<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08161

Description Uncharacterized protein
SequenceMAIECPVCTLYLRSGMTLAEHLDTHPKENVIKALVSMVKPDSLPPFGSEPVEEPGTASEPVPAEGGSTAALHGQPGPSTSSSNAISFRPNERTSASVGIFEAQPSLFLDNALIATSATSSSSSSSSSSSTTTPATVQVNLTSSQAPQVTVVKKIDVHGVPCFQVNNVTLVKRELVQPVAAAAPAPPPPPPPPPPALPAPSVATVGTVPNELAAIGPLGDEYTEPSGSGTATGGSSSRVVYPRYTNELYSGPPPPYSRAISSTVASSTQITPVQQQQQQQQQTLQLSITKSSVGGLGVVGQQIQLLAKNLSEASVSAFKQYPASAVQTVSVLDRGSHEEPAVATASVASPSAPVGTPKLLYSVATTAGPRTAGTAITSTTTTTTTTTTTANTQSANTALVDHLAAGVPAITTTTTTTSGTKTTVSASPSSSKSNVVKVLSNVKVHTDLKDFQDIIMHLNAGQMSIVGDKTSLIPPVTERRPSAFAASTPGRSLLAITPAKSELPAEQQQQQQQPLCNAGMPTTKSEIEDLTGDYDHEVEYSGSWQEMDDHYADGEVRGQQWEGEEEEGAGGSGKRFRSASEQRDTLPAATASLDERMAPGEVAPGGGAACSSGSAMVTSVIRKTPQPVPCALSPPAPQQESKANVKRLVFRVAGNSATPTTVTISPAGPSSAPKIVRAWQGIKVEEDGTEPASSNADGIGGVAEPERAANDASAINTAAAVPAPTATVSTSLDYGAIKQRRGGFRPPKKLAIKPKRSSAGEGPAPSTSGKQGAPMQVDVVEPAQPPAPTTMVMATALTTLADVVCTTAAAAQHLTAEPFCSSSFNGITAVIQKTEATAATAGPYATEQQQQQQQPSSSAGDGVADAYHHHHHQPPDPVIKQEYSQPHAMPAPSASAAAGTLASNSSVYGVRSSYGLVPTSTGTASATSSSAPGGVRLMPQHRPSTEIDVGAYNISYVGEAGETIYHPLPKRDGKTFGAQELLPAGGNGLAAGGESGADGSTAAPAHPDSRRMEVEEVEEDEEEELGEEQMELEEDDEDAPELEEEEEDEEDEEEEEDEDDEDDEEEEEEKELEEDLIDDEEKEAHVHGELGQEGEEEEEAQLGSDEEEEEDDDEEEEEEEEDEEEEEEDEYDDDDVYEVEPRPVAGRYEPTRVDASSQPEAHVRRRLLMVVSKPATATVTASEAAEPNGPYERPLPVDPVAEVVASGSLVVKRLPAAAPGTPDDEKDLLEAGPSTRMLERSGIPRPKFRITNADPFRATAGLEPVRKTEVDAEPEYECSDSKDFLEQGSLGSNPAVSGTTVAAHEQIQTTGEPLVALKAAKAEPCHDGQDDGQDTSASSFLDLSTVRKGGLPPGPVTTDTSSSNSSSISNSNSSSSHSTTNISLSQHSHSQLSNRHSHSAVSGGCKEGGEGSGTSGGTRSLLSSGSSHASTSMERAPSTESLNIRTDEKMPAKGEISEQESNGDMDMTSWNHRQQHQQHGSADAPLDGGMMQASKIEPPMDVDSDSGDAMPKLPFADMMVARMHEPPGAYDEVGSSHHHHQQQQQTLHQPCETKYEETVGTTSYFGVATCSAVPVMQQPTDDPVRLNRPKPSGSGVARTYRCTLCAKVFSSIKQRRLHQQCEHVDDLVALSSSQQQQEMRVEEDNKPLMDGRQQQQLPQQQHQQQQQQQQAQQQQQQQMYKKAPIPVVMNYHWMKQEIERKSEAALRSSRLLMAGSSAGSSTSVVLPGTSSGEAAPGQQQLVLEQHVQVQVQVQTDGGTVAALSASAESALLPAAHCSVAARNRSYVCSTCSREFDRFNLFNEHLLEHPVECSACGRHFKQWRNFSLHIKRHLGIKEHQCRMCGKRFVIKQKLIEHMRVHTGHAPIKCKLCNRTFKRFSNLAQHRKRYHLNRTVVKEEYVCQLCGEVFHTMAKMEWHKETHEKKPKSCPYCREKFIHRNSLTRHIRLSHTDKYAKLENKTEPCSICQQPYTKTSMRRHLETHTKERMAYACGICNKRFTTNWNLKQHKWTHTNPTMKPFQCTYCPSAFVRESDFVTHVNAHRSIRPYTCNHCGSQFIRKYNWIRHTREHEIDKGHRCDVCGRQFHRKYYLTEHKRIHTGERPFACNICGKTSATKTNHNKHVRIHHARDPLTAEG
