<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08171

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMNPGRLGLAPLLQENPLWISWHDSNWIPVLNPGNVMDYFSEKSNPFYDRTCNNEIVRMQRQSLELLNNMTGVEYIPLHVQDPILYVIRKQHRHSPTEATPMADYYIIAGTVYQAPDLASVFNSRILSTVHHLQTAFDEASSYSRYHPSKGYSWDFSSNKASTHAMAEQVAEKTKTQTKKEAPVKEEPSSIFQRQRVDMLLGDLLRKFPLPLPQMTNNPTGGNPSDAGNASNNHGGAAGDSDHVGSDAILIKQEPTEAGVGRGGNNDVPPEKKMKL
Length275
PositionHead
OrganismAnopheles merus (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.08
Grand average of hydropathy-0.634
Instability index44.97
Isoelectric point6.20
Molecular weight30625.99
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08171
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.58|      12|      65|      10|      39|       1
---------------------------------------------------------------------------
    1-   18 (19.07/29.09)	MNPGRLglapllQENPLW
   30-   47 (17.52/ 7.71)	LNPGNVmdyfseKSNPFY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.35|      26|     162|      67|      98|       2
---------------------------------------------------------------------------
   67-   98 (39.05/38.19)	NNMTGVEYIPLHV.QDPILyvIRKQhrhsPTEA
  231-  257 (43.30/24.93)	NNHGGAAGDSDHVgSDAIL..IKQE....PTEA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08171 with Med6 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FPLPLPQMTNNPTGGNPSDAGNASNNHGGAAGDSDHVGSDAILIKQEPTEAGVGRGGNNDVPPEKKMKL
2) THAMAEQVAEKTKTQTKKEAPVKEEPSSIFQ
207
162
275
192










Molecular Recognition Features






MoRF SequenceStartStop




1) HVGSDAILIKQEPTEAGVGR
2) PPEKKMKL
242
268
261
275