<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08184

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSSGTATVSGGSLPALLMANGSSVGGGGGVGAGKGIGKPDMKPSGSGTSAGGTTGKVLLGGDKHETWQMELLMERLRTKAKSAQYKTFPEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPADGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAETKIKVNAFVALQALETDLHTLYTVSMQHYPDVHSQLLKAPLGVVQKRRGGHPMRLTYFVAPYELLDVGTRTINTLSSELIAKERIGCSVAVVLEASSANKLQIQPLLVVKAGSGGAATASQPVYTPIEKHNSTSLPATFVLRLSKPMPINGAVMRAIKATVGGSGANEQQGGEGTGTSGGSGLPSSLLGLIAHHASGGSVTDLVKGLLVSLPDQYHCYYLTDNPLLRGVMVSSIPFTEPQHVPKILTYLRQQAIFNQLLSSCIRTNASAAGGGRPSALQLLLDGGTHTIENGSNGGLLVFEVSALSCQNITVSLIHPYEESLATVEFDLQNIASISVRIYCSEGETSDEHTVERLSAVLQRCMSIPVTLRALMKHWEEEHEQKFKPNVLGSSTVASSGGGGGGGGGGPGGAGTGLNSSGDGTGTGGGVAGSGEDGSMNGFNLSSLGGPPTAVDGAGGGGGGSAATNGTSAPQTTSQRGLMNGEGNGLAASGNLGLDFCDMLTERNGNGLGGRVAGALGAREPPEPLAGGAAKKRRMEDFCKSPKSDSNLSVVGGGTDGSGVEKVNETGAINTTVTSQDVATAAAAAATSSGTTGNGEQRMQAGGATEEDTGGLPLFGETVPASGTEAKGSSLGGTTITNTIASAKNEPPSVLPADDDTAIVGAGVKMPLQSSSSSSLSSLSSSGFSLTGAPPGEPGTERPCPGTLLLESLECSGLEPDPMKRSTGPSTKRRRSSSSSSSSSSSSSSSSSSSSTTSGASEEVEESVDLVEAEMNSFFAEVNNTQPAATGAPKAMFGSTSGKPALGTVSPISGKLVSPSGGAGIDKPITTIGSSGLEIIPIPAGNTNITANAFPSTPVSSTPVTVPQIMANSGASSTSLTTTSTATKKSSSSSSSSSSSSSSSHRKSSDSTERSSSSNKDKKKKRKVDDSGHLAMGPPNKLPFKSGESSPHRSGIGSSSASGNKSSPKHSSPVHHSSPKHTGSSSGLGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGTKSSETSSGGGGGGGGGGSGIGISTTGGSSKERDKERSEKKTLQFSTTNAATGSALSANSGTSSSGSSSGGRSKNSGLKLKQLDLAAGSSLTISMGDSGSSSPVAPMIDLTGPGTVQGSALGSLGLAGAGLTTASSMLQALQAAKNRKPPSSAGGSGLGGSLSAVIDKLKSAQSADDEAVLVLPEMTITQQTTSSSMTAGTGIGAGVNIGGLGSISGGGGALKDPSKVGSSLLSATGSSSLANCVSSTTGIGAALTQSSSMTSAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSSKSSSNSSSGGSKSGGGSNKSGLKSGVSSGPVSSKQQQQNHTTSFSGAFPSSTKTPHYTSSSSSKTPFQKSNSFGSLGGGVGSGGTGMKTSKVSSPKSSSNPASSSSSSYSSKEKGGPASGRSKSSSASSLTGAALLSGGASGGGGGSGSSSLVNPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNNNSTAGGTSHSESNEAAKSLKDAAVRKQKAQLPITSSPQSVGSSPLRTFSTSPSGDASARLLSDLLGAAAKGGSKMSTSGTGSAGTAGGDGGTALHPLLPNIVQKMFGSDGSLQSKSNSSDGSMFPSAGRASPGMLSGSASRDGFRSGAGSAPGTPTTTGSMVLPPFPSPVSGGASNDGDPTGTLMRPPSRPSSTISNHSHSSQDGIVGGSGDTIPPAVTSMASMMMMSAMSAAGGGQSPASGSLSLDSASTQQLIAALAAKSGVASGGGGGSGVLPPPNSLLNNHTHLHHHGNHLNNHVVGGTAAALNNLPSPASVSVHIVKSPAPSPLPFTSPHSNASSTHGGSGTGGLDDDLMDEALIGIGSK
Length2111
PositionMiddle
OrganismAnopheles minimus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.297
Instability index52.05
Isoelectric point9.03
Molecular weight209510.82
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08184
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|    1326.87|     153|     154|     905|    1057|       1
---------------------------------------------------------------------------
  567-  732 (133.34/20.15)	GETSDEHTVERlsavlqRCmsiPVTLraLMKHWEeehEQKFKPNVLGSSTVASS........G....GGGGGGGGGPGGAGTGLNSS.G.....DGTGTGGG..VAG.........SGE..DGSMNGFnLSSLGGP......PTAVDG.AG.GGGG.......GSaaTNGTS...AP.QTTSQR...GlmngeG.NGLAAS..GN............................L.G..LDfcDMLTERNGNGL..............................