Length2134
PositionKinase
OrganismAnopheles merus (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.04
Grand average of hydropathy-0.669
Instability index60.99
Isoelectric point5.34
Molecular weight229920.38
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08161
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     169.90|      23|      25|    1015|    1037|       1
---------------------------------------------------------------------------
 1015- 1037 (44.63/27.52)	EVEEDEEEELGEEQMELEED...DED
 1043- 1059 (32.31/17.61)	EEEEDEEDE..EE....EED...EDD
 1060- 1080 (22.89/10.03)	...EDDEEE..EEEKELEEDlidDEE
 1092- 1113 (33.84/18.84)	EGEEEEEAQLGSDEEEEEDD...DE.
 1114- 1134 (36.23/20.77)	..EEEEEEEDEEEEEEDEYD...DDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     264.68|      27|      27|    1794|    1820|       2
---------------------------------------------------------------------------
 1794- 1820 (45.92/23.87)	FDRFNL.FNEHL..LEH......PVECSACGRHF..KQ
 1821- 1850 (27.75/11.56)	WRNFSLhIKRHLgiKEH........QCRMCGKRFviKQ
 1853- 1876 (36.02/17.16)	IEHMRV.HTGH.....A......PIKCKLCNRTF..KR
 1884- 1909 (34.24/15.96)	RKRYHL..NRTV..VKE......EYVCQLCGEVF..HT
 1910- 1934 (30.85/13.66)	MAKMEW.HKETH..EKK......PKSCPYCREKF....
 2000- 2027 (23.19/ 8.47)	..NWNL..KQHK..WTHtnptmkPFQCTYCPSAF....
 2029- 2057 (27.42/11.34)	..RESD.FVTHV..NAH..rsirPYTCNHCGSQF..IR
 2059- 2085 (39.29/19.38)	YNWIRH.TREHE..IDK......GHRCDVCGRQF..HR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.56|      54|      61|    1335|    1394|       3
---------------------------------------------------------------------------
 1335- 1389 (76.61/52.93)	....SASSfLDLSTVRKGGLPPGPVTTDTSSSNSSSISNSNSSSSHSTTNISLSQHsHS
 1394- 1432 (60.75/38.57)	R...HSHS..AVS....GGCKEGGEGSGTSGGTRSLLS...SGSSHAST..SM......
 1433- 1476 (64.20/32.17)	ErapSTES.LNIRTDEK..MPA...........KGEISEQESNGDMDMTSWNHRQQ.HQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     318.93|      59|      63|     671|     731|       4
---------------------------------------------------------------------------
  153-  216 (30.29/ 6.17)	...KIDVHGvpcfqvnnvtlvkrelvqpvaaaapAPPPPPPP...............................PPPALP.APS........VATVGT..........VPN..ELAAIGP...........
