<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08184

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSSGTATVSGGSLPALLMANGSSVGGGGGVGAGKGIGKPDMKPSGSGTSAGGTTGKVLLGGDKHETWQMELLMERLRTKAKSAQYKTFPEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPADGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAETKIKVNAFVALQALETDLHTLYTVSMQHYPDVHSQLLKAPLGVVQKRRGGHPMRLTYFVAPYELLDVGTRTINTLSSELIAKERIGCSVAVVLEASSANKLQIQPLLVVKAGSGGAATASQPVYTPIEKHNSTSLPATFVLRLSKPMPINGAVMRAIKATVGGSGANEQQGGEGTGTSGGSGLPSSLLGLIAHHASGGSVTDLVKGLLVSLPDQYHCYYLTDNPLLRGVMVSSIPFTEPQHVPKILTYLRQQAIFNQLLSSCIRTNASAAGGGRPSALQLLLDGGTHTIENGSNGGLLVFEVSALSCQNITVSLIHPYEESLATVEFDLQNIASISVRIYCSEGETSDEHTVERLSAVLQRCMSIPVTLRALMKHWEEEHEQKFKPNVLGSSTVASSGGGGGGGGGGPGGAGTGLNSSGDGTGTGGGVAGSGEDGSMNGFNLSSLGGPPTAVDGAGGGGGGSAATNGTSAPQTTSQRGLMNGEGNGLAASGNLGLDFCDMLTERNGNGLGGRVAGALGAREPPEPLAGGAAKKRRMEDFCKSPKSDSNLSVVGGGTDGSGVEKVNETGAINTTVTSQDVATAAAAAATSSGTTGNGEQRMQAGGATEEDTGGLPLFGETVPASGTEAKGSSLGGTTITNTIASAKNEPPSVLPADDDTAIVGAGVKMPLQSSSSSSLSSLSSSGFSLTGAPPGEPGTERPCPGTLLLESLECSGLEPDPMKRSTGPSTKRRRSSSSSSSSSSSSSSSSSSSSTTSGASEEVEESVDLVEAEMNSFFAEVNNTQPAATGAPKAMFGSTSGKPALGTVSPISGKLVSPSGGAGIDKPITTIGSSGLEIIPIPAGNTNITANAFPSTPVSSTPVTVPQIMANSGASSTSLTTTSTATKKSSSSSSSSSSSSSSSHRKSSDSTERSSSSNKDKKKKRKVDDSGHLAMGPPNKLPFKSGESSPHRSGIGSSSASGNKSSPKHSSPVHHSSPKHTGSSSGLGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGTKSSETSSGGGGGGGGGGSGIGISTTGGSSKERDKERSEKKTLQFSTTNAATGSALSANSGTSSSGSSSGGRSKNSGLKLKQLDLAAGSSLTISMGDSGSSSPVAPMIDLTGPGTVQGSALGSLGLAGAGLTTASSMLQALQAAKNRKPPSSAGGSGLGGSLSAVIDKLKSAQSADDEAVLVLPEMTITQQTTSSSMTAGTGIGAGVNIGGLGSISGGGGALKDPSKVGSSLLSATGSSSLANCVSSTTGIGAALTQSSSMTSAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSSKSSSNSSSGGSKSGGGSNKSGLKSGVSSGPVSSKQQQQNHTTSFSGAFPSSTKTPHYTSSSSSKTPFQKSNSFGSLGGGVGSGGTGMKTSKVSSPKSSSNPASSSSSSYSSKEKGGPASGRSKSSSASSLTGAALLSGGASGGGGGSGSSSLVNPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNNNSTAGGTSHSESNEAAKSLKDAAVRKQKAQLPITSSPQSVGSSPLRTFSTSPSGDASARLLSDLLGAAAKGGSKMSTSGTGSAGTAGGDGGTALHPLLPNIVQKMFGSDGSLQSKSNSSDGSMFPSAGRASPGMLSGSASRDGFRSGAGSAPGTPTTTGSMVLPPFPSPVSGGASNDGDPTGTLMRPPSRPSSTISNHSHSSQDGIVGGSGDTIPPAVTSMASMMMMSAMSAAGGGQSPASGSLSLDSASTQQLIAALAAKSGVASGGGGGSGVLPPPNSLLNNHTHLHHHGNHLNNHVVGGTAAALNNLPSPASVSVHIVKSPAPSPLPFTSPHSNASSTHGGSGTGGLDDDLMDEALIGIGSK
Length2111
PositionMiddle
OrganismAnopheles minimus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.297
Instability index52.05
Isoelectric point9.03
Molecular weight209510.82
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08184
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|    1326.87|     153|     154|     905|    1057|       1
---------------------------------------------------------------------------
  567-  732 (133.34/20.15)	GETSDEHTVERlsavlqRCmsiPVTLraLMKHWEeehEQKFKPNVLGSSTVASS........G....GGGGGGGGGPGGAGTGLNSS.G.....DGTGTGGG..VAG.........SGE..DGSMNGFnLSSLGGP......PTAVDG.AG.GGGG.......GSaaTNGTS...AP.QTTSQR...GlmngeG.NGLAAS..GN............................L.G..LDfcDMLTERNGNGL..............................