  735-  911 (105.30/14.12)	.RVAGALGARE......P........................PEPL...AGGAA........K....KRRMEDFCKSPKSDSNLSVV.G.....GGTDGSGVEKVNEtgainttvtSQDV......AT.AAAAAAT......SSGTTG.NG.EQRMqaggateED..TGGLP...LF.GETVPA...S.....G.TEAKGSslGGttitntiasakneppsvlpadddtaivgA.G..VK..MPLQSSSSSSL..............sslsSSGF.....SLT
  912- 1070 (240.22/43.14)	GAPPGEPGTER......PC...PGTL..LLESLE...CSGLEPDPMKRSTGPST........K....RRRSSSSSSSSSSSSSSSSS.S.....SSTTSGASEEVEE.........SVDLVEAEMNSF.FAEVNNT......QPAATG.AP.KAMF.......GS..TSGKP...AL.GTVSPI...S.....G.KLVSPS..GG............................A.G..ID..KPITTIGSSGL............eiipipAGNT.....NIT
 1072- 1233 (148.23/23.35)	NAFPSTPVSST......PV...TVPQ..IMAN......SGASSTSLT.TTSTAT........K....KSSSSSSSSSSSSSSSHRKS.S.....DSTERSSSSNKDK.........KKKR...........KVDDS......GHLAMG.PPnKLPF.......KS..GESSPhrsGI.GS.SSA...S.....G.NKSSPK..HS............................S.P..VHhsSPKHTGSSSGLgfhspkhgssvspkhplhSGGS.....STG
 1234- 1354 (125.16/18.39)	G...GKPSMS..................ALKSAA...ASG..SSPGTKS.....................SETSSGGGGGGGGGGSGiG.....ISTTGGSSK...E.........R.DKERSEKKTLqFSTTN..........AATGsAL.SANS.......GT..SSSGS...SS.GGRSKN...S.....GlKLKQLD..LA............................A.G..SS..LTI.SMGDSG......................S.....S..
 1355- 1502 (132.34/19.94)	..SPVAPMIDL......TG...PGTV..QGSALG...SLGLAGAGL...TTASSmlqalqaaK....NRKPPSSAGGSGLGGSLSAV.I.....DKLKSAQSAD.DE.........AV.LVLPEMTI........T......QQTTSS.SM.TAGT.......G............I.GAGVNI...G.....G..LGSIS..GG............................G.G..AL..KDPSKVGSSLL..............satgSSSLancvsSTT
 1505- 1637 (120.10/17.31)	GAALTQSSSMT......SA...PS....LTAAL....TSGKASEYMVKPSSDGI........KltiqNKKGSSKSSSNSSSGGSKSG.G.....GSNKSGLKSGVSS.........G......PVSSK.QQQQNHTtsfsgaFPSSTK.TP.HYTS.......SS..SSKTP...FQ.KSNSFG...S....lG.GGVG.S..GG............................T.................................................
 1741- 1880 (120.65/17.42)	...SARSNNNS......TA...GGTS..HSESNE...AAKSLKDAAVR....KQ........K....AQLPITSSPQSVGSSPLRTF.S.....TSPSGDASARLLS.........DLLGAAAKGGSK.MS.TSGT......GSAGTA.GG.D..........GG..TALHP...LLpNIVQKMfgsD.....G.SLQSKS..NS............................SdG..SM..FPSAGRASPGM..............................
