<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08196

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMIMDNSKTTSKTTLLKLMLLRAWKERWTDCQWGINVKTILTRGVSGDVYNLADAIVQQAVVGSGANMLFLSYLKHSLCAHLISHAAVLNRIAKYDQFDKHHCLIALLDFLKSIIDGVTCRGKQEESILTKATVALVHWLLQIYECILKSYAESRALQTEEEDVVQRVATVLERIVENPFLLGVISIGKCEDPEQFITLQKRFNGINNLTLTTGYVAHVGSNQKNVTVTDYMRKLVLLEVDILEMKLFDGGKVEPITFSLQPFMAIEVLLNPMCETNQYVAQLINLKRLKGYSYARLYCEIMRGCLISLNNVEGTSKESLMCAFAFIKVPHIIHQIHTKTSGKEQQDEATSTNYSVEVLEAFELLLQDDPVLDYMDMKCSCNIVECLLKEMVKHNLLTETHVKHFVALREPVTLGLHKLEANNAQLTLMLKFVFRVESPLVGILKALSTDHSKVQDALLAMLCQVLTGNSLDLVLSVASVEGKFKAFISGLLKCNDYAKQATSVEIGKASTTRGALFDVTFMILASIAQSYGSDVILAEGGNSFFEKWVRDYMVERKKSKSPMTMVKQADPMVLEELIMALNNTEGGGLKASNLRWEDICYTIPALLHQVLMAWENETLSPVEIKKMLDGLKAHFCSFAVCASSWLCAYMQMVRQDEQVKPMNMVQQLCSALTGPQAEEWQQQDYCKERFGLMGQIIRRMQQEFQRTPQINPKLRALFPSQHMVSHLPLEEQFEEAWKAIAERGWLPIETTFLLDTLLQSCGPSWLVEKLIAKLFLCKYIRDLNKTMDIIFAIMHLDIERCTIALLSQLVPMMLLNKQQTPEIVDPQSRVLAKLCVYCIIVTMETSLTASKKRTRGTVGTDMEDIDSLCTSAKLRKIDLDGMSVGCEATGGNDFALESALDSTACWDATSVPSLKEPLQGCLQTLFRTFTQYITTDELSPKVYFVFQFLSLLVESGRERIMCVLKLIPNGLVQNLLKINATDEMTVGLILRLYDLNTPSGRQFAMSDICLLRNIQMRKESIKL
Length1022
PositionTail
OrganismAnopheles minimus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.07
Grand average of hydropathy0.069
Instability index39.49
Isoelectric point6.19
Molecular weight115232.59
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08196
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.35|      13|      32|     570|     582|       1
---------------------------------------------------------------------------
  570-  582 (22.70/12.94)	PMVLEELIMALNN
  603-  615 (24.65/14.63)	PALLHQVLMAWEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.97|      19|      32|     816|     834|       2
---------------------------------------------------------------------------
  816-  834 (32.35/21.38)	KQQTPEIVDPQSRVLAKLC
  850-  868 (32.62/21.63)	KKRTRGTVGTDMEDIDSLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.80|      28|      41|     941|     968|       3
---------------------------------------------------------------------------
  941-  968 (48.18/31.90)	VYFVFQFLSLLVESGRERIMCVLKLIPN
  985- 1012 (48.62/32.25)	VGLILRLYDLNTPSGRQFAMSDICLLRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     226.95|      72|     695|      22|     110|       5
---------------------------------------------------------------------------
   22-  110 (110.19/116.29)	AWKerwtdcqwginvkTILTRG.VSGDVYNLADAIVQqavvGSGANMLFLSYL.KHSLCAHLISHAAVLNRIAKYDQFDKHHCLIALLDFL
  735-  808 (116.75/82.63)	AWK.............AIAERGwLPIETTFLLDTLLQ....SCGPSWLVEKLIaKLFLCKYIRDLNKTMDIIFAIMHLDIERCTIALLSQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.83|      19|      30|     219|     237|       6
---------------------------------------------------------------------------
  219-  237 (31.75/21.67)	GSNQKNVTVT..DYMRKLVLL
  249-  269 (28.08/18.33)	GGKVEPITFSlqPFMAIEVLL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08196 with Med24 domain of Kingdom Metazoa
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