  554-  598 (45.46/12.95)	.....EVRG.........................QQWEGEEEEGAG............GSGK...........RFRSASEQR..........DT.............LPA..ATASLDERM...AP....
  599-  676 (49.91/17.66)	.G.EVAPGG.........................GAACSSGSAMVT............SVIRktpqpvpcalsPPAPQQESKAnvkrlvfrVAGNSA..........TPT...TVTISPAGpssAPKIVR
  679-  735 (71.52/24.61)	QGIKVEEDG.........................TEPASSNADGIG............GVAE...........PERAANDASA........INTAAA..........VPA..PTATVSTSLdygA.....
  736-  767 (32.75/ 7.28)	..IKQRRGG.........................FRPPKKLA..................IK...........PKR......S..........SAGE..........GPA..P....STS..........
  770-  813 (52.18/15.96)	QGAPMQVDV.........................VEPAQPPA...............................PTTMVM.ATA........LTTLAD..........VVC..TTAAAAQHL.........
  852-  935 (36.82/ 7.31)	..................................QQPSSSAGDGVAdayhhhhhqppdPVIK..qeysqphamPAPSASAA.A......gtLASNSSvygvrssyglVPTstGTASATSSS...APGGVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.19|      26|      27|    1480|    1506|       5
---------------------------------------------------------------------------
 1481- 1507 (44.18/27.31)	ADAPLD.GGMMQASKIEPPMDVDsDSGD
 1508- 1534 (46.00/24.37)	AMPKLPfADMMVARMHEPPGAYD.EVGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.12|      29|      29|     363|     391|       6
---------------------------------------------------------------------------
  339-  362 (27.42/12.32)	.......PAVATA.SVASPSAPV..GTPKLLYSV
  363-  391 (49.84/29.54)	ATTA..GPRTAGT.AITSTTTTT..TTTTTTANT
  394-  425 (24.85/10.35)	ANTAlvDHLAAGVpAITTTTTTTsgTKTTVSA..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.07|      21|      27|    1948|    1970|       7
---------------------------------------------------------------------------
 1961- 1981 (40.87/30.33)	PCSICQQ.PYTKTSMRRHLETH
 2103- 2124 (34.19/17.26)	ACNICGKtSATKTNHNKHVRIH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.63|      11|    1384|     268|     284|       8
---------------------------------------------------------------------------
  273-  283 (25.66/14.62)	QQQQQQQQQTL
 1658- 1668 (24.97/ 6.25)	QQQHQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.02|      27|      28|    1245|    1271|       9
---------------------------------------------------------------------------
 1245- 1271 (44.77/23.94)	PKFRITNADPF..RA..TAGLEP.VRKTEVDA
 1273- 1302 (33.87/16.17)	PEYECSDSKDFleQG..SLGSNPaVSGTTVAA
 1303- 1330 (32.38/15.11)	HEQIQTTGEPL..VAlkAAKAEP.CHDGQDD.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.30|      22|      28|    1143|    1166|      10
---------------------------------------------------------------------------
 1143- 1166 (33.72/20.01)	VAGRYEPTrvDASSQPEAHVRRRL
