWEEEHEQKFKPNVLGSSTVSSGGAGGGPGGGGGGGGAGGAAPGLNNGGDGTGPAGGGLTGTGDDGTMNGFNLSSLGGPGPAVDGSGAGGGGGSAATNGTAAAQQQRGLMNGEGNGLTVSGGGSLGLDFCDMLTERNGSGLGAAAAIGIVGGRAPGGMGAREPPEPLAGGAAKKRRMEDFCKSPKSDSNLSVGGGGGGGASDAVGTEKANTGAAGVAGATGATSSSSTTTTTITSQDVGAAASGATGAGNSSEQRLQTGGATEEDTGGLPLFGETVPAAAGTDAKGSSLGGTTTTNAMISAKNEPPSVLPTGGGDGDTATGATMPLQSSSSSSLSSLSSAGFSLAGGPLAGEPAPDRPCPGTLLLESLDFSALEPDAAKRSTGGGQPTKRRRSSSSSSSSSSSSSSSSSSSSSTSAASDELEESVDLVEAEMSSFFAETNNTQPVAAIAKASFGSPSGKPALGAVSPIASKVVSPSGGAGLEKTPLPTISGSGLEIIPLATSAGTVAASGFPSPSVTSAPIAVPQSNATGSTSSTTATSSSTAKKSSSSSGGGSGSHRKTSDSSERTSSSKSEKKKKRKTDDSAMGPPNKLPYKSSGESSPHRSGGGVGGSSLSTSKSSPKHSSPVHHSSPKHSGSGGPLGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGSKSSDVGGGGGGGGGTSGASISTAGSSSKERDKERSEKKALQFGTANTATGSSSLTATSAAGSSSSSSSGGRSKNSSLKLKQLDLAAGSSMSISMAAGIGDAGSSSPVAPMIDLTGPVPGAAAALGGLGLPGPGMTTASSMLQALQAAKNRKTPTAAGGSTGLGGSLSAVIDKLKSAQSADDEAVLILPEMTITQQTTSASLAAGTGGIGTGVNIGGFGGLKDSAKSGSGLLPSGGTSSLANCVSSTAGIAGAALTQSSSVTSAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSNKSSSSSSNSGSGSKSSNKSGLKSGVSSGPVSSKQQQQQQQQQQSNHTTSFSGAFPSSTKSPHYTSSTSGSSKAPFQKSNSFGSLGGSGGTGMKASKVSSPKSTSNPASSSSSSAYSSKEKGGSTSGRSKSSSASSLTGAMLTGATGGTGSGTGSSSSALVNPISIMKMLGYPTGSMGNMEGFAKTLDTKFQIPKLSARSNSSATGTTSTGASESGEAGSKSAKDPAARKQKQQTPVTTAAPSVGSSPVRQFSSTSPSGEASARLLSDLLGAAAKSSNKMAPGTGATAVDGTAGTGGGVGGAGLHPLLPNIVQKMFGSDGSLQTKSNSSDGSMFPTAGRASPGMLSGSASRDGFRSGGGSGSAPGTPTTTSSMVLPPFPSPISGGASNDGDLGSGTLMRPPSRPSSTISNHSHSSQDGIGGGSGNSGDAVAGSTPAVASMASMMMMNAMSAAAGGGQSPASTGGSLPLDSTSTQQLIAALAAKSGVLPPPPPNNLLNNHHSNHLNNHVVGGAAALNNLPSPASVSVHLVKSPAPSPLPFASPHSNASSTHAAGAAGLDDDLMDEALIGIGSK
Length2160
PositionMiddle
OrganismAnopheles quadriannulatus (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.272
Instability index53.37
Isoelectric point9.08
Molecular weight212027.36
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08202
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|    1350.33|     159|     160|     863|    1021|       1
---------------------------------------------------------------------------
  616-  686 (76.95/ 8.58)	......................................................................................................................KP...................NVLG..SST..........VSSGGAGG..G..PGGGG...G......GGGA..GGAAP........GLNNGGD.............GT..GPAG............GGLTG.TGD....DGTMNG.FNLSSL.....................G.GP......GP
  687-  833 (129.31/21.49)	........AVDGSGAGGGGGSAATNGTAA.......aqqqrglmNGegnG......L...T.............VSGGGSL.....G.....LdFCD...MLT.E..RNGSG.lG...AA...................AAIGivGGRAPGGM......GAR.EPP..E..PLAGG............AA..KKRRM........EDFCKSPKSDSNL...S.VGG......G............G...GGGAS....D..AVGT...EKANTGAAG.......VAGATGATS.SS......ST
  834-  992 (242.80/49.47)	TTTTITSQDVGAAASGATGAGNSSEQRLQ...............TG...G......A...T.............EEDTGGL.....P.....L.FGE...TVP.A..AAGTD..A...KG...................SSLG..GTTTTNAM.....ISAKNEPP..SVLPTGGG...D......GDTA..TGATM........PLQSSSSSSLSSL...S.SAGF..SLAG............GPLAGEPAP....DRPCPGTLLLESLDFSALE.......PDAAKRSTG.GG......QP
  993- 1145 (139.39/23.97)	TKRRRSSSSSSSSSSSSSSSSSSSSSTSA...............AS...D......E...L.............EESVDLVeaemsS.....F.FAEtnnTQP.V..AAIAK..A.........................SFG..SPSGKPALgavspIASKVVSP..S.....GG...A......GLEK..T............PLPTISGSGLEIIplaT.SAGT..VAAS............G....FPSP....SVTSAPIAVPQS......N.......ATGSTSSTT.AT......SS
