<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08191

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIDMESHVFHKARNKDEYLGFVARLILHVREMNTKHKNQQNAAAAAAQQAQQDGSGSSGQQSGGGGGGGSGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMGGQMGGTGNASNLLHSLRPQMQMGGMGGPMQANRVGMGPGPSNQMGGMMGPNQMQGPGAGMVGGMPGQMGVGIGPGGMSGGKIVGMGGQQQQMAQLNAMQVNQMQQAQQQQQQGGMPQPQQQQQGGLVQGQGGPVQQMGVGPGGPNQMNPMVMGQIQAQLQNQSAMGGQQMGTVGGAMNAANQMGPMVGANAGMNSQAMGMAPNQVLRQQQQQQGMGQVQMGLGPGQMGQLNAGVQVGQQGNFVGMVRKPPDMMPGGNVYPGSGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPPSHPGQMIPSPALIPSPNPHMSGVAQRSNIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKYRALTKYIEPLKRMIAKMENDDIDKIAKMKRLLEILSNPSVRIPLETLHKCEAALTSQLGSIRETPTNNPLVEAVSSSLQGASGNHTLQRTFRPCLEALFGPDIKNLPPPSKQPRLAQDDSITVNGGTAGGGVTSGGATTTTSTTTAVTSTASGGNTAGSAATTNTTTSTAPQEIPHILQVEIARLDQKFKVSLDQCAISGTRTIKLICWLDDKNLPCVPPVAVTIPEDYPLTAPSCSLIEQEYNATPFLILVQKSLMARICKLPGLFTLSHLLDTWEMSVRQACSPNPTIVAPTGTSVLLGM
Length798
PositionTail
OrganismAnopheles minimus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.416
Instability index49.98
Isoelectric point9.18
Molecular weight82864.40
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08191
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     485.01|      80|      88|     102|     188|       1
---------------------------------------------------------------------------
  108-  188 (149.74/44.50)	DPINALQnlaSQGTRPQMMG..QMG..V..GPGGP..MGG.QMGGTG.........NA..SNLLHSLRPQMQMGGMGGPMQANRVGM..GP.GPS....NQM.GGMMGP......
  200-  282 (88.03/22.72)	............GGMP...G..QMG..VgiGPGGM..SGG.KIVGMGgqqqqmaqlNAmqVNQMQQAQQQQQQGGMPQPQQQQQGGLvqGQgGPV....QQM.G..VGPgG...P
  283-  343 (75.73/16.03)	...NQMN........PMVMG..QIQaqL..QNQSA..MGGqQMGTVG.........GA..MNAANQMGP...MVGANAGMNSQAMGM..AP........NQV.............
  345-  403 (76.56/20.55)	..........RQQQQQQGMGqvQMG..L..GP.GQ..MG..Q........................LNAGVQVG.....QQGNFVGM..VR.KPP....DMMpGGNVYP.GsggA
  408-  478 (94.96/22.54)	TPNNFLR....QSPSPSVPS..PVG..P..GAHGPpsHPG.QMIP............S..PALIPSPNPH.....MSGVAQRSNIGQ..SP.GGSlntpGQP.GG..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.73|      20|      22|     623|     642|       2
---------------------------------------------------------------------------
  623-  642 (37.48/19.26)	TAGGGVTSGGATTT.TSTTTA
  646-  666 (32.25/15.56)	TASGGNTAGSAATTnTTTSTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.11|      16|      17|     503|     518|       3
---------------------------------------------------------------------------
  503-  518 (26.96/19.78)	IEPLKRMIAKMENDDI
  521-  536 (25.15/17.96)	IAKMKRLLEILSNPSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08191 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALTSQLGSIRETPTNNPLVEAVSSSLQGASGNHT
2) AQLNAMQVNQMQQAQQQQQQGGMPQPQQQQQGGLVQGQGGPVQQMGVGPGGPNQMNPMVMGQIQAQLQNQSAMGGQQMGTVGGAMNAANQMGPMVGANAGMNSQAMGMAPNQVLRQQQQQQGMGQVQMGLGPGQMGQLNAGVQVGQQGNFVGMVRKPPDMMPGGNVYPGSGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPPSHPGQMIPSPALIPSPNPHMSGVAQRSNIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKY
3) DIKNLPPPSKQPRLAQDDSITVNGGTAGGGVTSGGATTTTSTTTAVTSTASGGNTAGSAATTNTTTSTAPQE
4) MAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIDMESHVFH
5) VREMNTKHKNQQNAAAAAAQQAQQDGSGSSGQQSGGGGGGGSGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMGGQMGGTGNASNLLHSLRPQMQMGGMGGPMQANRVGMGPGPSNQMGGMMGPNQMQGPGAGMVGGMPGQMGVGIGPGGMSGGKIVGMGGQQQQ
549
231
598
1
63
582
496
669
44
229










Molecular Recognition Features






MoRF SequenceStartStop




NANANA