 1215- 1236 (33.58/14.59)	AAAPGTPD..DEKDLLEAGPSTRM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.40|      21|      28|     937|     960|      11
---------------------------------------------------------------------------
  937-  960 (34.04/26.35)	MPQHRPSTeidVGAYNISYVGEAG
  967-  987 (36.35/20.58)	LPKRDGKT...FGAQELLPAGGNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.49|      22|      28|    1727|    1748|      12
---------------------------------------------------------------------------
 1714- 1730 (19.68/ 7.90)	GSSAGSSTSVVL..............pGTSS
 1731- 1760 (28.72/15.68)	GEAAPGQQQLVLEQHVQV.qvqvqtdgGTVA
 1761- 1791 (26.09/13.41)	ALSASAESALLPAAHCSVaarnrsyvcSTCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.92|      22|      28|    1546|    1567|      18
---------------------------------------------------------------------------
 1546- 1567 (40.98/26.52)	LHQPCETKYEETVGTTSYFGVA
 1575- 1596 (38.94/24.76)	MQQPTDDPVRLNRPKPSGSGVA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08161 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAIGPLGDEYTEPSGSGTATGGSSSRVVYPRYTNEL
2) ATSSSSSSSSSSSTTTPATVQVNLTSSQAPQ
3) DSLPPFGSEPVEEPGTASEPVPAEGGSTAALHGQPGPSTSSSNAISFR
4) EATAATAGPYATEQQQQQQQPSSSAGDGVADAYHHHHHQPPDPVIKQEYSQPHAMPAPSASAAA
5) GEAGETIYHPLPKRDGKTFGAQELLPAGGNGLAAGGESGADGSTAAPAHPDSRRMEVEEVEEDEEEELGEEQMELEEDDEDAPELEEEEEDEEDEEEEEDEDDEDDEEEEEEKELEEDLIDDEEKEAHVHGELGQEGEEEEEAQLGSDEEEEEDDDEEEEEEEEDEEEEEEDEYDDDDVYEVEPRPVAGRYEPTRVDASSQPEAHVRRRLLMVVSKPATATVTASEAAEPNGPYERPLPVDPVAEVVASGSLVVKRLPAAAPGTPDDEKDLLEAGPSTRMLERSGIPRPKFRITNADPFRATAGLEPVRKTEVDAEPEYECSDSKDFLEQGSLGSNPAVSGTTVAAHEQIQTTGEPLVALKAAKAEPCHDGQDDGQDTSASSFLDLSTVRKGGLPPGPVTTDTSSSNSSSISNSNSSSSHSTTNISLSQHSHSQLSNRHSHSAVSGGCKEGGEGSGTSGGTRSLLSSGSSHASTSMERAPSTESLNIRTDEKMPAKGEISEQESNGDMDMTSWNHRQQHQQHGSADAPLDGGMMQASKIEPPMDVDSDSGDAMPKLPFADMMVARMHEPPGAYDEVGSSHHHHQQQQQTLHQPCETKY
6) GFRPPKKLAIKPKRSSAGEGPAPSTSGKQGAPMQVDVVEPAQPPAPTTMVMA
7) GPPPPYSRAISSTVASSTQITPVQQQQQQQQQTLQLS
8) HVDDLVALSSSQQQQEMRVEEDNKPLMDGRQQQQLPQQQHQQQQQQQQAQQQQQQQM
9) LVPTSTGTASATSSSAPGGVRLMPQHRPSTEIDVGAYNISY
10) NSATPTTVTISPAGPSSAPKIVRAWQGIKVEEDGTEPASSNADGIGGVAEPERAANDASAINTAAAVP
11) VGDKTSLIPPVTERRPSAFAASTPGRSLLAITPAKSELPAEQQQQQQQPLCNAGMPTTKSEIEDLTGDYDHEVEYSGSWQEMDDHYADGEVRGQQWEGEEEEGAGGSGKRFRSASEQRDTLPAATASLDERMAPGEVAPGGGAACSSGSAMVTSVIRKTPQPVPCALSPPAPQQESKANVKRLVFRV
12) VQPVAAAAPAPPPPPPPPPPALPAPSVATVG
212
117
41
834
957
742
250
1622
915
654
465
175
247
147
88
897
1554
793
286
1678
955
721
651
205










Molecular Recognition Features






MoRF SequenceStartStop




1) EAHVRRRLLMVVSK
2) KANVKRLVFRVA
3) KIVRAWQGIKVE
4) LDYGAIKQRRGGFRPPKKLAIKPKRSS
5) LVVKR
1159
641
673
731
1208
1172
652
684
757
1212