 1146- 1301 (167.34/30.87)	STAKKSSSSSGGGSGSHRKTSDSSERTSS...............SK...SekkkkrK...T.............DDSAMGP.....P.........N...KLPyK..SSGES..SphrSG...................GGVG..GSSLSTSK.....SSPKHSSPvhHSSPKHSG...S......GG.P..LGFHS........PKHGSSVSPKHPL...H.SGGS..STGG............GK...............PSMSALKSAAASGSS.......PGSKSSDVG.GG......GG
 1302- 1455 (129.81/21.61)	GGGGTSGASISTAGSSSKERDKERSEKKA..............lQF...G......T...A.............NTATGSS.....S.....L.......TAT.S..AAGSS..S...SS...................SS.G..G................RSKN..SSLKL..K...Q......LDLA..AG..................SSMSIS...M.AAGI..GDAGssspvapmidltGPVPGAAAAlgglGLPGPGMTTASSM.LQALQaaknrktPTAAGGSTGlGG........
 1456- 1580 (89.08/11.57)	...........SLSAVIDKLKSAQS...............................A...D.............DEAVLIL.....P..emtI.TQQ...TTS.AslAAGTGgiG...TG...................VNIG..GFGGLKD.......SAKS.GS..GLLPSGGT...SslancvSSTAgiAGAAL........T.QSSSVTSAPSL...T.AA.....LTS............GK.ASE.......Y......MV.........K.......P.....SSD.GI......KL
 1581- 1711 (121.74/19.62)	TIQNKKGSNKSSSSSSNSGSGSKSSNKSG.............lkSG...V......S...SgpvsskqqqqqqqQQQSNHT.....T.....S.FSG...AFP.S..STKSP..H...YT...................SSTS..G..SSKAP.....FQKSNSFG..S.LGGSGG...T......GMKA..SKVSS........P..KSTSNPASSS...S.SSAY..S............................................SKE.......K.........GG........
 1712- 1894 (111.15/17.01)	.......STSGRSKSSSASSLTGAMLTGA...............TG...G......TgsgT.............GSSSSAL...vnPisimkM.LG.....YP.T..GSMGN..M...EGfaktldtkfqipklsarsnSSAT..GTTSTGAS.....ESGEAGSK..SAKDPAAR...K......QKQQ..TPVTTaapsvgssPVRQFSSTSPSGE...A.SARLlsDLLG...............AAAKSS....NKMAPGT......GATAVD.......GTA...GTG.GGvggaglHP
 1900- 2045 (142.76/24.80)	VQKMFGSDGSLQTKSNSSDGSMFPTAGRAspgmlsgsasrdgfrSG...G......G...S..........................................................G...................SAPG..TPTTTSSM.....V....LPP..FPSPISGGasnD......GDLG..SGTLM........RPPSRPSSTISNH...ShSSQD..GIGG............G..SGN.SG....DAVAGSTPAVASMA.SMMM.......MNAMSAAAG.GG......Q.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.32|      16|      20|    2095|    2113|       3
---------------------------------------------------------------------------
 2095- 2111 (24.49/10.11)	HVVGGAAAlNNLP..SPAS
 2115- 2132 (24.83/ 8.83)	HLVKSPAP.SPLPfaSPHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.04|      17|      20|     424|     442|       4
---------------------------------------------------------------------------
  424-  442 (23.90/21.30)	HASAgsVTDLA..KGLLVS.LP
  446-  465 (26.14/15.28)	HCYF..LTDNPslRGMMVSsIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.13|      13|      18|     383|     395|       5
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  383-  395 (23.82/ 8.01)	RAIRGIVGGSGAG
  399-  411 (25.31/ 9.14)	QAGEGSSGGGGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.30|      19|      20|     120|     139|       7
---------------------------------------------------------------------------
  120-  139 (29.84/23.30)	LQKTLD..SMqYCIKVTTRQGL
  489-  501 (18.24/ 7.27)	....LS..S...CIRTNAPGGG
  508-  528 (28.23/16.26)	LQQLLDggSV.HTIENGTTGGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08202 with Med1 domain of Kingdom Metazoa
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