 1882- 1979 (93.37/11.56)	......................................................................SGSASRDGFRSGAGSAP.G.....TPTTTGS..................MV...LPPF.PSPVSGG.......ASNDG.DP.TGTL.......MR..PPSRP...S..STISNH...S....hS.SQDGIV..GG............................S.GdtIP..PAVTSMASMMM..................MSAM.....SAA
 1980- 2092 (108.14/14.73)	G......GGQS......PA...SGSL..SLDS...................AST........Q....QLIAALAAKSGVASGGGGGS.GvlpppNSLLNNHTHLHHH.........GNHLNNHVVGGT.AAALNNL.......PSPAS.VS.VHIV.......KS..PAPSP....L.PFTSPH...S.....N.A.SSTH..GG............................S.G...............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.00|      61|    1667|       2|      80|       2
---------------------------------------------------------------------------
    2-   80 (93.35/58.48)	SSSGTATVSGGslPA...............LLMANGSSvGGGGGVGAGKGIGKPD.MKPSGSGTSAGGttgkvllggdkhetwQMELLMERLRTK
 1658- 1734 (96.65/35.24)	SSSYSSKEKGG..PAsgrsksssassltgaALLSGGAS.GGGGGSGSSSLVNPISiMKMLGYPTGSMG...............NMEGFAKSLDTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.90|      39|     215|     272|     316|       3
---------------------------------------------------------------------------
  272-  316 (62.71/67.24)	GGHPMRLTYfvapyeLLDVGTRTI.NTLSSELIAKE..RIGC.SVAVVL
  495-  537 (56.19/43.10)	GGRPSALQL......LLDGGTHTIeNGSNGGLLVFEvsALSCqNITVSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08184 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAKGGSKMSTSGTGSAGTAGGDGGTALHPLLPNIVQKMFGSDGSLQSKSNSSDGSMFPSAGRASPGMLSGSASRDGFRSGAGSAPGTPTTTGSMVLPPFPSPVSGGASNDGDPTGTLMRPPSRPSSTISNHSHSSQDGIVGGSGDTIPPAVTSMASMMMMSAMSAAGGGQSPASGSLSLDSASTQ
2) ASGGGGGSGVLPPPNSLLNNHTHLHHHGNHLNNHVVGGTAAALN
3) DTKFQIPKLSARSNNNSTAGGTSHSESNEAAKSLKDAAVRKQKAQLPITSSPQSVGSSPLRTFSTSPSG
4) GGVGAGKGIGKPDMKPSGSGTSAGGTTGKV
5) GLGGRVAGALGAREPPEPLAGGAAKKRRMEDFCKSPKSDSNLSVVGGGTDGSGVEKVNETGAINTTVTSQDVATAAAAAATSSGTTGNGEQRMQAGGATEEDTGGLPLFGETVPASGTEAKGSSLGGTTITNTIASAKNEPPSVLPADDDTAIVGAGVKMPLQSSSSSSLSSLSSSGFSLTGAPPGEPGTERPCPGTLLLESLECSGLEPDPMKRSTGPSTKRRRSSSSSSSSSSSSSSSSSSSSTTSGASEEVEESVDLVEAEMNSFFAEVNNTQPAATGAPKAMFGSTSGKPALGTVSPISGKLVSPSGGAGIDKPITTIGSSGLEIIPIPAGNTNITANAFPSTPVSSTPVTVPQIMANSGASSTSLTTTSTATKKSSSSSSSSSSSSSSSHRKSSDSTERSSSSNKDKKKKRKVDDSGHLAMGPPNKLPFKSGESSPHRSGIGSSSASGNKSSPKHSSPVHHSSPKHTGSSSGLGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGTKSSETSSGGGGGGGGGGSGIGISTTGGSSKERDKERSEKKTLQFSTTNAATGSALSANSGTSSSGSSSGGRSKNSGLKLK
6) HWEEEHEQKFKPNVLGSSTVASSGGGGGGGGGGPGGAGTGLNSSGDGTGTGGGVAGSGEDGSMNGFNLSSLGGPPTAVDGAGGGGGGSAATNGTSAPQTTSQRGLMNGEGNG
7) KPSSDGIKLTIQNKKGSSKSSSNSSSGGSKSGGGSNKSGLKSGVSSGPVSSKQQQQNHTTSFSGAFPSSTKTPHYTSSSSSKTPFQKSNSFGSLGGGVGSGGTGMKTSKVSSPKSSSNPASSSSSSYSSKEKGGPASGRSKSSSASSLTGAALLSGGASGGGGGSGSSSL
8) SVSVHIVKSPAPSPLPFTSPHSNASSTHGGSGTGGLDDDLMDE
1813
2011
1732
29
731
598
1535
2061
1998
2054
1800
58
1334
709
1704
2103










Molecular Recognition Features






MoRF SequenceStartStop




1) LKLKQLDLA
2) LSDLL
3) SALKSAA
1331
1807
1240
1339
1811
1246