<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08194
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MAPQPLEQGGAVTSFIPTGQEMTQRQNLIPLGRLIDFIIQRTYHELTVLAELLPRKTDMDRKIEIYNFSASTRQLFIRLLALVKWANSASKVDKSAKIMGFLDKQSMLFIDTADMLSRVARETLVHARLPNFHIPAAVEILTTGSYSRLPSVIRDRIVPPDPITPAEKRQTLQRLNQVIQHRLVTGSLLPQLRKFRIENGRVTFKVDHEFEVSLTVMGDAPTVPWRLLDIDFLVEDKETGDGKALVHPLQVNYIHQLIQGRIVDCTDALAEVYTCLHYFCQSLQLEVLYTQTLRLIRDRLDDHIHVDEYVVGSRLTVSYWRELTNKDPKSELGYRLTIQTDPNDAAKQLAILHVPSIGNKEADIADRAVRSDLLSMERLLVHTVYVRSLARLNDVKAELQLFLKDVEYHIQGTPAMLTVPVLNPCLRAEHIYITVDTHTGMLRCHVPKHLDCPIMPEMQHALNNDWSKLQHLISELRYWITQRRCEKTLQHLPAATQDRLPLIFPQNHPINRMGPHKVFIQLYRHANVILIVELKEKKTCPNEMTYTFYLVLVKPSSVEEGQSQDAAAAGQANTSSGAGGHASGNEQTTASMPKMYLRVLSMIEFDTFVATHGPGTYIDDPSPTCSSSKRKISPLDSAMSSMGPPLKQQKTIYPAYFIPELAHVVAMCDEKLPFVTLAKEFTMRKIPHGGLQVEANATSLVLKLLTLPQPKPPQVPPSAQQQQQQQQQQQQSGQSGSDAKAAAAASANEPKTVHVPPIDKQVWIALLKRLLSVSVRAQVNKSNQTRLWTVELVFYGSPLPSLHHKEQGMRRAVYLQYEMQPVESVSKVVDQLLSDWSKIVYLYTLVHEFREQFNNEKYNLQSMVTIKSYSYTNLLLAYGPNKDVSVNICWDTEAKEFRLVFTGGNSAINAHSMMRDQLQAHLNHNYSLAQIVHMLHETYQPLSSIAKLPIIPHLAILQSPKIPVLSFCIIPQSPTLLRISFQGVYCLEVRFRGGGLCTIRDGAYSRFDRSHVVEEFTPTQGLKGFLSKYVDETAVFRRRSQSEDDNPPSPVTLEDPSGHVGAGGGSGGGNNGGTGGGGGTGGGSNTFLSGGTGMRGPQSPRDPGLRFAAPLTPPTSSNPHTPASPHPIGGGGGAGGAGGGGAGGSGGQGGQQQGHMNNFNMTSPPASHMPHPSPSGGLMPSSPLNAQPSPMAAHSPGPSSLPYMQSHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTSHHYASRVLPARSWAGAIPTTLTYEALDTLCRATSHPQKEVPGPELSPLERFLGSVFMRRQLQRIIHQEESLMAITSNEPGVVVFKADCLQYQVFLNPNHMQSLHLKVDQLPMGPMMDGKPPYQWAAQDLQILEQFFDQRVAAPPYRPAVMTSFTRMLNLPAKVLKDFIQIMRLDLMPELVQGNKWNVQFVLRVPPSATPIVPVGTTTILSHRQKILFFIQITRVPYMPNMEWKDAVTMLLPMVYDMNMNHTTLAERREPMPPQLNSAVSAHLRRFSECSVLLPDECSLFPAVHDLLLTLTLPNEPPAPGQMQMQMGGVMQPGGGPGGPGGPGGPMGGQIGGPSPQVVPQVGSSPSPMMHSPMQQMGGGGQQPGAYGGMVGGPGGGPQSGGPGGPGGGGV |
Length | 1646 |
Position | Tail |
Organism | Anopheles minimus |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae>
Anophelinae> Anopheles.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.281 |
Instability index | 54.06 |
Isoelectric point | 8.54 |
Molecular weight | 180663.22 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP08194
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
5| 388.55| 57| 60| 1038| 1094| 1
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1038- 1094 (107.87/34.13) RRSQSEDD......NP.....PSPVTLEDP....SGH.VGAGGGSGGGNNGGTGG....G..GGTGGGS....NTFLS.......GGTGM
1095- 1161 (73.45/21.21) RGPQSPRDpglrfaAP.....LTPPTSSNPhtpaSPHpIGGGGGAGGAGGGGAGG....S..GGQGGQQqghmNNF............NM
1162- 1229 (72.70/20.92) .TSPPASH......MP....hPSPSGGLMP....SSP.LNAQPSPMAAHSPGPSSlpymQ..SHTDGSP....FAALSpaasnwpGSPGM
1552- 1588 (61.58/16.75) ...............P.....PAPGQMQMQ....MGG.VMQPGG....GPGGPGG....P..GGPMGGQ.......IG.......G....
1589- 1639 (72.94/21.02) ...PSPQV......VPqvgssPSP....MM....HSP.MQQMGG..GGQQPGAYG....GmvGGPGGGP....Q...S.......GGPG.
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 76.71| 27| 63| 1341| 1374| 4
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1341- 1374 (37.94/37.08) FLN.P.....NHMQSLHLkvDQLPmgPMMDGKppyQWAAQ
1403- 1435 (38.77/17.88) MLNlPakvlkDFIQIMRL..DLMP..ELVQGN...KWNVQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 51.53| 13| 41| 709| 721| 8
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709- 721 (26.44/14.00) QPKPPQVPPSAQQ
749- 761 (25.09/12.82) EPKTVHVPPIDKQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 170.40| 52| 329| 163| 216| 9
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163- 216 (81.89/55.11) ITPAEKRQTLQRLNQVIQHRLVTgsLLPQLRKF.RIENGRVTFKVDHEFEVSLTV
480- 532 (88.51/53.70) ITQRRCEKTLQHLPAATQDRLPL..IFPQNHPInRMGPHKVFIQLYRHANVILIV
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