  735-  911 (105.30/14.12)	.RVAGALGARE......P........................PEPL...AGGAA........K....KRRMEDFCKSPKSDSNLSVV.G.....GGTDGSGVEKVNEtgainttvtSQDV......AT.AAAAAAT......SSGTTG.NG.EQRMqaggateED..TGGLP...LF.GETVPA...S.....G.TEAKGSslGGttitntiasakneppsvlpadddtaivgA.G..VK..MPLQSSSSSSL..............sslsSSGF.....SLT
  912- 1070 (240.22/43.14)	GAPPGEPGTER......PC...PGTL..LLESLE...CSGLEPDPMKRSTGPST........K....RRRSSSSSSSSSSSSSSSSS.S.....SSTTSGASEEVEE.........SVDLVEAEMNSF.FAEVNNT......QPAATG.AP.KAMF.......GS..TSGKP...AL.GTVSPI...S.....G.KLVSPS..GG............................A.G..ID..KPITTIGSSGL............eiipipAGNT.....NIT
 1072- 1233 (148.23/23.35)	NAFPSTPVSST......PV...TVPQ..IMAN......SGASSTSLT.TTSTAT........K....KSSSSSSSSSSSSSSSHRKS.S.....DSTERSSSSNKDK.........KKKR...........KVDDS......GHLAMG.PPnKLPF.......KS..GESSPhrsGI.GS.SSA...S.....G.NKSSPK..HS............................S.P..VHhsSPKHTGSSSGLgfhspkhgssvspkhplhSGGS.....STG
 1234- 1354 (125.16/18.39)	G...GKPSMS..................ALKSAA...ASG..SSPGTKS.....................SETSSGGGGGGGGGGSGiG.....ISTTGGSSK...E.........R.DKERSEKKTLqFSTTN..........AATGsAL.SANS.......GT..SSSGS...SS.GGRSKN...S.....GlKLKQLD..LA............................A.G..SS..LTI.SMGDSG......................S.....S..
 1355- 1502 (132.34/19.94)	..SPVAPMIDL......TG...PGTV..QGSALG...SLGLAGAGL...TTASSmlqalqaaK....NRKPPSSAGGSGLGGSLSAV.I.....DKLKSAQSAD.DE.........AV.LVLPEMTI........T......QQTTSS.SM.TAGT.......G............I.GAGVNI...G.....G..LGSIS..GG............................G.G..AL..KDPSKVGSSLL..............satgSSSLancvsSTT
 1505- 1637 (120.10/17.31)	GAALTQSSSMT......SA...PS....LTAAL....TSGKASEYMVKPSSDGI........KltiqNKKGSSKSSSNSSSGGSKSG.G.....GSNKSGLKSGVSS.........G......PVSSK.QQQQNHTtsfsgaFPSSTK.TP.HYTS.......SS..SSKTP...FQ.KSNSFG...S....lG.GGVG.S..GG............................T.................................................
 1741- 1880 (120.65/17.42)	...SARSNNNS......TA...GGTS..HSESNE...AAKSLKDAAVR....KQ........K....AQLPITSSPQSVGSSPLRTF.S.....TSPSGDASARLLS.........DLLGAAAKGGSK.MS.TSGT......GSAGTA.GG.D..........GG..TALHP...LLpNIVQKMfgsD.....G.SLQSKS..NS............................SdG..SM..FPSAGRASPGM..............................
 1882- 1979 (93.37/11.56)	......................................................................SGSASRDGFRSGAGSAP.G.....TPTTTGS..................MV...LPPF.PSPVSGG.......ASNDG.DP.TGTL.......MR..PPSRP...S..STISNH...S....hS.SQDGIV..GG............................S.GdtIP..PAVTSMASMMM..................MSAM.....SAA
 1980- 2092 (108.14/14.73)	G......GGQS......PA...SGSL..SLDS...................AST........Q....QLIAALAAKSGVASGGGGGS.GvlpppNSLLNNHTHLHHH.........GNHLNNHVVGGT.AAALNNL.......PSPAS.VS.VHIV.......KS..PAPSP....L.PFTSPH...S.....N.A.SSTH..GG............................S.G...............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.00|      61|    1667|       2|      80|       2
---------------------------------------------------------------------------
    2-   80 (93.35/58.48)	SSSGTATVSGGslPA...............LLMANGSSvGGGGGVGAGKGIGKPD.MKPSGSGTSAGGttgkvllggdkhetwQMELLMERLRTK
 1658- 1734 (96.65/35.24)	SSSYSSKEKGG..PAsgrsksssassltgaALLSGGAS.GGGGGSGSSSLVNPISiMKMLGYPTGSMG...............NMEGFAKSLDTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.90|      39|     215|     272|     316|       3
---------------------------------------------------------------------------
  272-  316 (62.71/67.24)	GGHPMRLTYfvapyeLLDVGTRTI.NTLSSELIAKE..RIGC.SVAVVL
  495-  537 (56.19/43.10)	GGRPSALQL......LLDGGTHTIeNGSNGGLLVFEvsALSCqNITVSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08184 with Med1 domain of Kingdom Metazoa
Unable to open file!