<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08165

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPQPLEQGGAVTSFIPTGQEMAQRQNLIPLGRLIDFIIQRTYHELTVLAELLPRKTDMDRKIEIYNFSASTRQLFIRLLALVKWANSASKVDKSAKIMGFLDKQSMLFIDTADMLSRVARETLVHARLPNFHIPAAVEILTTGSYSRLPSVIRDRIVPPDPITPAEKRQTLQRLNQVIQHRLVTGSLLPQLRKFRIENGRVTFKVDHEFEVSLTVMGDAPTVPWRLLDIDFLVEDKETGDGKALVHPLQVNYIHQLIQGRIVDCTDALAEVYTCLHYFCQSLQLEVLYTQTLRLIRDRLDDHIHVDEYVVGSRLTVSYWRELTNKDPKSELGYRLTIQTDPNDAAKQLAILHVPSIGNKEADIADRAVRSDLLSMERLLVHTVYVRSLARLNDVKTELQLFLKDVEYNIQGTPAMLTVPVLNPCLRAEHIYITVDTHTGMLRCHVPKHLDCPIMPEMQHALNNDWSKLQHLISELRYWITQRRCEKTLQHLPAATQDRLPLIYSHTHPIARMGPHKVFIQLYRHANVILIVELKEKKTCPNEMTYTFYLVLVKPSSVEEGQSPDVLSGQPAQPSAAGGPAPGSDAANAAMPKMYLRVLSMIEFDTFVATHGPGTYIDDPSPTSTSGTSVKRKVSPLDNALSAIGPPLKQQKTIYPAYFIPELAHVVAMCDEKLPFVTLAKEFSMRKIPHGGLQVEANATSLVLKLLTLPQPKPPQAPPTPQQQQQQQQQQQQQPGTSDAKSSGAGASANEPKTVHVPSIDKQVWNALLKRLLSVSVRAQVNKSNQTRLWTMELVFYGSPLPSLHHKEQGMRRAVYLQYEMQPVESVSKVVDQLLSDWSKIVYLYTLVHEFREQYNNEKYNLASMVAIKSYSYTNLLLAYGPNKDVSVNICWDTEAKEFRLVFTGGNSAINAHSMMRDQLQAHLNHNYSLAQVVHMLHETYQPLSSIAKLPIIPHLAILQSPKIPVLSFCIIPQSPTLLRISFQGVYCLEVRFRGGGLCTIRDGAYSRFDRSHVVEEFTPTQGLKGFLSKYVDETAVFRRRSQSEDDNPPSPVTLEDPSAGAGNNGGGGGGGGGAGGGANTFLSGGTGMRGPQSPRDPGLRFAAPLTPPTSSNPHTPASPHPIGGGGGAGGAGGAGGQGGQGGQQQGHMNNFNMTSPPASHMPHPSPGGGLMPSSPLNAQPSPMAAHSPGPSSLSYMQSHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTSHHYTSRVLPARSWAGAIPTTLTYEALDTLCRATPHPQKEVPGPELSPLERFLGSVFMRRQLQRIIHQEESLMAITSNEPGVVVFKADCLQYQVFLNPNHMQSLHLKVDQLPMGPMMDGKPPYQWAAQDLQILEQFFDHRVAAPPYRPAVMTSFTRMLNLPAKVLKDFIQIMRLDLMPELVQGNKWNVQFVLRVPPSATPIVPVGTTTILSHRQKILFFIQITRVPYLPNMEWKDAVTMLLPMVYDMNMNHTTLAERREPMPPQLTSAVSAHLRRFSECSVLLPDECSLFPAVHDLLLTLTLPNEPPAPGQMQMQQLGGVMQPGGGPGVPGGPGGPMGGQIGGPTPQVVPQVGSSPSPMMHSPMQQMGGGGPQPGAYGGMVGGPGGGPQSGGPVGGGPGGPN
Length1641
PositionTail
OrganismAnopheles merus (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.07
Grand average of hydropathy-0.274
Instability index52.19
Isoelectric point8.55
Molecular weight180216.88
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08165
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     315.67|      50|      50|    1071|    1120|       1
---------------------------------------------------------------------------
 1071- 1101 (48.33/15.78)	........................................GGGGAGGGANTFLSGGT.....GMRGPQS....PRDPGLR
 1102- 1149 (76.17/29.35)	FAAPLT.PPT.....SSNPH.......TPASP.....hpiGGGGGAGGA.....GGA.....GGQGGQG....GQQQGHM
 1150- 1223 (53.21/18.16)	NNFNMTsPPA.....SHMPHpspggglMPSSPlnaqpspmAAHSPGPSSLSYMQSHTdgspfAALSPAA.snwPGSPGMP
 1542- 1582 (64.53/23.68)	...PNE.PPA.....PGQMQ.......MQQLG........GVMQPGGGP.G.VPGGP.....G..GPMG....GQIGG..
