<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08186

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSAELRIVKLFEEVLVGMAMIAGFSFALLWLMLRNPVLTSICTFQEDKNIVPSFDEEEQRKKTEEGYKKIGTLFGAMTPEVKEASIRSYLGYVAIVNHQNRVHNYLQVMNRMVALNIVPAKLLCDQLMCSDKLVYKNPCFWIEAFRLIRKVIGGVDYKGVREIMKCCKEKALSFPANVSVNILPQLLELIELIEHIFNRNACLLPAYFIINEIKKTDYQNMHWRVSNLTANFIEEFVSVAQMLSIIGHSSMLPIVEHSSYADNLIIPWKLDPDTLKLSLRGNLPYDEELLQPQARLLRFVLQQPYSRDMVCSMLNFQKQQKQKCAALEEQLVWLVLNAMEYSEKEGTQAQNAAGATMNEHDTDQSHTQWVWLHLSSQLIYFVLFQFATFQNIVNALHEKLAVRNLRRGRDHLMWVFLQYISGSIQKHSILNFLPILKLYDILYPEKESLPVPDNSNPNCTHQMAPTCIWIHLMKRAQTENYNINRPIPIALRLHFEYLQHLAMPSNNPTLFMGSEYRFALLCNAYSTQTDYFSRPMQALIDTILGNSKNPQANMVGGGGVQPLPTAPLSMRVLDSLTIHSKMSLIHSIVMHMIKQAQNKSSIPNGNNMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSQAWGILYTLLEMFSYRMHHIHSHYRVQLLTHLHSLASVPHTNQMQLHSCVESTALRLIIGLGSVEVQAQLSRYLSEPKPPGNIVSAESEELNRALILTLARSMHITGTGNDPQSSAWCKDLLQNIMLSTPHAWPQHTLYCFPPVLNEFFMQHNIPKESKQLLKKTVDEEYRNWASMTNENDIIAHFGMTVNPPLFLCLVFKMIIETDVISPVAYKILERIGARALSTHLRKMCDYLLFEVANSGGGAHVNKCVDTINDMIWKYNIVTIDRLVLCLILRTLDGNEAQVSFYIIQLLLLKTSEFRNRVQEFITINSPEHWKQNNWHERHLAFHQKFPEKFAPDESVSHPTLPVYFGNVCLRFLPVLDIIVHRFLEVPTQLSKTLDVILDHLGSLYKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGTVVGSLKDVRPENWALTEAYQAYMMTKETDNVNWVPELSYYINLVRRMQDTMDGKNIFSGTDWRFNEFPNPPAHALYVTCVELLGLPVGPNVVANSIIDVLVKGYTVVPNAVIHNWANTIGLIMAALPEAYWSVIYERMQGALNSKAMKEWTYRQSPFEMFNFKIVKESMLDRSYVTVLAIVHSIFHHFGIGQLATVTESLKEKLKPLVHTEYQLIYVCHVVGPFLHRLSIERVRAVADITLMLYELLEQVDKAQPTQPIRYMDPICDLLYHIKYMFVGDTMKTELEAIIRRLRPALQMRLRFITRLNVEEIGVEQKASTAQGVANVATGVTATGTASGTTGTTQGVVTPGQVASGSAAGPQQQQTQVSGVANPNVALQQQLQQQMGQGIQSHH
Length1464
PositionTail
OrganismAnopheles minimus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.09
Grand average of hydropathy-0.070
Instability index43.98
Isoelectric point7.91
Molecular weight167210.17
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08186
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.74|      16|      17|    1400|    1415|       1
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 1390- 1405 (25.78/14.56)	TAQGVANVATGVTATG
 1406- 1421 (28.96/17.18)	TASGTTGTTQGVVTPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.28|      13|      17|     284|     299|       2
---------------------------------------------------------------------------
  284-  299 (17.42/18.83)	PYDEELLqpqARLLRF
  304-  316 (25.86/16.01)	PYSRDMV...CSMLNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.52|      14|      17|    1424|    1440|       3
---------------------------------------------------------------------------
 1424- 1437 (24.86/18.31)	ASGSAAGPQQQQTQ
 1442- 1455 (24.66/ 9.28)	ANPNVALQQQLQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.29|      60|     150|      44|     130|       4
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   44-  109 (92.11/68.80)	FQEDKNIVPSFDEEEQRKKTEegYKKIGTLFGAMTPE.....VKEASIRSYLGY...VAIVNHQnrvhNYLQVM
  197-  264 (93.17/52.92)	FNRNACLLPAYFIINEIKKTD..YQNMHWRVSNLTANfieefVSVAQMLSIIGHssmLPIVEHS....SYADNL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     186.70|      50|      52|     434|     485|       5
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  341-  374 (29.45/11.08)	.........YSEKEGTQAQNAAgatmNEHDTDQSHTQWVWLHL............
  385-  429 (64.78/30.68)	QFATFQNIVNALHEKLAVR.NL....RRGRDHLM.....WVFLQYiSGSIQKHSI
  434-  483 (92.46/53.38)	PILKLYDILYPEKESLPVPDNS....NPNCTHQMAPTCIWIHLMK.RAQTENYNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.76|       9|      15|     756|     766|       6
---------------------------------------------------------------------------
  756-  766 (14.39/12.41)	PQssAWCKDLL
  774-  782 (20.36/10.59)	PH..AWPQHTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     210.34|      57|     320|     990|    1047|       7
---------------------------------------------------------------------------
  991- 1047 (98.56/70.05)	PTLPVYFGNVCLRFLPV.........LDIIVH.RFLEVPTQL....SKTLDVILDHLGSLYKFHDRPITYL
 1142- 1201 (56.05/31.78)	PAHALYVTCVELLGLPVgpnvvansiIDVLVK.GYTVVPNAVihnwANTIGLIMAALPEAY..........
 1335- 1377 (55.73/34.63)	...............PI.........CDLLYHiKYMFVGDTM....KTELEAIIRRLRPALQMRLRFITRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.19|      24|     318|     500|     559|       8
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  500-  533 (34.82/73.52)	HLAMpSNNPTLFmgseyrfalLCNAYS..TQTDYFS
  829-  854 (41.37/11.27)	HFGM.TVNPPLF.........LCLVFKmiIETDVIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.53|      14|      15|    1213|    1226|       9
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 1213- 1226 (25.61/20.97)	LNSKAMKEWTYRQS
 1231- 1244 (23.91/18.99)	FNFKIVKESMLDRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.28|      10|      17|    1083|    1094|      11
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 1083- 1094 (15.59/14.74)	NWALTEAYqaYM
 1103- 1112 (20.68/11.87)	NWVPELSY..YI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.73|      46|     612|     641|     718|      15
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  576-  621 (78.95/56.16)	LTIHS.KMSLIHS.IVMHMIKQAQNKSSIPNGNNMA.PALVETYS.RLLV
  654-  703 (64.78/66.54)	LEMFSyRMHHIHShYRVQLLTHLHSLASVPHTNQMQlHSCVESTAlRLII
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08186 with Med23 domain of Kingdom Metazoa
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