<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08170

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSADLRIVKLFEEVVEDKNIVPNFDEEEQRKKTEEGYKKIGTLFGAMAPESKEAAIRNYLGYVASVNHQNRVHNYLQVMNRMVALNIIPAKLLCDQLMCSEKLVYKNPCFWIEAFRLIRKVIGGVDYKGVREIMKCCKEKALSFPASVSVNILPQLLELVELIEHIFNRNACLLPAYFIINEIKKTDYQNMHWRVSNLTANFIEEFVSVAQMLSIIGHSAMLPIVEHSSYADNLIIPWKLDPDTLKLSLRGNLPYDEELLQPQARLLRFVLQQPYSRDMVCSMLNFQKQQKQKCAALEEQLVWLVLNAMECSEKEAAQGGQGAAGGTGMNEHEGDQSHTQWIWLHLSSQLIYFVLFQFATFQNIVNTLHEKLAVRNLRRGRDHLMWVFLQYISGSIQKHSILNFLPILKLYDILYPEKEPLPVPDNNNPNCTHQMAPTCIWIHLMKRAQTENYNINRPVPIALRLHFEYLQHLAMPSNNPTLFMGSEYRFALLCNAYSTQTDYFSRPMQALIDTILGNSKNPQANMVGGGQPLPTAPLSMRVLDSLTIHSKMSLIHSIVMHMIKQAQNKSSIPNGNNMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSQAWGILYTLLEMFSYRMHHIHSHYRVQLLTHLHSLASVPHTNQMQLHSCVESTALRLIIGLGSVEVQAQLSRYVSEPKPPGNIVSGESEELNRALILTLARSMHITGTGNDPQSSAWCKDLLQNIMVNTPHAWPQHTLYCFPPVLNEFFMQHNIPKESKQLLKKTVDEEYRNWASMTNENDIIAHFGMTVNPPLFLCLVFKMIIETDGISPVAYKILERIGARALSTHLRKMCDYLLFEVANSGGGAHVNKCVDTINDMIWKYNIITIDRLVLCLILRTLDGNEAQVSFYIIQLLLLKTTEFRNRVQEFITINSPEHWKQNNWHERHLAFHQKFPEKFAPDESVSHPSLPVYFGNVCLRFLPVLDIIVHRYLEVPTQLSKTLDVILDHLGSLYKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGTVVGSLKDVRPENWALTEAYQAYMMTKESDNVNWVPELSYYINLVRRMQDTMDGKNIFAGTDWRFNEFPNPPAHALYVTCVELLGLPVGPSVVANSIIDVLVKGYPVVPNGVIHNWANTIGLIMAALPEAYWSVIYERMQEALSSKAMKEWTYRQSPFDMFNFKIVKEAMLDRSYVTVLAIVHSIFHHFGIGQLATITDSIKEKLKPLVHTEYQLIYLCHVVGPFLHRLSIERARAVADITLMLYELLEQVDKAQPAQPLRYMDPICDLLYHIKYMFVGDTMKTELEAIIRRLRPALQMRLRFITRLNVEEIGVDQNAAGGGGGGAGGAATATGQGVAGAGPGVGPAPSGVVAGAPGATQGVVASGQAAPGTAAGPQQPQQVVGVVGNQNVALQQQLQQQQMGQGIQSHH
Length1450
PositionTail
OrganismAnopheles merus (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.09
Grand average of hydropathy-0.098
Instability index45.72
Isoelectric point7.47
Molecular weight164354.49
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08170
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1195.95|     318|     327|     666|     992|       1
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  410-  732 (353.43/225.10)	...LYDILY..PE...KE.P......LPvPDNNNP.NCTHQMAPTCiwIHLMKRAQT...ENYNiNRpvpIALRLHFEYLQHLAMpSNNPTLFmgseyrfalLCNAYS..TQTDYFSR..PMQALIDTIL..GNSKNPQ............ANmVGGGQPLPtaplsmRVLDslTIHS.....KMS...LIHS...IVMHMIKQAQnkssipNGNNMAPALVETYSRLLVYTEIESlGIKGFLGQLLPQVFKSQAWgilytllemfsyrmHHIHSHYRVQLLTHLHSLAS......VPHTNqmqLH.......S.......CVE.....................STALRLIIG.LGSV.EVQAQLSRYVSEPKPPGNIVSGESEELNRALILTlarsmhITGTGNDPQSSAWC
  733- 1055 (518.11/330.03)	KDLLQNIMVNTPH...AW.PQHTLYcFP.PVLNEF.FMQHNIPKES..KQLLKKTVD...EEYR.NW...ASMTNENDIIAHFGM.TVNPPLF.........LCLVFKMIIETDGISP..VAYKILERIG..ARALSTHLRKMCdYLLFEVAN.SGGGAHVN......KCVD..TINDMiWKYNII...TIDR...LVLCLILRTL......DGNEAQVSFYIIQLLLLKTTEFRN.RVQEFITINSPEHWKQNNW..............HERHLAFHQKFPEKFAPDES......VSHPS...LPVY..FGNV.......CLRFL.PVLDIIVH.RYLEVPTQLSKTLDVILDhLGSLyKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGT......VVGSLKDVRPENWA
 1057- 1344 (324.41/194.26)	TEAYQAYMMTKESdnvNWvPELSYY......INLVrRMQDTM..DG..KNIFAGT.DwrfNEFP.NP...PAHALYVTCVELLGL.PVGPSVV.........ANSIIDVLVKGYPVVPngVIHNWANTIGliMAALPEAYWSVI.YERMQEAL.SSKAMKEW......TYRQ..SPFDM.FNFKIVkeaMLDRsyvTVLAIVHSIF......H......HFGIGQLATI.TDSIKE.KLKPLV......H....................TEYQLIYLCHVVGPFLHRLSieraraVADIT...LMLYelLEQVdkaqpaqPLRYMdPICDLLYHiKYMFVGDTMKTELEAIIR.RLRP.ALQMRL.RFI............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.06|      14|      44|     330|     344|       2
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  330-  344 (24.75/20.51)	NEHEGdQSHTQWIWL
  376-  389 (27.31/17.00)	NLRRG.RDHLMWVFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.15|      19|      20|    1376|    1394|       4
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 1353- 1371 (20.76/ 8.92)	GVDqnaagGGGGGA...GGA.....AT
 1376- 1394 (37.32/21.98)	GVA.....GAGPGV...GPAPSGVVAG
 1396- 1415 (22.07/ 9.96)	..P.....GATQGVvasGQAAPGTAAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.96|      15|      15|      45|      59|       6
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   45-   59 (25.54/16.42)	GAMAPESKEAAIRNY
   61-   75 (27.41/18.19)	GYVASVNHQNRVHNY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08170 with Med23 domain of Kingdom Metazoa
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