 1583- 1640 (73.43/28.02)	.PTPQV.VPQvgsspSPMMH..........SP....mqqmGGGGPQPGAYGGMVGGP.....G.GGPQSggpvGGGPGGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     170.25|      47|      65|    1394|    1441|       2
---------------------------------------------------------------------------
 1340- 1390 (52.09/32.31)	..MQSLHLKV.......DQLPMGP.MMDGKppyQWAAQdlqileqfFDHRVaaPPYRPAVM
 1391- 1441 (78.03/58.02)	TRMLNLPAKVLKdFIQIMRLDLMPELVQGN...KWNVQ........FVLRV..PPSATPIV
 1446- 1472 (40.13/22.81)	TTILSHRQKILF.FIQITRVPYLPNM.......EW..........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.48|      18|      19|     202|     219|       3
---------------------------------------------------------------------------
  202-  219 (31.13/21.89)	VTFK.VDHEFEVSLTVMGD
  223-  241 (28.35/19.24)	VPWRlLDIDFLVEDKETGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.32|      21|     314|     163|     183|       4
---------------------------------------------------------------------------
  163-  183 (36.81/21.95)	ITPAEKRQTLQRLNQVIQHRL
  480-  500 (37.51/22.51)	ITQRRCEKTLQHLPAATQDRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.90|      25|     322|     722|     746|       5
---------------------------------------------------------------------------
  722-  746 (43.96/23.54)	QQQQQQQQQQQQQPGTSDAKSSGAG
 1039- 1063 (43.94/23.53)	RRRSQSEDDNPPSPVTLEDPSAGAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.47|      20|      65|     857|     876|       6
---------------------------------------------------------------------------
  857-  876 (34.22/21.47)	NEKYNLASMVAIKSYSYTNL
  925-  944 (37.26/24.02)	NHNYSLAQVVHMLHETYQPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.64|      21|      22|      10|      30|      20
---------------------------------------------------------------------------
   10-   30 (37.43/24.61)	GAVTSFI..PTGQEMAQRQNLIP
   32-   54 (31.20/19.17)	GRLIDFIiqRTYHELTVLAELLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.92|      47|     559|     661|     721|      22
---------------------------------------------------------------------------
  647-  718 (55.63/42.89)	PLKqqktiypayfiPElaHVVAMCDEKLPFVTLAKEFSmRKIPhGGLQVEAnatslvlkllTL..PQPKPPQAP
 1225- 1280 (71.29/39.11)	PSP......rpgqsPE..HKVQTSHHYTSRVLPARSWA.GAIP.TTLTYEA........ldTLcrATPHPQKEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.83|      11|     369|     462|     472|      23
---------------------------------------------------------------------------
  462-  472 (22.04/14.31)	LNNDWSKLQHL
  834-  844 (20.79/13.07)	LLSDWSKIVYL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08165 with Med14 domain of Kingdom Metazoa
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