<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08186

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSAELRIVKLFEEVLVGMAMIAGFSFALLWLMLRNPVLTSICTFQEDKNIVPSFDEEEQRKKTEEGYKKIGTLFGAMTPEVKEASIRSYLGYVAIVNHQNRVHNYLQVMNRMVALNIVPAKLLCDQLMCSDKLVYKNPCFWIEAFRLIRKVIGGVDYKGVREIMKCCKEKALSFPANVSVNILPQLLELIELIEHIFNRNACLLPAYFIINEIKKTDYQNMHWRVSNLTANFIEEFVSVAQMLSIIGHSSMLPIVEHSSYADNLIIPWKLDPDTLKLSLRGNLPYDEELLQPQARLLRFVLQQPYSRDMVCSMLNFQKQQKQKCAALEEQLVWLVLNAMEYSEKEGTQAQNAAGATMNEHDTDQSHTQWVWLHLSSQLIYFVLFQFATFQNIVNALHEKLAVRNLRRGRDHLMWVFLQYISGSIQKHSILNFLPILKLYDILYPEKESLPVPDNSNPNCTHQMAPTCIWIHLMKRAQTENYNINRPIPIALRLHFEYLQHLAMPSNNPTLFMGSEYRFALLCNAYSTQTDYFSRPMQALIDTILGNSKNPQANMVGGGGVQPLPTAPLSMRVLDSLTIHSKMSLIHSIVMHMIKQAQNKSSIPNGNNMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSQAWGILYTLLEMFSYRMHHIHSHYRVQLLTHLHSLASVPHTNQMQLHSCVESTALRLIIGLGSVEVQAQLSRYLSEPKPPGNIVSAESEELNRALILTLARSMHITGTGNDPQSSAWCKDLLQNIMLSTPHAWPQHTLYCFPPVLNEFFMQHNIPKESKQLLKKTVDEEYRNWASMTNENDIIAHFGMTVNPPLFLCLVFKMIIETDVISPVAYKILERIGARALSTHLRKMCDYLLFEVANSGGGAHVNKCVDTINDMIWKYNIVTIDRLVLCLILRTLDGNEAQVSFYIIQLLLLKTSEFRNRVQEFITINSPEHWKQNNWHERHLAFHQKFPEKFAPDESVSHPTLPVYFGNVCLRFLPVLDIIVHRFLEVPTQLSKTLDVILDHLGSLYKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGTVVGSLKDVRPENWALTEAYQAYMMTKETDNVNWVPELSYYINLVRRMQDTMDGKNIFSGTDWRFNEFPNPPAHALYVTCVELLGLPVGPNVVANSIIDVLVKGYTVVPNAVIHNWANTIGLIMAALPEAYWSVIYERMQGALNSKAMKEWTYRQSPFEMFNFKIVKESMLDRSYVTVLAIVHSIFHHFGIGQLATVTESLKEKLKPLVHTEYQLIYVCHVVGPFLHRLSIERVRAVADITLMLYELLEQVDKAQPTQPIRYMDPICDLLYHIKYMFVGDTMKTELEAIIRRLRPALQMRLRFITRLNVEEIGVEQKASTAQGVANVATGVTATGTASGTTGTTQGVVTPGQVASGSAAGPQQQQTQVSGVANPNVALQQQLQQQMGQGIQSHH
Length1464
PositionTail
OrganismAnopheles minimus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.09
Grand average of hydropathy-0.070
Instability index43.98
Isoelectric point7.91
Molecular weight167210.17
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08186
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.74|      16|      17|    1400|    1415|       1
---------------------------------------------------------------------------
 1390- 1405 (25.78/14.56)	TAQGVANVATGVTATG
 1406- 1421 (28.96/17.18)	TASGTTGTTQGVVTPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.28|      13|      17|     284|     299|       2
---------------------------------------------------------------------------
  284-  299 (17.42/18.83)	PYDEELLqpqARLLRF
  304-  316 (25.86/16.01)	PYSRDMV...CSMLNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.52|      14|      17|    1424|    1440|       3
---------------------------------------------------------------------------
 1424- 1437 (24.86/18.31)	ASGSAAGPQQQQTQ
 1442- 1455 (24.66/ 9.28)	ANPNVALQQQLQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.29|      60|     150|      44|     130|       4
---------------------------------------------------------------------------
   44-  109 (92.11/68.80)	FQEDKNIVPSFDEEEQRKKTEegYKKIGTLFGAMTPE.....VKEASIRSYLGY...VAIVNHQnrvhNYLQVM
  197-  264 (93.17/52.92)	FNRNACLLPAYFIINEIKKTD..YQNMHWRVSNLTANfieefVSVAQMLSIIGHssmLPIVEHS....SYADNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     186.70|      50|      52|     434|     485|       5
---------------------------------------------------------------------------
  341-  374 (29.45/11.08)	.........YSEKEGTQAQNAAgatmNEHDTDQSHTQWVWLHL............
  385-  429 (64.78/30.68)	QFATFQNIVNALHEKLAVR.NL....RRGRDHLM.....WVFLQYiSGSIQKHSI
  434-  483 (92.46/53.38)	PILKLYDILYPEKESLPVPDNS....NPNCTHQMAPTCIWIHLMK.RAQTENYNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.76|       9|      15|     756|     766|       6
---------------------------------------------------------------------------
  756-  766 (14.39/12.41)	PQssAWCKDLL
  774-  782 (20.36/10.59)	PH..AWPQHTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     210.34|      57|     320|     990|    1047|       7
---------------------------------------------------------------------------
  991- 1047 (98.56/70.05)	PTLPVYFGNVCLRFLPV.........LDIIVH.RFLEVPTQL....SKTLDVILDHLGSLYKFHDRPITYL
 1142- 1201 (56.05/31.78)	PAHALYVTCVELLGLPVgpnvvansiIDVLVK.GYTVVPNAVihnwANTIGLIMAALPEAY..........
 1335- 1377 (55.73/34.63)	...............PI.........CDLLYHiKYMFVGDTM....KTELEAIIRRLRPALQMRLRFITRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.19|      24|     318|     500|     559|       8
---------------------------------------------------------------------------
  500-  533 (34.82/73.52)	HLAMpSNNPTLFmgseyrfalLCNAYS..TQTDYFS
  829-  854 (41.37/11.27)	HFGM.TVNPPLF.........LCLVFKmiIETDVIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.53|      14|      15|    1213|    1226|       9
---------------------------------------------------------------------------
 1213- 1226 (25.61/20.97)	LNSKAMKEWTYRQS
 1231- 1244 (23.91/18.99)	FNFKIVKESMLDRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.28|      10|      17|    1083|    1094|      11
---------------------------------------------------------------------------
 1083- 1094 (15.59/14.74)	NWALTEAYqaYM
 1103- 1112 (20.68/11.87)	NWVPELSY..YI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.73|      46|     612|     641|     718|      15
---------------------------------------------------------------------------
  576-  621 (78.95/56.16)	LTIHS.KMSLIHS.IVMHMIKQAQNKSSIPNGNNMA.PALVETYS.RLLV
  654-  703 (64.78/66.54)	LEMFSyRMHHIHShYRVQLLTHLHSLASVPHTNQMQlHSCVESTAlRLII
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08186 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TGVTATGTASGTTGTTQGVVTPGQVASGSAAGPQQQQTQVSGVANP
1399
1444










Molecular Recognition Features






MoRF SequenceStartStop




NANANA